Antiobesity Effects of Sansa (Crataegi fructus) on 3T3-L1 Cells and on High-Fat-High-Cholesterol Diet-Induced Obese Rats.

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  • Additional Information
    • Source:
      Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 9812512 Publication Model: Print Cited Medium: Internet ISSN: 1557-7600 (Electronic) Linking ISSN: 1096620X NLM ISO Abbreviation: J Med Food Subsets: MEDLINE
    • Publication Information:
      Original Publication: Larchmont, NY : Mary Ann Liebert, Inc., c1998-
    • Subject Terms:
      Adipocytes/*metabolism ; Anti-Obesity Agents/*administration & dosage ; Cholesterol/*metabolism ; Crataegus/*chemistry ; Obesity/*drug therapy ; Plant Extracts/*administration & dosage; 3T3-L1 Cells ; Adipocytes/drug effects ; Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Animals ; Cholesterol/analysis ; Diet, High-Fat/adverse effects ; Humans ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Obesity/metabolism ; Rats ; Rats, Sprague-Dawley ; Triglycerides/metabolism
    • Abstract:
      This study was performed to investigate the effects of Crataegi fructus ethanol extracts (CFEEs) on the differentiation of 3T3-L1 cells, and to evaluate the effects of C. fructus powder (CFP) on lipid metabolism and its antiobesity effect in rats fed a high-fat and high-cholesterol (HFC) diet. Both in vitro and in vivo studies were performed for physiological activity and antiobesity effects on the serum, liver, and adipose tissues in obesity-induced rats. CFEEs showed significant inhibitory action on differentiation and triglyceride (TG) accumulation in 3T3-L1 mature cells in a dose-dependent manner. Subcutaneous, mesenteric, epididymal, and total adipose tissue weights of HFC diet group were heavier than those of normal diet (N) group, whereas those of groups fed CFP were significantly decreased. Levels of serum TGs, total cholesterol (TC), and low-density lipoprotein cholesterol were significantly decreased in the CFP groups than in the HFC group, whereas the serum high-density lipoprotein cholesterol level decreased in the HFC group and markedly increased in the CFP groups. TC and TG levels in the liver and adipose tissues were significantly lower in CFP groups than in the HFC groups. In addition, feeding with CFP significantly reduced the occurrence of fatty liver deposits and steatosis, and inhibited an HFC diet-induced increase in adipocyte size. These results suggest that C. fructus may improve lipid metabolism in the serum, liver, and adipose tissue, and may potentially reduce lipid storage.
    • Contributed Indexing:
      Keywords: Crataegi fructus; adipocytes size; fat accumulation; lipid; obesity
    • Accession Number:
      0 (Anti-Obesity Agents)
      0 (Plant Extracts)
      0 (Triglycerides)
      6OM09RPY36 (crataegus extract)
      97C5T2UQ7J (Cholesterol)
    • Publication Date:
      Date Created: 20170119 Date Completed: 20170512 Latest Revision: 20170512
    • Publication Date:
      20240104
    • Accession Number:
      10.1089/jmf.2016.3791
    • Accession Number:
      28098517