Association between variants in nicotinic acetylcholine receptor genes and smoking cessation in a Chinese rural population.

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  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9208821 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0391 (Electronic) Linking ISSN: 10550496 NLM ISO Abbreviation: Am J Addict Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Wiley-Blackwell
      Original Publication: Washington, DC : American Psychiatric Press, c1992-
    • Subject Terms:
    • Abstract:
      Background and Objectives: Genetic studies have revealed a significant association between variants in nicotinic acetylcholine receptor (CHRN) genes and smoking cessation, but the results are inconsistent. In this study, we aimed to examine the relationship between single nucleotide polymorphisms (SNPs) in seven CHRN genes and smoking cessation in a Chinese rural population.
      Methods: Participants were recruited from 17 villages of 3 counties in Shandong, China. DNA was extracted from the blood samples. Thirty-two SNPs in seven CHRN genes were genotyped. Logistic regression was used to explore the relationship between single SNP and smoking cessation. Pearson's χ(2) test was performed to test the association between haplotype and smoking cessation.
      Results: Rs578776 (in CHRNA3), rs660652 (in CHRNA3), and rs588765 (in CHRNA5) were significantly related to smoking cessation. Two haplotypes were associated with smoking cessation.
      Conclusions: This study confirmed the association between CHRN genes and smoking cessation in the Chinese rural population.
      Scientific Significance: Our findings provide confirmatory support to the role of CHRN genes to the etiology of smoking cessation in the Chinese rural population. (Am J Addict 2016;25:297-300).
      (© 2016 American Academy of Addiction Psychiatry.)
    • Accession Number:
      0 (Genetic Markers)
      0 (Receptors, Nicotinic)
    • Publication Date:
      Date Created: 20160521 Date Completed: 20171102 Latest Revision: 20181202
    • Publication Date:
      20240104
    • Accession Number:
      10.1111/ajad.12383
    • Accession Number:
      27197960