Clinically useful brain imaging for neuropsychiatry: How can we get there?

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  • Additional Information
    • Source:
      Publisher: Wiley Country of Publication: United States NLM ID: 9708816 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6394 (Electronic) Linking ISSN: 10914269 NLM ISO Abbreviation: Depress Anxiety Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, NY : Wiley, c1997-
    • Subject Terms:
    • Abstract:
      Despite decades of research, visions of transforming neuropsychiatry through the development of brain imaging-based "growth charts" or "lab tests" have remained out of reach. In recent years, there is renewed enthusiasm about the prospect of achieving clinically useful tools capable of aiding the diagnosis and management of neuropsychiatric disorders. The present work explores the basis for this enthusiasm. We assert that there is no single advance that currently has the potential to drive the field of clinical brain imaging forward. Instead, there has been a constellation of advances that, if combined, could lead to the identification of objective brain imaging-based markers of illness. In particular, we focus on advances that are helping to (1) elucidate the research agenda for biological psychiatry (e.g., neuroscience focus, precision medicine), (2) shift research models for clinical brain imaging (e.g., big data exploration, standardization), (3) break down research silos (e.g., open science, calls for reproducibility and transparency), and (4) improve imaging technologies and methods. Although an arduous road remains ahead, these advances are repositioning the brain imaging community for long-term success.
      (© 2017 Wiley Periodicals, Inc.)
    • Grant Information:
      U01 MH099059 United States MH NIMH NIH HHS
    • Contributed Indexing:
      Keywords: assessment/diagnosis; biological markers; brain imaging/neuroimaging; dissemination/implementation; functional MRI; neuroimaging
    • Publication Date:
      Date Created: 20170421 Date Completed: 20180313 Latest Revision: 20181202
    • Publication Date:
      20240105
    • Accession Number:
      10.1002/da.22627
    • Accession Number:
      28426908