Menu
×
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Folly Beach Library
Closed for renovations
Phone: (843) 588-2001
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
Edgar Allan Poe/Sullivan's Island Library
9 a.m. - 6 p.m.
Phone: (843) 883-3914
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
McClellanville Library
Closed for renovations
Phone: (843) 887-3699
Edisto Library
9 a.m. - 6 p.m.
Phone: (843) 869-2355
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Baxter-Patrick James Island
9 p.m. - 8 p.m.
Phone: (843) 795-6679
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Folly Beach Library
Closed for renovations
Phone: (843) 588-2001
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
Edgar Allan Poe/Sullivan's Island Library
9 a.m. - 6 p.m.
Phone: (843) 883-3914
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
McClellanville Library
Closed for renovations
Phone: (843) 887-3699
Edisto Library
9 a.m. - 6 p.m.
Phone: (843) 869-2355
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Baxter-Patrick James Island
9 p.m. - 8 p.m.
Phone: (843) 795-6679
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa.
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- Author(s): Carroll MW;Carroll MW; Matthews DA; Matthews DA; Hiscox JA; Hiscox JA; Elmore MJ; Elmore MJ; Pollakis G; Pollakis G; Rambaut A; Rambaut A; Hewson R; Hewson R; García-Dorival I; García-Dorival I; Bore JA; Bore JA; Koundouno R; Koundouno R; Abdellati S; Abdellati S; Afrough B; Afrough B; Aiyepada J; Aiyepada J; Akhilomen P; Akhilomen P; Asogun D; Asogun D; Atkinson B; Atkinson B; Badusche M; Badusche M; Bah A; Bah A; Bate S; Bate S; Baumann J; Baumann J; Becker D; Becker D; Becker-Ziaja B; Becker-Ziaja B; Bocquin A; Bocquin A; Borremans B; Borremans B; Bosworth A; Bosworth A; Boettcher JP; Boettcher JP; Cannas A; Cannas A; Carletti F; Carletti F; Castilletti C; Castilletti C; Clark S; Clark S; Colavita F; Colavita F; Diederich S; Diederich S; Donatus A; Donatus A; Duraffour S; Duraffour S; Ehichioya D; Ehichioya D; Ellerbrok H; Ellerbrok H; Fernandez-Garcia MD; Fernandez-Garcia MD; Fizet A; Fizet A; Fleischmann E; Fleischmann E; Gryseels S; Gryseels S; Hermelink A; Hermelink A; Hinzmann J; Hinzmann J; Hopf-Guevara U; Hopf-Guevara U; Ighodalo Y; Ighodalo Y; Jameson L; Jameson L; Kelterbaum A; Kelterbaum A; Kis Z; Kis Z; Kloth S; Kloth S; Kohl C; Kohl C; Korva M; Korva M; Kraus A; Kraus A; Kuisma E; Kuisma E; Kurth A; Kurth A; Liedigk B; Liedigk B; Logue CH; Logue CH; Lüdtke A; Lüdtke A; Maes P; Maes P; McCowen J; McCowen J; Mély S; Mély S; Mertens M; Mertens M; Meschi S; Meschi S; Meyer B; Meyer B; Michel J; Michel J; Molkenthin P; Molkenthin P; Muñoz-Fontela C; Muñoz-Fontela C; Muth D; Muth D; Newman EN; Newman EN; Ngabo D; Ngabo D; Oestereich L; Oestereich L; Okosun J; Okosun J; Olokor T; Olokor T; Omiunu R; Omiunu R; Omomoh E; Omomoh E; Pallasch E; Pallasch E; Pályi B; Pályi B; Portmann J; Portmann J; Pottage T; Pottage T; Pratt C; Pratt C; Priesnitz S; Priesnitz S; Quartu S; Quartu S; Rappe J; Rappe J; Repits J; Repits J; Richter M; Richter M; Rudolf M; Rudolf M; Sachse A; Sachse A; Schmidt KM; Schmidt KM; Schudt G; Schudt G; Strecker T; Strecker T; Thom R; Thom R; Thomas S; Thomas S; Tobin E; Tobin E; Tolley H; Tolley H; Trautner J; Trautner J; Vermoesen T; Vermoesen T; Vitoriano