Parenting, Socioeconomic Status Risk, and Later Young Adult Health: Exploration of Opposing Indirect Effects via DNA Methylation.

Publisher: Blackwell Publishers Country of Publication: United States NLM ID: 0372725 Publication Model: Print Cited Medium: Internet ISSN: 1467-8624 (Electronic) Linking ISSN: 00093920 NLM ISO Abbreviation: Child Dev Subsets: MEDLINE

Publication: Malden, MA : Blackwell Publishers
Original Publication: [Chicago, etc.] : Published by the University of Chicago Press for the Society for Research in Child Development [etc.]

Health Status* ; Parenting* ; Poverty* ; Rural Population* ; Social Class*; Black or African American/*genetics ; DNA Methylation/*genetics ; Epigenesis, Genetic/*genetics; Adolescent ; Adult ; Child ; Female ; Follow-Up Studies ; Humans ; Male ; Risk ; Young Adult

A sample of 398 African American youth, residing in rural counties with high poverty and unemployment, were followed from ages 11 to 19. Protective parenting was associated with better health, whereas elevated socioeconomic status (SES) risk was associated with poorer health at age 19. Genome-wide epigenetic variation assessed in young adulthood (age 19), was associated with both SES risk and protective parenting. Three categories of genes were identified whose methylation was associated with parenting, SES risk, and young adult health. Methylation was a significant mediator of the impact of parenting and SES risk on young adult health. Variation in mononuclear white blood cell types was also examined and controlled, showing that it did not account for observed effects of parenting and SES risk on health.
(© 2016 The Authors. Child Development © 2016 Society for Research in Child Development, Inc.)

Hum Exp Toxicol. 2002 Sep-Oct;21(9-10):499-505. (PMID: 12458907)
Nat Rev Immunol. 2011 Sep;11(9):625-32. (PMID: 21818124)
Child Dev. 2013 Jan-Feb;84(1):58-75. (PMID: 21883162)
Psychoneuroendocrinology. 2008 Jul;33(6):693-710. (PMID: 18602762)
Health Psychol. 2014 May;33(5):401-9. (PMID: 23668852)
Am Psychol. 2012 May-Jun;67(4):272-84. (PMID: 22583341)
BMC Genomics. 2013;14:293. (PMID: 23631413)
Dev Psychol. 2002 Mar;38(2):179-93. (PMID: 11881755)
Psychol Sci. 2011 Dec;22(12):1591-9. (PMID: 22123777)
Psychol Bull. 2002 Mar;128(2):330-66. (PMID: 11931522)
Psychol Sci. 2010 Jun;21(6):848-56. (PMID: 20431047)
Psychol Bull. 2011 Nov;137(6):959-97. (PMID: 21787044)
Health Econ. 1993 Oct;2(3):217-27. (PMID: 8275167)
Ann N Y Acad Sci. 1999;896:85-95. (PMID: 10681890)
J Am Acad Child Adolesc Psychiatry. 2005 Jan;44(1):19-27. (PMID: 15608540)
Child Dev. 2001 Jul-Aug;72(4):1231-46. (PMID: 11480944)
Child Dev. 1991 Aug;62(4):647-70. (PMID: 1935336)
Child Dev. 1994 Apr;65(2 Spec No):541-61. (PMID: 8013239)
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3080-5. (PMID: 21300872)
BMC Bioinformatics. 2012;13:86. (PMID: 22568884)
Trends Ecol Evol. 2005 Oct;20(10):527-33. (PMID: 16701430)
Endocr Rev. 2011 Apr;32(2):159-224. (PMID: 20971919)
PLoS One. 2012;7(7):e41361. (PMID: 22848472)
Psychosom Med. 2009 Feb;71(2):243-50. (PMID: 19188532)
J Pers Soc Psychol. 1989 Feb;56(2):267-83. (PMID: 2926629)
Am Psychol. 2001 Mar;56(3):227-38. (PMID: 11315249)
J Appl Behav Anal. 1979 Winter;12(4):691-700. (PMID: 541311)
Psychoneuroendocrinology. 2011 Apr;36(3):352-71. (PMID: 20650569)
Biol Psychiatry. 2012 Jul 1;72(1):34-40. (PMID: 22494534)
Mol Psychiatry. 2011 Jul;16(7):729-37. (PMID: 20479762)
Genome Biol. 2003;4(4):R28. (PMID: 12702209)
Trends Endocrinol Metab. 2007 Apr;18(3):94-9. (PMID: 17320410)
J Epidemiol Community Health. 2008 Jun;62(6):484-91. (PMID: 18477746)
Genome Biol. 2014;15(3):R50. (PMID: 24598480)
JAMA. 2009 Jun 3;301(21):2252-9. (PMID: 19491187)
Am J Public Health. 2010 Apr 1;100 Suppl 1:S186-96. (PMID: 20147693)

P30 DA027827 United States DA NIDA NIH HHS; R01 HD030588 United States HD NICHD NIH HHS; 1P30DA027827 United States DA NIDA NIH HHS; 5R01HD030588-16A1 United States HD NICHD NIH HHS

Date Created: 20160130 Date Completed: 20161213 Latest Revision: 20221207

20240104

PMC4733891

10.1111/cdev.12486

26822447