The significance of thrombophilia in paediatric thromboembolism.

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  • Author(s): Hedegaard SS;Hedegaard SS; Klein AC; Klein AC; Hvas AM; Hvas AM; Hvas AM
  • Source:
    Scandinavian journal of clinical and laboratory investigation [Scand J Clin Lab Invest] 2018 Nov - Dec; Vol. 78 (7-8), pp. 551-555. Date of Electronic Publication: 2018 Sep 27.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 0404375 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1502-7686 (Electronic) Linking ISSN: 00365513 NLM ISO Abbreviation: Scand J Clin Lab Invest Subsets: MEDLINE
    • Publication Information:
      Publication: London : Informa Healthcare
      Original Publication: Oslo, Medisinsk Fysiologisk Forenings Forlag.
    • Subject Terms:
    • Abstract:
      The role of thrombophilia in paediatric thromboembolic disease remains controversial. The objective of the present study was to investigate the prevalence of thrombophilia and other risk factors among children with a thromboembolic event. We systematically examined the medical records and laboratory results of 126 children (≤15 years) referred to Aarhus University Hospital, Denmark with a recent thromboembolic event during 2005-2016. Among the 126 children with thrombosis, 99 (79%) had arterial thrombosis, 66 (52%) being in the neonatal period. Remarkably, 48 (38%) children had occurrence of acute illness or underlying disease prior to the thromboembolic event. In total, 11 (11%) children with arterial thrombosis had a hereditary or acquired thrombophilia with a non-significant odds ratio compared with the general population, while 9 of the 27 (33%) children with venous thrombosis had a hereditary or acquired thrombophilia being significantly higher than in the general population. Acute illness or underlying diseases seem to induce increased risk of thromboembolic disease in children. The present study does not support that thrombophilia is associated with arterial thrombosis. However, the results support thrombophilia testing in children with venous thromboembolism.
    • Contributed Indexing:
      Keywords: Child; infant; newborn; stroke; thromboembolism; thrombophilia
    • Publication Date:
      Date Created: 20180929 Date Completed: 20190423 Latest Revision: 20190423
    • Publication Date:
      20240105
    • Accession Number:
      10.1080/00365513.2018.1517418
    • Accession Number:
      30261760