Medication understanding, non-adherence, and clinical outcomes among adult kidney transplant recipients.

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  • Additional Information
    • Source:
      Publisher: Munksgaard Country of Publication: Denmark NLM ID: 8710240 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-0012 (Electronic) Linking ISSN: 09020063 NLM ISO Abbreviation: Clin Transplant Subsets: MEDLINE
    • Publication Information:
      Original Publication: Copenhagen : Munksgaard,
    • Subject Terms:
    • Abstract:
      We sought to evaluate the prevalence of medication understanding and non-adherence of entire drug regimens among kidney transplantation (KT) recipients and to examine associations of these exposures with clinical outcomes. Structured, in-person interviews were conducted with 99 adult KT recipients between 2011 and 2012 at two transplant centers in Chicago, IL; and Atlanta, GA. Nearly, one-quarter (24%) of participants had limited literacy as measured by the Rapid Estimate of Adult Literacy in Medicine test; patients took a mean of 10 (SD=4) medications and 32% had a medication change within the last month. On average, patients knew what 91% of their medications were for (self-report) and demonstrated proper dosing (via observed demonstration) for 83% of medications. Overall, 35% were non-adherent based on either self-report or tacrolimus level. In multivariable analyses, fewer months since transplant and limited literacy were associated with non-adherence (all P<.05). Patients with minority race, a higher number of medications, and mild cognitive impairment had significantly lower treatment knowledge scores. Non-white race and lower income were associated with higher rates of hospitalization within a year following the interview. The identification of factors that predispose KT recipients to medication misunderstanding, non-adherence, and hospitalization could help target appropriate self-care interventions.
      Competing Interests: None.
      (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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    • Grant Information:
      L60 MD007236 United States MD NIMHD NIH HHS; P30 CA060553 United States CA NCI NIH HHS; R21 NR014544 United States NR NINR NIH HHS; T32 DK077662 United States DK NIDDK NIH HHS
    • Contributed Indexing:
      Keywords: cognition; hospitalization; kidney transplantation; literacy; medication adherence
    • Accession Number:
      0 (Immunosuppressive Agents)
    • Publication Date:
      Date Created: 20160723 Date Completed: 20180117 Latest Revision: 20220330
    • Publication Date:
      20240104
    • Accession Number:
      PMC5061615
    • Accession Number:
      10.1111/ctr.12821
    • Accession Number:
      27447351