Low-Dose Aspirin Reduces Breast Cancer Risk in Women with Diabetes: A Nationwide Retrospective Cohort Study in Taiwan.

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    • Source:
      Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101159262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-843X (Electronic) Linking ISSN: 15409996 NLM ISO Abbreviation: J Womens Health (Larchmt) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Larchmont, NY : Mary Ann Liebert, Inc., [2002]-
    • Subject Terms:
    • Abstract:
      Purpose: Low-dose aspirin is commonly used for preventing cardiovascular disease in people with diabetes, but its association with cancer remains controversial. This study used a nationwide population-based reimbursement database to investigate the relationship between low-dose aspirin use and breast cancer incidence in women with diabetes.
      Methods: This retrospective cohort study was conducted using data retrieved from the National Health Insurance Research Database in Taiwan from January 1, 1998 to December 31, 2011. Women diagnosed as having diabetes with low-dose aspirin use (75-165 mg daily) were identified as the study population, whereas those without low-dose aspirin use were selected as the comparison group.
      Results: We analyzed 148,739 patients with diabetes. Their mean age (standard deviation) was 63.3 (12.8) years. A total of 27,378 patients were taking aspirin. Overall, the use of aspirin in patients with diabetes reduced the risk of breast cancer by 18% (hazard ratio [HR], 0.82; 95% confidence interval [CI], 0.71-0.94) after adjustment for potential confounders, namely age and comorbidities. Specifically, a cumulative dose of aspirin exceeding 88,900 mg was observed to reduce the risk of breast cancer by 47% (HR, 0.53, 95% CI, 0.43-0.67); however, low (<8,600 mg) and medium (8,600-88,900 mg) cumulative doses of aspirin did not reduce the risk of breast cancer.
      Conclusions: Our findings suggest that a cumulative aspirin dosage of more than 88,900 mg daily was associated with a reduced risk of breast cancer in women with diabetes. However, additional studies are necessary to confirm these findings.
    • Comments:
      Comment in: J Womens Health (Larchmt). 2017 Dec;26(12 ):1364. (PMID: 29148880)
      Comment in: J Womens Health (Larchmt). 2018 Jun;27(6):844. (PMID: 29741979)
      Comment in: J Womens Health (Larchmt). 2018 Jun;27(6):845. (PMID: 29847742)
    • Contributed Indexing:
      Keywords: aspirin*; breast cancer*; diabetes*; nationwide cohort study*
    • Accession Number:
      0 (Anti-Inflammatory Agents, Non-Steroidal)
      0 (Hypoglycemic Agents)
      R16CO5Y76E (Aspirin)
    • Publication Date:
      Date Created: 20170525 Date Completed: 20180426 Latest Revision: 20180613
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