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Epidemiology and Outcomes of Complicated Skin and Soft Tissue Infections among Inpatients in Southern China from 2008 to 2013.
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- Author(s): Li X;Li X; Chen Y; Chen Y; Gao W; Gao W; Ouyang W; Ouyang W; Wei J; Wei J; Wen Z; Wen Z
- Source:
PloS one [PLoS One] 2016 Feb 26; Vol. 11 (2), pp. e0149960. Date of Electronic Publication: 2016 Feb 26 (Print Publication: 2016).- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
- Publication Information: Original Publication: San Francisco, CA : Public Library of Science
- Subject Terms: Anti-Bacterial Agents/*therapeutic use ; Skin Diseases, Bacterial/*drug therapy ; Skin Diseases, Bacterial/*economics ; Skin Diseases, Bacterial/*epidemiology ; Soft Tissue Infections/*epidemiology; Aged ; China/epidemiology ; Cost of Illness ; Drug Resistance, Multiple, Bacterial ; Escherichia coli/drug effects ; Female ; Hospitalization/economics ; Humans ; Inpatients ; Klebsiella pneumoniae/drug effects ; Length of Stay/economics ; Male ; Middle Aged ; Retrospective Studies ; Soft Tissue Infections/drug therapy ; Soft Tissue Infections/economics ; Staphylococcus aureus/drug effects ; Treatment Outcome
- Abstract: Complicated skin and soft tissue infections (cSSTI) are some of the most commonly treated infections in hospitals, and place heavy economic burdens on patients and society. Here we report the findings from an analysis of cSSTI based on a retrospective study which was conducted within the Chinese inpatient population. We focused our research on the analysis of the patient population, antibiotic treatment, clinical outcome and economic burden. The study population comprised 527 selected patients hospitalized between 2008 and 2013. Among the hospitalizations with microbiological diagnoses, 61.41% (n = 113) were diagnosed as infected with Gram-positive bacteria, while 46.20% (n = 85) were infected with Gram-negative bacteria. The most commonly found Gram-positive bacteria was Staphylococcus aureus (40.76%, n = 75), and the most common Gram-negative bacteria was Escherichia coli (14.13%, n = 26). About 20% of the Staphylococcus aureus were methicillin-resistant. The resistance rate of isolated Staphylococcus aureus or Escherichia coli to penicillin was around 90%; in contrast, the resistance rate to vancomycin, linezolid or imipenem was low (<20%). A large percentage of patients were treated with cephalosporins and fluoroquinolones, while vancomycin and imipenem were also included to treat drug-resistant pathogens. Over half of the hospitalizations (58.43%, n = 336) experienced treatment modifications. The cost to patients with antibiotic modifications was relatively higher than to those without. In conclusion, our study offers an analysis of the disease characteristics, microbiological diagnoses, treatment patterns and clinical outcomes of cSSTI in four hospitals in Guangdong Province, and sheds lights on the current clinical management of cSSTI in China.
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J Clin Microbiol. 2012 Feb;50(2):238-45. (PMID: 22116149) - Accession Number: 0 (Anti-Bacterial Agents)
- Publication Date: Date Created: 20160227 Date Completed: 20160808 Latest Revision: 20181113
- Publication Date: 20240104
- Accession Number: PMC4769280
- Accession Number: 10.1371/journal.pone.0149960
- Accession Number: 26918456
- Source:
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