Antioxidative Role of Hatikana (Leea macrophylla Roxb.) Partially Improves the Hepatic Damage Induced by CCl4 in Wistar Albino Rats.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Source:
      Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, NY : Hindawi Pub. Co.
    • Subject Terms:
    • Abstract:
      This research investigated the protective role of Leea macrophylla extract on CCl4-induced acute liver injury in rats. Different fractions of Leea macrophylla (Roxb.) crude extract were subjected to analysis for antioxidative effects. Rats were randomly divided into four groups as normal control, hepatic control, and reference control (silymarin) group and treatment group. Evaluations were made for the effects of the fractions on serum enzymes and biochemical parameters of CCl4-induced albino rat. Histopathological screening was also performed to evaluate the changes of liver tissue before and after treatment. Different fractions of Leea macrophylla showed very potent 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging effect, FeCl3 reducing effect, superoxide scavenging effect, and iron chelating effect. Carbon tetrachloride induction increased the level of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) and other biochemical parameters such as lipid profiles, total protein, and CK-MB. In contrast, treatment of Leea macrophylla reduced the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) activities as well as biochemical parameters activities. L. macrophylla partially restored the lipid profiles, total protein, and CK-MB. Histopathology showed the treated liver towards restoration. Results evidenced that L. macrophylla can be prospective source of hepatic management in liver injury.
    • References:
      Indian J Hist Sci. 1981;16(2):219-22. (PMID: 11611447)
      Phytochem Anal. 2002 Jan-Feb;13(1):8-17. (PMID: 11899609)
      Phytomedicine. 2002 Jan;9(1):69-74. (PMID: 11924767)
      J Agric Food Chem. 2002 Apr 10;50(8):2454-8. (PMID: 11929313)
      Free Radic Biol Med. 2003 Jan 1;34(1):1-10. (PMID: 12498974)
      Fitoterapia. 2003 Sep;74(6):578-82. (PMID: 12946721)
      Biol Pharm Bull. 2004 Jan;27(1):38-46. (PMID: 14709896)
      Acta Pharm. 2005 Sep;55(3):297-304. (PMID: 16375840)
      Life Sci. 2006 Sep 5;79(15):1456-65. (PMID: 16698044)
      J Ethnopharmacol. 2007 Sep 5;113(2):284-91. (PMID: 17686593)
      Food Chem Toxicol. 2008 Nov;46(11):3429-42. (PMID: 18812207)
      J Biol Chem. 1990 May 25;265(15):8392-9. (PMID: 2140358)
      Asian Pac J Trop Med. 2012 Jul;5(7):533-8. (PMID: 22647815)
      Indian J Clin Biochem. 1999 Jan;14(1):59-90. (PMID: 23105203)
      Asian Pac J Trop Biomed. 2012 Mar;2(3):176-80. (PMID: 23569893)
      Pharm Biol. 2013 Jul;51(7):906-13. (PMID: 23627467)
      Food Chem Toxicol. 2013 Sep;59:514-20. (PMID: 23831308)
      Saudi J Biol Sci. 2013 Jul;20(3):213-25. (PMID: 23961238)
      J Agric Food Chem. 1998 May;46(5):1887-1892. (PMID: 29072454)
      Anal Biochem. 1979 Jun;95(2):351-8. (PMID: 36810)
      Anal Biochem. 1996 Jul 15;239(1):70-6. (PMID: 8660627)
    • Accession Number:
      0 (Antioxidants)
      0 (Biphenyl Compounds)
      0 (Chlorides)
      0 (Ferric Compounds)
      0 (Free Radical Scavengers)
      0 (Iron Chelating Agents)
      0 (Picrates)
      0 (Plant Extracts)
      11062-77-4 (Superoxides)
      97C5T2UQ7J (Cholesterol)
      CL2T97X0V0 (Carbon Tetrachloride)
      DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
      EC (Alanine Transaminase)
      EC (Creatine Kinase, MB Form)
      EC (Alkaline Phosphatase)
      U38V3ZVV3V (ferric chloride)
      YOW8V9698H (Dimethyl Sulfoxide)
    • Publication Date:
      Date Created: 20150730 Date Completed: 20160503 Latest Revision: 20190111
    • Publication Date:
    • Accession Number:
    • Accession Number:
    • Accession Number: