Paternal and maternal age as risk factors for schizophrenia: a case-control study.

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  • Additional Information
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 9709509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-1788 (Electronic) Linking ISSN: 13651501 NLM ISO Abbreviation: Int J Psychiatry Clin Pract Subsets: MEDLINE
    • Publication Information:
      Publication: London : Informa Healthcare
      Original Publication: London : Martin Dunitz, c1997-
    • Subject Terms:
    • Abstract:
      Objective: Advanced parental age might constitute a generic risk factor for mental and somatic disorders. The current study tested whether this concerns also patients with schizophrenia.
      Methods: A total of 231 schizophrenic, 56 other severe mental disorders patients and 204 controls were diagnosed according to DSM-IV-TR. Data were tested with ANOVA models including relative risk and odds ratios.
      Results: Patients with schizophrenia manifested higher paternal (32.55 ± 6.35 vs. 29.42 ± 6.07, p < .001) and maternal age (27.66 ± 5.57 vs. 25.46 ± 4.52, p < .001). Patients with other mental disorders had higher paternal (33.29 ± 8.35; p = .001) but not maternal age (26.69 ± 5.89; p = .296) compared to controls. There was no difference between the two patient groups concerning either paternal or maternal age (p > .05). There seems to be a higher risk for the development of schizophrenia in offspring with paternal age above 25 years and maternal age above 22 years at delivery.
      Conclusions: The current study provides further support for the suggestion that advanced paternal age constitutes a risk factor (in a non-dose dependent and gender-independent way) for the development of schizophrenia but also for other mental disorders. In contrast, advanced maternal age characterises schizophrenia specifically. The higher risk is evident after 25 years of paternal and 22 years of maternal age, respectively.
    • Contributed Indexing:
      Keywords: Schizophrenia; maternal age; parental age; paternal age
    • Publication Date:
      Date Created: 20171027 Date Completed: 20181109 Latest Revision: 20181109
    • Publication Date:
      20240104
    • Accession Number:
      10.1080/13651501.2017.1391292
    • Accession Number:
      29069946