A single subcutaneous administration of a sustained-release ivermectin suspension eliminates Psoroptes cuniculi infection in a rabbit farm.

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  • Author(s): Lu M;Lu M;Lu M; Cai Y; Cai Y; Yang S; Yang S; Wan Q; Wan Q; Pan B; Pan B
  • Source:
    Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2018 Dec; Vol. 44 (12), pp. 2000-2004. Date of Electronic Publication: 2018 Sep 19.
  • Publication Type:
    Clinical Trial, Veterinary; Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 7802620 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5762 (Electronic) Linking ISSN: 03639045 NLM ISO Abbreviation: Drug Dev Ind Pharm Subsets: MEDLINE
    • Publication Information:
      Publication: London : Informa Healthcare
      Original Publication: New York, Dekker.
    • Subject Terms:
      Antiparasitic Agents/*administration & dosage ; Ivermectin/*administration & dosage ; Mite Infestations/*drug therapy ; Mite Infestations/*veterinary ; Psoroptidae/*drug effects; Animal Husbandry/methods ; Animals ; China ; Delayed-Action Preparations/administration & dosage ; Ear/parasitology ; Ear/pathology ; Farms ; Female ; Injections, Subcutaneous ; Mite Infestations/parasitology ; Mite Infestations/pathology ; Psoroptidae/pathogenicity ; Rabbits ; Random Allocation ; Skin/parasitology ; Skin/pathology ; Suspensions ; Treatment Outcome
    • Abstract:
      Background: Psoroptes cuniculi mites are the most common ear parasites infesting breeding female rabbits. The suffering rabbits show cutaneous signs of the infestation in the ears and are prone to secondary infections.
      Objectives: This trial was conducted to eliminate P. cuniculi in farm rabbits with a sustained-release ivermectin-loaded solid dispersion suspension (IVM-SD) suspension, and studied the stability of the formulation.
      Animals: There were 986 breeding female Hyplus rabbits naturally infected with P. cuniculi.
      Methods: All rabbits infected with P. cuniculi were subcutaneously administered with a single dose of IVM-SD suspension at 2 mg/kg body weight. Twenty-seven rabbits with severe infections were observed daily and examined on days 0 and 14 to score the lesions and count mites in crusts.
      Results: Fourteen days after the treatment no live mites were detected, demonstrating 100% therapeutic efficacy. The mean lesion scores decreased from 4.33 to 0.11 in the left ears and from 4.22 to 0.22 in the right ears. No reinfection occurred within 60 days of treatment.
      Conclusions: A single subcutaneous administration of the IVM-SD suspension at 2 mg/kg was effective in eliminating P. cuniculi infection in the rabbit farm.
    • Contributed Indexing:
      Keywords: Ivermectin suspension; Psoroptes cuniculi; pharmacodynamics; solid dispersion; subcutaneous
    • Accession Number:
      0 (Antiparasitic Agents)
      0 (Delayed-Action Preparations)
      0 (Suspensions)
      70288-86-7 (Ivermectin)
    • Publication Date:
      Date Created: 20180731 Date Completed: 20190218 Latest Revision: 20190219
    • Publication Date:
      20240104
    • Accession Number:
      10.1080/03639045.2018.1506474
    • Accession Number:
      30058406