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Evaluation of cytotoxic, analgesic, antidiarrheal and phytochemical properties of Hygrophila spinosa (T. Anders) whole plant.
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- Author(s): Bellah SM; Islam MN; Karim MR; Rahaman MM; Nasrin MS; Rahman MA; Reza AS
- Source:
Journal of basic and clinical physiology and pharmacology [J Basic Clin Physiol Pharmacol] 2017 Mar 01; Vol. 28 (2), pp. 185-190.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Walter de Gruyter Country of Publication: Germany NLM ID: 9101750 Publication Model: Print Cited Medium: Internet ISSN: 2191-0286 (Electronic) Linking ISSN: 07926855 NLM ISO Abbreviation: J Basic Clin Physiol Pharmacol Subsets: MEDLINE
- Publication Information: Publication: Jun. 2011- : Berlin : Walter de Gruyter
Original Publication: London, England : Freund Pub. House, c1990- - Subject Terms: Acanthaceae*; Analgesics/*toxicity ; Antidiarrheals/*toxicity ; Pain Measurement/*drug effects ; Phytochemicals/*toxicity ; Plant Extracts/*toxicity; Analgesics/isolation & purification ; Analgesics/therapeutic use ; Animals ; Antidiarrheals/isolation & purification ; Antidiarrheals/therapeutic use ; Artemia ; Diarrhea/drug therapy ; Diarrhea/pathology ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical/methods ; Female ; Male ; Mice ; Pain Measurement/methods ; Phytochemicals/isolation & purification ; Phytochemicals/therapeutic use ; Plant Extracts/isolation & purification ; Plant Extracts/therapeutic use ; Plant Structures ; Toxicity Tests, Acute/methods
- Abstract: Background: Synthetic drugs are going to be replaced by plant-derived traditional drugs due to their cost effectiveness, relatively less harmfulness, and efficacy against multidrug resistance organisms. Hygrophila spinosa (Acanthaceae) has been used in a wide range of ailments including flatulence, diarrhea, dysentery, gonorrhea, and menorrhagia. Therefore, we investigated the cytotoxic, antinociceptive, and antidiarrheal effects of H. spinosa ethanol extract (EExHs).
Methods: Preliminary phytochemical screening was accomplished by established methods modified in experimental protocol. EExHs was undertaken for cytotoxic assay by Brine shrimp lethality bioassay, antinociceptive action by acetic acid induced writhing test, and antidiarrheal activity by castor oil induced antidiarrheal test. Data were analyzed by GraphPad Prism 6.0 software using Dunnett's test for multiple comparisons.
Results: Reducing sugar, steroid, glycoside, tannin, alkaloid, saponins, and flavonoids were found to be present in EExHs. Lethal concentration (LC50) of EExHs for brine shrimps was 50.59 µg/mL which was relatively lower than that of the standard drug vincristine sulfate. In acetic acid induced writhing test, oral administration of EExHs at three different doses (125, 250, and 500 mg/kg) decreased writhing in dose-dependent manner while the highest dose (500 mg/kg) achieved the maximum percentages of pain inhibition (58.8%). Diclofenac sodium (25 mg/kg) was used as a reference antinociceptive drug. The antidiarrheal action of EExHs was not found to be very promising for further use; however, the pure compounds from EExHs could be analyzed to justify the effects.
Conclusions: This research demonstrates that the secondary metabolites guided cytotoxic and analgesic effects could be extensively studied in multiple models to confirm the effects. - Accession Number: 0 (Analgesics)
0 (Antidiarrheals)
0 (Phytochemicals)
0 (Plant Extracts) - Publication Date: Date Created: 20161106 Date Completed: 20170707 Latest Revision: 20170707
- Publication Date: 20240105
- Accession Number: 10.1515/jbcpp-2016-0103
- Accession Number: 27815960
- Source:
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