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Independent association between subjective cognitive decline and frailty in the elderly.
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- Author(s): Hsieh TJ;Hsieh TJ; Chang HY; Chang HY; Wu IC; Wu IC; Chen CC; Chen CC; Tsai HJ; Tsai HJ; Chiu YF; Chiu YF; Chuang SC; Chuang SC; Hsiung CA; Hsiung CA; Hsu CC; Hsu CC; Hsu CC; Hsu CC
- Source:
PloS one [PLoS One] 2018 Aug 02; Vol. 13 (8), pp. e0201351. Date of Electronic Publication: 2018 Aug 02 (Print Publication: 2018).- Publication Type:
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
- Publication Information: Original Publication: San Francisco, CA : Public Library of Science
- Subject Terms:
- Abstract: Background: The relationship between subjective cognitive decline and frailty, two components of the so-called reversible cognitive frailty, in the elderly remains unclear. This study aims to elucidate whether this association exists, independent of confounding factors such as nutritional status, kidney function, inflammation, and insulin resistance.
Methods: 2386 participants (≥ 65 years of age) selected from the Healthy Aging Longitudinal Study in Taiwan (HALST) study. Fried frailty phenotype was adopted to quantify frailty status. We classified cognitive status into two categories-subjective cognitive decline (SCD), and normal cognition-and used polytomous logistic regressions to investigate the associations between SCD and frailty.
Results: There were 188 (7.88%), 1228 (51.47%), and 970 (40.65%) participants with frailty, pre-frailty, and robustness, respectively. Compared to those with normal cognition, elders with SCD were more likely to have pre-frailty (odds ratio [OR]: 1.36, 95% confidence interval [CI]: 1.10-1.67, p = 0.004) or frailty (OR: 1.78, 95% CI: 1.23-2.58, p = 0.002) after adjusting for age, gender, education level, comorbidity, nutritional status, kidney function, and biochemical-related factors.
Conclusions: A significant association between subjective cognitive decline and frailty was revealed in this study. Subjective cognitive decline was positively associated with pre-frailty or frailty even after adjusting for potential confounding factors. Our results can provide useful references in understanding mechanisms and developing suitable preventive strategies for the elderly with reversible cognitive frailty.
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- Publication Date: 20240104
- Accession Number: PMC6072005
- Accession Number: 10.1371/journal.pone.0201351
- Accession Number: 30071051
- Source:
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