Association between oxidative stress and cord serum lipids in relation to delayed cord clamping in term neonates.

Publisher: BioMed Central Country of Publication: England NLM ID: 101147696 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-511X (Electronic) Linking ISSN: 1476511X NLM ISO Abbreviation: Lipids Health Dis Subsets: MEDLINE

Original Publication: [London] : BioMed Central, 2002-

Oxidative Stress* ; Umbilical Cord*; Fetal Blood/*metabolism ; Term Birth/*blood; Adult ; Catalase/blood ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Constriction ; Cross-Sectional Studies ; Female ; Glutathione Peroxidase/blood ; Humans ; Infant, Newborn ; Male ; Phospholipids/blood ; Superoxide Dismutase/blood ; Time Factors ; Triglycerides/blood

Background: Although delayed cord clamping (DCC) is a recent WHO recommendation, early cord clamping (ECC) is still a routine practice in many countries. Limited researches studied the effect of delayed cord clamping on oxidative stress in term neonates; In this study we aim to assess the influence of cord clamping either early or late on oxidative stress in term neonates and to evaluate the association of oxidative stress and cord blood lipids.
Methods: One-hundred mothers and their term neonates were included in the present study. Umbilical cord blood samples were collected from the umbilical vein and umbilical artery immediately following labor.
Results: Total cholesterol, total triglycerides and phospholipids levels were significantly higher in the ECC group than the DCC group (p < 0.001 in all). Plasma total antioxidant status was higher in the DCC group than the ECC group (p < 0.001). While, plasma hydroperoxides were lower in the DCC group than the ECC group (p < 0.001). Levels of erythrocytes catalase cytosol, superoxide dismutase and glutathione peroxidase were significantly higher in the DCC group than the ECC group (p < 0.001).
Conclusion: DCC was associated with a decrease in cord blood lipids and an augmented antioxidant activity. This suggests the protective effect of DCC on the future health of the term neonates and supports the application of DCC in active management of 3rd stage of labor in term neonates.

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Keywords: Cord lipids; Delayed cord clamping; Oxidative stress; Term neonates

0 (Cholesterol, HDL)
0 (Cholesterol, LDL)
0 (Phospholipids)
0 (Triglycerides)
EC 1.11.1.6 (Catalase)
EC 1.11.1.9 (Glutathione Peroxidase)
EC 1.15.1.1 (Superoxide Dismutase)

Date Created: 20171111 Date Completed: 20180625 Latest Revision: 20240327

20240327

PMC5680750

10.1186/s12944-017-0599-y

29121952