Flotillin-2 Gene Is Associated with Coronary Artery Disease in Chinese Han Population.

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  • Additional Information
    • Source:
      Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101494210 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-0257 (Electronic) Linking ISSN: 19450257 NLM ISO Abbreviation: Genet Test Mol Biomarkers Subsets: MEDLINE
    • Publication Information:
      Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc.
    • Subject Terms:
      Polymorphism, Single Nucleotide*; Coronary Artery Disease/*genetics ; Membrane Proteins/*genetics; Aged ; Asian People/ethnology ; Asian People/genetics ; China/ethnology ; Cholesterol/blood ; Coronary Artery Disease/blood ; Coronary Artery Disease/ethnology ; Female ; Humans ; Male ; Membrane Proteins/metabolism ; Middle Aged ; Risk Factors
    • Abstract:
      Background: Flotillin-2, an important protein of vesicular endocytosis, is commonly used as a marker protein for lipid microdomains. It plays an essential role in cellular cholesterol uptake and biliary cholesterol reabsorption. Excessive cholesterol intake could cause dyslipidemia, which is a major risk factor of coronary artery disease (CAD).
      Aims: To investigate the association between the human flotillin-2 gene polymorphism and CAD in the Chinese Han population.
      Materials and Methods: Three single-nucleotide polymorphisms (SNPs; rs10205, rs3816848 and rs8081659) of the flotillin-2 gene were genotyped by real-time polymerase chain reaction in 307 CAD patients and 441 control subjects.
      Results: The genotypic distribution of these three SNPs was significantly different between CAD patients and control subjects (all p < 0.05). There were significant differences in the plasma levels of total cholesterol (TC) among different genotypes in the CAD group and control group. For rs3816848, CAD patients with the GG genotype had a higher level of TC than those with an AG or AA genotype (p < 0.001). For rs8081659, CAD patients with TT genotype had a higher level of TC than those with a CT or CC genotype (p < 0.001). Multiple logistic regression analysis showed that the GG genotype of rs3816848 was an independent risk factor for CAD (odds ratio [OR] = 1.786; 95% CI = 1.099-2.902; p = 0.019).
      Conclusion: There was a strong association between polymorphisms of flotillin-2 gene and CAD in the Chinese Han population. Persons with the GG genotype of rs3816848 may have a higher risk of CAD. Moreover, the plasma levels of TC were significantly different among the different genotypes of the rs3816848 and rs8081659 SNPs in the CAD group as well as the control group.
    • References:
      Mol Biol Cell. 2001 Oct;12(10):3031-45. (PMID: 11598189)
      Clin Biochem. 2009 Oct;42(15):1493-9. (PMID: 19631633)
      Curr Opin Lipidol. 2006 Dec;17(6):702-4. (PMID: 17095916)
      PLoS One. 2013;8(5):e62365. (PMID: 23658725)
      Cells. 2014 Feb 19;3(1):129-49. (PMID: 24709906)
      J Thromb Haemost. 2010 Nov;8(11):2358-68. (PMID: 20695980)
      Am J Pathol. 2004 Nov;165(5):1465-77. (PMID: 15509518)
      Cancer Res. 2004 Oct 15;64(20):7361-9. (PMID: 15492257)
      Biochem J. 2004 Mar 1;378(Pt 2):509-18. (PMID: 14599293)
      Prim Care. 2013 Mar;40(1):195-211. (PMID: 23402469)
      Circulation. 1998 May 12;97(18):1837-47. (PMID: 9603539)
      FEBS J. 2014 May;281(9):2214-27. (PMID: 24605801)
      Int J Med Sci. 2013;10(10):1259-70. (PMID: 23983584)
      Trends Cell Biol. 2007 Aug;17(8):394-402. (PMID: 17766116)
      J Neurobiol. 1998 Dec;37(4):502-23. (PMID: 9858255)
      Circulation. 2011 Feb 1;123(4):e18-e209. (PMID: 21160056)
      Oncogene. 2013 Jul 18;32(29):3443-51. (PMID: 22869152)
      Cardiovasc Res. 2003 Aug 1;59(2):277-87. (PMID: 12909311)
      Development. 1997 Jan;124(2):577-87. (PMID: 9053333)
      J Clin Endocrinol Metab. 2002 Feb;87(2):423-37. (PMID: 11836262)
      Blood. 2003 Dec 15;102(13):4336-44. (PMID: 12881314)
      Immunobiology. 2002 Mar;205(1):108-19. (PMID: 11999340)
      Cell Signal. 2009 Aug;21(8):1287-97. (PMID: 19318123)
      JAMA. 2007 Aug 15;298(7):776-85. (PMID: 17699011)
      Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):551-6. (PMID: 21187433)
      Curr Protein Pept Sci. 2011 Dec;12(8):725-35. (PMID: 22329548)
      Int J Biochem Cell Biol. 2001 Jan;33(1):53-64. (PMID: 11167132)
      Cell Mol Life Sci. 2005 Oct;62(19-20):2228-40. (PMID: 16091845)
      Circulation. 2010 Feb 23;121(7):e46-e215. (PMID: 20019324)
      Biochim Biophys Acta. 2009 Jul;1791(7):679-83. (PMID: 19272334)
      Cell Signal. 2014 Feb;26(2):198-207. (PMID: 24216609)
    • Accession Number:
      0 (Membrane Proteins)
      0 (flotillins)
      97C5T2UQ7J (Cholesterol)
    • Publication Date:
      Date Created: 20151112 Date Completed: 20160921 Latest Revision: 20221207
    • Publication Date:
      20240104
    • Accession Number:
      PMC4677510
    • Accession Number:
      10.1089/gtmb.2015.0121
    • Accession Number:
      26556629