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Evaluation of Analgesic and Anti-Inflammatory Activities of Water Extract of Galla Chinensis In Vivo Models.
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- Author(s): Sun K;Sun K; Song X; Song X; Jia R; Jia R; Yin Z; Yin Z; Zou Y; Zou Y; Li L; Li L; Yin L; Yin L; He C; He C; Liang X; Liang X; Yue G; Yue G; Cui Q; Cui Q; Yang Y; Yang Y
- Source:
Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2018 Feb 18; Vol. 2018, pp. 6784032. Date of Electronic Publication: 2018 Feb 18 (Print Publication: 2018).- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Hindawi Pub Country of Publication: United States NLM ID: 101215021 Publication Model: eCollection Cited Medium: Print ISSN: 1741-427X (Print) Linking ISSN: 1741427X NLM ISO Abbreviation: Evid Based Complement Alternat Med Subsets: PubMed not MEDLINE
- Publication Information: Publication: 2011- : New York, NY : Hindawi Pub.
Original Publication: Oxford, UK : Oxford University Press, c2004- - Abstract: Aim: Pain and inflammation are associated with many diseases in humans and animals. Galla Chinensis , a traditional Chinese medicine, has a variety of pharmacological properties. The purpose of this study was to evaluate analgesic and anti-inflammatory activities of Galla Chinensis through different animal models.
Method: The analgesic activities were evaluated by hot-plate and writhing tests. The anti-inflammatory effects were assessed by ear edema, capillary permeability, and paw edema tests. The contents of cytokines (NO, iNOS, PGE2 , and IL-10) in serum of rats in paw edema test were inspected by ELISA assays.
Results: In the hot-plate test, Galla Chinensis could significantly extend pain threshold when compared to control group. The inhibitory rates of writhes ranged from 36.62% to 68.57% in Galla Chinensis -treated mice. Treatment with Galla Chinensis (1 and 0.5 g/kg) could significantly inhibit ear edema (47.45 and 36.91%, resp.; P < 0.01). Galla Chinensis (1 g/kg) had significant ( P < 0.05) anti-inflammatory activity in capillary permeability test (29.04%). In carrageenan-induced edema test, the inhibitory rates were 43.71% and 44.07% ( P < 0.01) at 1 h and 2 h after administration of Galla Chinensis (1 g/kg), respectively, and the levels of proinflammatory cytokines were significantly reduced.
Conclusion: These results suggest that Galla Chinensis has analgesic and anti-inflammatory effects, which may be a candidate drug for the treatment of inflammation and pain. - References: J Nat Med. 2015 Jul;69(3):324-31. (PMID: 25762161)
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- Publication Date: 20240313
- Accession Number: PMC5835261
- Accession Number: 10.1155/2018/6784032
- Accession Number: 29670660
- Source:
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