I; Vitoriano I; Wagner M; Wagner M; Wolff S; Wolff S; Yue C; Yue C; Capobianchi MR; Capobianchi MR; Kretschmer B; Kretschmer B; Hall Y; Hall Y; Kenny JG; Kenny JG; Rickett NY; Rickett NY; Dudas G; Dudas G; Coltart CE; Coltart CE; Kerber R; Kerber R; Steer D; Steer D; Wright C; Wright C; Senyah F; Senyah F; Keita S; Keita S; Drury P; Drury P; Diallo B; Diallo B; de Clerck H; de Clerck H; Van Herp M; Van Herp M; Sprecher A; Sprecher A; Traore A; Traore A; Diakite M; Diakite M; Konde MK; Konde MK; Koivogui L; Koivogui L; Magassouba N; Magassouba N; Avšič-Županc T; Avšič-Županc T; Nitsche A; Nitsche A; Strasser M; Strasser M; Ippolito G; Ippolito G; Becker S; Becker S; Stoecker K; Stoecker K; Gabriel M; Gabriel M; Raoul H; Raoul H; Di Caro A; Di Caro A; Wölfel R; Wölfel R; Formenty P; Formenty P; Günther S; Günther S
- Source:
Nature [Nature] 2015 Aug 06; Vol. 524 (7563), pp. 97-101. Date of Electronic Publication: 2015 Jun 17.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
- Publication Information: Publication: Basingstoke : Nature Publishing Group
Original Publication: London, Macmillan Journals ltd. - Subject Terms: Evolution, Molecular* ; Phylogeny* ; Spatio-Temporal Analysis*; Disease Outbreaks/*statistics & numerical data ; Ebolavirus/*genetics ; Hemorrhagic Fever, Ebola/*epidemiology ; Hemorrhagic Fever, Ebola/*virology; Amino Acid Substitution/genetics ; Ebolavirus/isolation & purification ; Female ; Guinea/epidemiology ; Hemorrhagic Fever, Ebola/transmission ; High-Throughput Nucleotide Sequencing ; Humans ; Liberia/epidemiology ; Male ; Mali/epidemiology ; Molecular Sequence Data ; Sierra Leone/epidemiology
- Abstract: West Africa is currently witnessing the most extensive Ebola virus (EBOV) outbreak so far recorded. Until now, there have been 27,013 reported cases and 11,134 deaths. The origin of the virus is thought to have been a zoonotic transmission from a bat to a two-year-old boy in December 2013 (ref. 2). From this index case the virus was spread by human-to-human contact throughout Guinea, Sierra Leone and Liberia. However, the origin of the particular virus in each country and time of transmission is not known and currently relies on epidemiological analysis, which may be unreliable owing to the difficulties of obtaining patient information. Here we trace the genetic evolution of EBOV in the current outbreak that has resulted in multiple lineages. Deep sequencing of 179 patient samples processed by the European Mobile Laboratory, the first diagnostics unit to be deployed to the epicentre of the outbreak in Guinea, reveals an epidemiological and evolutionary history of the epidemic from March 2014 to January 2015. Analysis of EBOV genome evolution has also benefited from a similar sequencing effort of patient samples from Sierra Leone. Our results confirm that the EBOV from Guinea moved into Sierra Leone, most likely in April or early May. The viruses of the Guinea/Sierra Leone lineage mixed around June/July 2014. Viral sequences covering August, September and October 2014 indicate that this lineage evolved independently within Guinea. These data can be used in conjunction with epidemiological information to test retrospectively the effectiveness of control measures, and provides an unprecedented window into the evolution of an ongoing viral haemorrhagic fever outbreak.
