Immunological Effect of aGV Rabies Vaccine Administered Using the Essen and Zagreb Regimens: A Double-Blind, Randomized Clinical Trial.

Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 8801552 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8976 (Electronic) Linking ISSN: 08828245 NLM ISO Abbreviation: Viral Immunol Subsets: MEDLINE

Original Publication: New York, NY : Mary Ann Liebert, Inc., c1987-

Immunization Schedule*; Rabies/*prevention & control ; Rabies Vaccines/*administration & dosage ; Rabies Vaccines/*immunology ; Rabies virus/*immunology; Adolescent ; Adult ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; Child ; Double-Blind Method ; Female ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; Seroconversion ; Young Adult

This study evaluated the immunological effect of an aGV rabies virus strain using the Essen and Zagreb immunization programs. A total of 1,944 subjects were enrolled and divided into three groups: the Essen test group, Essen control group, and Zagreb test group. Neutralizing antibody levels and antibody seroconversion rates were determined at 7 and 14 days after the initial inoculations and then 14 days after the final inoculation in all of the subjects. The seroconversion rates for the Essen test group, Essen control group, and Zagreb test group, which were assessed 7 days after the first dosing in a susceptible population, were 35.74%, 26.92%, and 45.49%, respectively, and at 14 days, the seroconversion rates in this population were 100%, 100%, and 99.63%, respectively. At 14 days after the final dosing, the seroconversion rates were 100% in all three of the groups. The neutralizing serum antibody levels of the Essen test group, Essen control group, and Zagreb test group at 7 days after the first dosing in the susceptible population were 0.37, 0.26, and 0.56 IU/mL, respectively, and at 14 days after the initial dosing, these levels were 16.71, 13.85, and 16.80 IU/mL. At 14 days after the final dosing, the neutralizing antibody levels were 22.9, 16.3, and 18.62 IU/mL, respectively. The results of this study suggested that the aGV rabies vaccine using the Essen program resulted in a good serum immune response, and the seroconversion rates and the neutralizing antibody levels generated with the Zagreb regimen were higher than those with the Essen regimen when measured 7 days after the first dose.

Keywords: aGV strain*; clinical test*; immunological effect*; rabies vaccine*

0 (Antibodies, Neutralizing)
0 (Antibodies, Viral)
0 (Rabies Vaccines)

Date Created: 20180203 Date Completed: 20180918 Latest Revision: 20180918

20220301

10.1089/vim.2017.0133

29394147