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Predicting tubal factor infertility by using markers of humoral and cell-mediated immune response against Chlamydia trachomatis.
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- Author(s): Rantsi T;Rantsi T; Öhman H; Öhman H; Öhman H; Puolakkainen M; Puolakkainen M; Bloigu A; Bloigu A; Paavonen J; Paavonen J; Surcel HM; Surcel HM; Surcel HM; Surcel HM; Tiitinen A; Tiitinen A; Joki-Korpela P; Joki-Korpela P
- Source:
American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2018 Nov; Vol. 80 (5), pp. e13051. Date of Electronic Publication: 2018 Oct 03.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 8912860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0897 (Electronic) Linking ISSN: 10467408 NLM ISO Abbreviation: Am J Reprod Immunol Subsets: MEDLINE
- Publication Information: Publication: Copenhagen : Wiley-Blackwell
Original Publication: New York : Alan R. Liss, Inc., c1989- - Subject Terms: Immunity, Humoral*; Chlamydia Infections/*immunology ; Chlamydia trachomatis/*physiology ; Fallopian Tubes/*pathology ; Infertility, Female/*immunology ; Lymphocytes/*immunology; Adult ; Antibodies, Bacterial/blood ; Biomarkers/blood ; Cell Proliferation ; Cells, Cultured ; Chaperonin 60/immunology ; Chlamydia Infections/diagnosis ; Female ; Humans ; Immunity, Cellular ; Infertility, Female/diagnosis ; Porins/immunology ; Predictive Value of Tests ; Pregnancy ; Prognosis ; Prospective Studies ; Sensitivity and Specificity
- Abstract: Problem: The accuracy of Chlamydia trachomatis antibody test in predicting tubal factor infertility (TFI) is limited, and more accurate methods are needed. Cell-mediated immune response (CMI) is crucial in the resolution of pathogen, but it may play an important role in the pathogenesis of C trachomatis-associated tubal damage. We studied whether combining the markers of C trachomatis-induced CMI to humoral immune response improves the accuracy of serology in TFI prediction.
Method of Study: Our prospective study consists of 258 subfertile women, of whom 22 (8.5%) had TFI. Women with other causes for subfertility served as a reference group. Serum C trachomatis major outer membrane protein (MOMP) and chlamydial heat-shock protein 60 (cHSP60) IgG antibodies were measured by ELISA. CMI was studied by lymphocyte proliferation assay in vitro.
Results: Serological markers were more prevalent in women with TFI than in other subfertile women (40.9% vs 12.3% for MOMP IgG and 27.3% vs 10.2% for cHSP60 IgG). The best test combination for TFI was C. trachomatis MOMP and cHSP60 antibody with an accuracy of 90.3%, sensitivity of 22.7% and specificity of 96.6%. Positive post-test probability of this combination was 54.2%, and negative post-test probability was 12.4%. Adding of the markers of CMI did not significantly improve the accuracy of serology in TFI prediction.
Conclusion: The accuracy of TFI prediction increases when the combination of C trachomatis MOMP and cHSP60 antibody tests is used. C trachomatis-induced CMI was common in our study population, but the markers of CMI did not predict TFI.
(© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) - Grant Information: International Helsingin ja Uudenmaan Sairaanhoitopiiri; International Suomen Akatemia; International Päivikki ja Sakari Sohlbergin Säätiö; International Paulo Foundation
- Contributed Indexing: Keywords: Chlamydia trachomatis; cell-mediated immune response; diagnostic test; serology; tubal evaluation; tubal factor infertility
- Accession Number: 0 (Antibodies, Bacterial)
0 (Biomarkers)
0 (Chaperonin 60)
0 (Porins)
146409-23-6 (omp1 protein, Chlamydia trachomatis) - Publication Date: Date Created: 20181004 Date Completed: 20191028 Latest Revision: 20191028
- Publication Date: 20240105
- Accession Number: 10.1111/aji.13051
- Accession Number: 30281189
- Source:
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