- References: Mol Biol Evol. 2013 Mar;30(3):713-24. (PMID: 23180580)
Nat Methods. 2012 Mar 04;9(4):357-9. (PMID: 22388286)
Genome Biol. 2010;11(8):R86. (PMID: 20738864)
Syst Biol. 2012 May;61(3):539-42. (PMID: 22357727)
Mol Biol Evol. 2005 Jul;22(7):1561-8. (PMID: 15814826)
Genome Biol. 2014;15(11):532. (PMID: 25398248)
N Engl J Med. 2014 Nov 27;371(22):2092-100. (PMID: 25353969)
PLoS Biol. 2006 May;4(5):e88. (PMID: 16683862)
Mol Biol Evol. 2012 Aug;29(8):1969-73. (PMID: 22367748)
Science. 2015 Apr 3;348(6230):117-9. (PMID: 25814067)
J Proteome Res. 2014 Nov 7;13(11):5120-35. (PMID: 25158218)
N Engl J Med. 2014 Oct 9;371(15):1418-25. (PMID: 24738640)
J Infect Dis. 2011 Nov;204 Suppl 3:S1011-20. (PMID: 21987737)
J Interferon Cytokine Res. 2009 Sep;29(9):511-20. (PMID: 19694547)
J Comput Biol. 2013 Feb;20(2):113-23. (PMID: 23383997)
Evid Based Med. 2015 Feb;20(1):28. (PMID: 25525042)
J Mol Evol. 1994 Sep;39(3):306-14. (PMID: 7932792)
Science. 2014 Sep 12;345(6202):1369-72. (PMID: 25214632)
Genome Biol. 2014;15(11):540. (PMID: 25416632) - Grant Information: 001 International WHO_ World Health Organization; 095831 United Kingdom WT_ Wellcome Trust
- Molecular Sequence: GENBANK KR817067; KR817068; KR817069; KR817070; KR817071; KR817072; KR817073; KR817074; KR817075; KR817076; KR817077; KR817078; KR817079; KR817080; KR817081; KR817082; KR817083; KR817084; KR817085; KR817086; KR817087; KR817088; KR817089; KR817090; KR817091; KR817092; KR817093; KR817094; KR817095; KR817096; KR817097; KR817098; KR817099; KR817100; KR817101; KR817102; KR817103; KR817104; KR817105; KR817106; KR817107; KR817108; KR817109; KR817110; KR817111; KR817112; KR817113; KR817114; KR817115; KR817116; KR817117; KR817118; KR817119; KR817120; KR817121; KR817122; KR817123; KR817124; KR817125; KR817126; KR817127; KR817128; KR817129; KR817130; KR817131; KR817132; KR817133; KR817134; KR817135; KR817136; KR817137; KR817138; KR817139; KR817140; KR817141; KR817142; KR817143; KR817144; KR817145; KR817146; KR817147; KR817148; KR817149; KR817150; KR817151; KR817152; KR817153; KR817154; KR817155; KR817156; KR817157; KR817158; KR817159; KR817160; KR817161; KR817162; KR817163; KR817164; KR817165; KR817166; KR817167; KR817168; KR817169; KR817170; KR817171; KR817172; KR817173; KR817174; KR817175; KR817176; KR817177; KR817178; KR817179; KR817180; KR817181; KR817182; KR817183; KR817184; KR817185; KR817186; KR817187; KR817188; KR817189; KR817190; KR817191; KR817192; KR817193; KR817194; KR817195; KR817196; KR817197; KR817198; KR817199; KR817200; KR817201; KR817202; KR817203; KR817204; KR817205; KR817206; KR817207; KR817208; KR817209; KR817210; KR817211; KR817212; KR817213; KR817214; KR817215; KR817216; KR817217; KR817218; KR817219; KR817220; KR817221; KR817222; KR817223; KR817224; KR817225; KR817226; KR817227; KR817228; KR817229; KR817230; KR817231; KR817232; KR817233; KR817234; KR817235; KR817236; KR817237; KR817238; KR817239; KR817240; KR817241; KR817242; KR817243; KR817244; KR817245
- Publication Date: Date Created: 20150618 Date Completed: 20160501 Latest Revision: 20231028
- Publication Date: 20240104
- Accession Number: PMC10601607
- Accession Number: 10.1038/nature14594
- Accession Number: 26083749
- Source:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.