Independent association between subjective cognitive decline and frailty in the elderly.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
    • Abstract:
      Background: The relationship between subjective cognitive decline and frailty, two components of the so-called reversible cognitive frailty, in the elderly remains unclear. This study aims to elucidate whether this association exists, independent of confounding factors such as nutritional status, kidney function, inflammation, and insulin resistance.
      Methods: 2386 participants (≥ 65 years of age) selected from the Healthy Aging Longitudinal Study in Taiwan (HALST) study. Fried frailty phenotype was adopted to quantify frailty status. We classified cognitive status into two categories-subjective cognitive decline (SCD), and normal cognition-and used polytomous logistic regressions to investigate the associations between SCD and frailty.
      Results: There were 188 (7.88%), 1228 (51.47%), and 970 (40.65%) participants with frailty, pre-frailty, and robustness, respectively. Compared to those with normal cognition, elders with SCD were more likely to have pre-frailty (odds ratio [OR]: 1.36, 95% confidence interval [CI]: 1.10-1.67, p = 0.004) or frailty (OR: 1.78, 95% CI: 1.23-2.58, p = 0.002) after adjusting for age, gender, education level, comorbidity, nutritional status, kidney function, and biochemical-related factors.
      Conclusions: A significant association between subjective cognitive decline and frailty was revealed in this study. Subjective cognitive decline was positively associated with pre-frailty or frailty even after adjusting for potential confounding factors. Our results can provide useful references in understanding mechanisms and developing suitable preventive strategies for the elderly with reversible cognitive frailty.
      Competing Interests: The authors have declared that no competing interests exist.
    • References:
      Clin Endocrinol (Oxf). 2015 Jun;82(6):844-53. (PMID: 25641226)
      J Am Geriatr Soc. 2010 Feb;58(2):248-55. (PMID: 20070417)
      Neurology. 1999 Jan 1;52(1):78-84. (PMID: 9921852)
      J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56. (PMID: 11253156)
      BMC Geriatr. 2015 Dec 29;15:175. (PMID: 26715536)
      J Nutr Health Aging. 2016 Mar;20(3):288-99. (PMID: 26892578)
      Diabet Med. 2006 May;23(5):469-80. (PMID: 16681555)
      Neuropsychology. 2008 Jul;22(4):531-44. (PMID: 18590364)
      J Nutr Health Aging. 2013 Sep;17(9):726-34. (PMID: 24154642)
      Arch Gen Psychiatry. 2010 Apr;67(4):414-22. (PMID: 20368517)
      J Alzheimers Dis. 2015 Sep 24;48 Suppl 1:S63-86. (PMID: 26402085)
      Alzheimers Dement. 2010 Jan;6(1):11-24. (PMID: 20129317)
      J Nutr Health Aging. 2015 Mar;19(3):276-83. (PMID: 25732212)
      Geriatr Gerontol Int. 2014 Feb;14 Suppl 1:52-60. (PMID: 24450561)
      J Am Geriatr Soc. 2005 Apr;53(4):616-21. (PMID: 15817007)
      J Am Med Dir Assoc. 2017 Jan;18(1):89.e1-89.e8. (PMID: 28012505)
      J Am Geriatr Soc. 1996 Jan;44(1):44-9. (PMID: 8537589)
      Int J Geriatr Psychiatry. 2000 Nov;15(11):983-91. (PMID: 11113976)
      Age (Dordr). 2015 Aug;37(4):9812. (PMID: 26160251)
      Ageing Res Rev. 2013 Sep;12(4):840-51. (PMID: 23831959)
      J Am Geriatr Soc. 2009 Mar;57(3):453-61. (PMID: 19245415)
      Arch Intern Med. 2007 Apr 9;167(7):635-41. (PMID: 17420420)
      Psychol Med. 2007 Dec;37(12):1753-62. (PMID: 17623488)
      Med Sci Sports Exerc. 2011 Aug;43(8):1575-81. (PMID: 21681120)
      J Am Geriatr Soc. 2014 Nov;62(11):2118-24. (PMID: 25370593)
      J Psychiatr Res. 1975 Nov;12(3):189-98. (PMID: 1202204)
      Alzheimers Dement. 2014 Nov;10(6):844-52. (PMID: 24798886)
      Clin J Am Soc Nephrol. 2015 Dec 7;10(12):2181-9. (PMID: 26573615)
      Nutrition. 2000 Jan;16(1):50-63. (PMID: 10674236)
      Int Psychogeriatr. 2014 Jan;26(1):155-63. (PMID: 24153029)
      J Am Med Dir Assoc. 2016 Jan;17(1):36-43. (PMID: 26341037)
      Lancet. 2013 Mar 2;381(9868):752-62. (PMID: 23395245)
      Gerontologist. 1969 Autumn;9(3):179-86. (PMID: 5349366)
      Ageing Res Rev. 2015 Mar;20:1-10. (PMID: 25555677)
      Expert Opin Drug Metab Toxicol. 2017 Oct;13(10):1023-1027. (PMID: 28849681)
      J Am Med Dir Assoc. 2013 Jul;14(7):518-24. (PMID: 23669054)
      Int J Epidemiol. 2017 Aug 1;46(4):1106-1106j. (PMID: 28369534)
      J Gerontol A Biol Sci Med Sci. 2010 Nov;65(11):1228-34. (PMID: 20622137)
      J Am Med Dir Assoc. 2017 Mar 1;18(3):252-258. (PMID: 27838339)
      Am J Med. 2009 Jul;122(7):664-71.e2. (PMID: 19559169)
      J Nutr Health Aging. 2011 Dec;15(10):852-6. (PMID: 22159772)
      J Am Med Dir Assoc. 2015 Feb;16(2):120-4. (PMID: 25244957)
      Clin Nutr. 2016 Feb;35(1):138-43. (PMID: 25649256)
      Psychosom Med. 2007 Jun;69(5):483-9. (PMID: 17556640)
      Diabetologia. 1985 Jul;28(7):412-9. (PMID: 3899825)
    • Publication Date:
      Date Created: 20180803 Date Completed: 20190123 Latest Revision: 20190123
    • Publication Date:
      20240104
    • Accession Number:
      PMC6072005
    • Accession Number:
      10.1371/journal.pone.0201351
    • Accession Number:
      30071051