Biosynthesis of gold and silver chloride nanoparticles mediated by Crataegus pinnatifida fruit extract: in vitro study of anti-inflammatory activities.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 101594777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2169-141X (Electronic) Linking ISSN: 21691401 NLM ISO Abbreviation: Artif Cells Nanomed Biotechnol Subsets: MEDLINE
    • Publication Information:
      Publication: 2015- : Abingdon, Oxford : Taylor & Francis
      Original Publication: London : Informa Healthcare, [2013]-
    • Subject Terms:
      Anti-Inflammatory Agents*/chemistry ; Anti-Inflammatory Agents*/pharmacology ; Gold*/chemistry ; Gold*/pharmacology ; Silver Compounds*/chemistry ; Silver Compounds*/pharmacology; Crataegus/*chemistry ; Fruit/*chemistry ; Nanoparticles/*chemistry ; Plant Extracts/*chemistry; Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Escherichia coli/growth & development ; Mice ; RAW 264.7 Cells ; Staphylococcus aureus/growth & development
    • Abstract:
      This research article investigates the one-pot synthesis of gold and silver chloride nanoparticles functionalized by fruit extract of Crataegus pinnatifida as reducing and stabilizing agents and their possible roles as novel anti-inflammatory agents. Hawthorn (C. pinnatifida) fruits are increasingly popular as raw materials for functional foods and anti-inflammatory potential agents because of abundant flavonoids. The reduction of auric chloride and silver nitrate by the aqueous fruit extract led to the formation of gold and silver chloride nanoparticles. The nanoparticles were further characterized by field emission transmission electron microscopy indicated that CP-AuNps and CP-AgClNps were hexagonal and cubic shape, respectively. According to X-ray diffraction results, the average crystallite sizes of CP-AuNps and CP-AgClNps were 14.20 nm and 24.80 nm. The biosynthesized CP-AgClNps served as efficient antimicrobial agents against Escherichia coli and Staphylococcus aureus. Furthermore, CP-AuNps and CP-AgClNps enhanced the DPPH radical scavenging activity of the fruit extract. Lastly, MTT assay of nanoparticles demonstrated low toxicity in murine macrophage (RAW264.7). Biosynthesized nanoparticles also reduced the production of the inflammatory cytokines including nitric oxide and prostaglandin E2 in lipopolysaccharide-induced RAW264.7 cells. Altogether, these findings suggest that CP-AuNps and CP-AgClNps can be used as novel drug carriers or biosensors with intrinsic anti-inflammatory activity.
    • Contributed Indexing:
      Keywords: Crataegus pinnatifida; anti-inflammatory agents; antimicrobial activity; antioxidant activity; gold nanoparticles; silver chloride nanoparticles
    • Accession Number:
      0 (Anti-Bacterial Agents)
      0 (Anti-Inflammatory Agents)
      0 (Plant Extracts)
      0 (Silver Compounds)
      7440-57-5 (Gold)
      MWB0804EO7 (silver chloride)
    • Publication Date:
      Date Created: 20170919 Date Completed: 20190220 Latest Revision: 20190320
    • Publication Date:
      20240104
    • Accession Number:
      10.1080/21691401.2017.1376674
    • Accession Number:
      28918663