Subclinical Hypothyroidism and Metabolic Syndrome: A Common Association by Chance or a Cardiovascular Risk Driver?

Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101150318 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8518 (Electronic) Linking ISSN: 15404196 NLM ISO Abbreviation: Metab Syndr Relat Disord Subsets: MEDLINE

Original Publication: Larchmont, NY : Mary Ann Liebert, Inc., c2003-

Hypothyroidism/*complications ; Metabolic Syndrome/*complications; Cardiovascular Diseases/complications ; Cardiovascular Diseases/epidemiology ; Carotid Intima-Media Thickness ; Humans ; Hypothyroidism/epidemiology ; Metabolic Syndrome/epidemiology ; Prevalence ; Risk Factors

The metabolic syndrome (MS) and subclinical hypothyroidism (SCH) are highly prevalent in the general population. Cross-sectional epidemiological data suggest that a mutual association exists between the two, although the cause-effect relationship remains poorly elucidated. As SCH raises cholesterol, blood pressure, and visceral fat, it is easy to understand why it associates with MS. Rather, the reasons whereby MS patients are at higher risk for SCH are less apparent. Some studies have reported that SCH is itself characterized by high cardiovascular risk. Therefore, the coexistence of SCH and MS may identify subjects at a particularly high risk for future cardiovascular events. Recent data published in Metabolic Syndrome and Related Disorders indicate that carotid intima-media thickness, a marker of initial atherosclerosis and a possible predictor of future events, is higher in patients with both SCH and MS than in the presence of each condition alone. In this Editorial, we discuss the clinical implications of SCH and MS association and the interpretation of such recent findings.

Comment on: Metab Syndr Relat Disord. 2016 Oct;14 (8):381-385. (PMID: 27228324)

Date Created: 20160824 Date Completed: 20171116 Latest Revision: 20180110

20240104

10.1089/met.2016.29009.bon

27551743