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Application of polycaprolactone, chitosan, and collagen composite as a nanofibrous mat loaded with silver sulfadiazine and growth factors for wound dressing.
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- Author(s): Nejaddehbashi F;Nejaddehbashi F; Hashemitabar M; Hashemitabar M; Bayati V; Bayati V; Abbaspour M; Abbaspour M; Moghimipour E; Moghimipour E; Moghimipour E; Orazizadeh M; Orazizadeh M
- Source:
Artificial organs [Artif Organs] 2019 Apr; Vol. 43 (4), pp. 413-423. Date of Electronic Publication: 2018 Nov 22.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 7802778 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-1594 (Electronic) Linking ISSN: 0160564X NLM ISO Abbreviation: Artif Organs
- Publication Information: Publication: Cambridge, MA : Wiley-Blackwell
Original Publication: Cleveland, International Society for Artificial Organs. - Subject Terms: Bandages*; Anti-Infective Agents, Local/*administration & dosage ; Chitosan/*chemistry ; Collagen/*chemistry ; Intercellular Signaling Peptides and Proteins/*administration & dosage ; Polyesters/*chemistry ; Silver Sulfadiazine/*administration & dosage ; Wound Healing/*drug effects; Animals ; Anti-Infective Agents, Local/therapeutic use ; Biocompatible Materials/chemistry ; Epidermal Growth Factor/administration & dosage ; Epidermal Growth Factor/therapeutic use ; Fibroblast Growth Factor 2/administration & dosage ; Fibroblast Growth Factor 2/therapeutic use ; Intercellular Signaling Peptides and Proteins/therapeutic use ; Male ; Nanofibers/chemistry ; Nanofibers/ultrastructure ; Rats ; Rats, Sprague-Dawley ; Silver Sulfadiazine/therapeutic use
- Abstract: Fabrication of nanofibrous biomaterials composed of natural and synthetic materials that incorporated with antibiotic and growth factors with controlled release manner is an attractive topic in wound healing. The purpose of this study was to prepare optimal composite of materials as biomimetic nanofibrous mats for application in wound healing. The mat was prepared of polycaprolactone (PCL) in the bottom, chitosan/poly ethylene oxide (Cs/PEO) in the middle, and PCL/collagen (PCL/Coll) in the top layer. A panel of standard characterization tests of nanofibrous mat was performed and its compatibilities in strength and integration were confirmed. Middle layer was loaded with epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF), and silver sulfadiazine (SSD) was incorporated in the bottom layer as an anti-infection factor. Then, on the dorsum of rats, a 400-mm 2 wound was created and surrounded by a silicone ring to control the usual tissue contractions. Nanofibrous mats with or without growth factors were applied as wound dressings and at day 14, the healing process was evaluated. At day 14, the treated group by designed mat showed faster epithelialization and angiogenesis. Silicone ring in the test group was desirable in wound closure compared to the control group. Reformation of skin tissue was manifested in a shorter time. This composite nanofibrous mat could be introduced as a dynamic and effective candidate for wound dressing.
(© 2018 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.) - Grant Information: CMRC-9427 Ahvaz Jundishapur University of Medical Sciences, Cellular and Molecular Research Center
- Contributed Indexing: Keywords: active wound dressing; electrospinning; growth factors; scaffold; three-dimensional mat; wound healing
- Accession Number: 0 (Anti-Infective Agents, Local)
0 (Biocompatible Materials)
0 (Intercellular Signaling Peptides and Proteins)
0 (Polyesters)
103107-01-3 (Fibroblast Growth Factor 2)
24980-41-4 (polycaprolactone)
62229-50-9 (Epidermal Growth Factor)
9007-34-5 (Collagen)
9012-76-4 (Chitosan)
W46JY43EJR (Silver Sulfadiazine) - Publication Date: Date Created: 20181013 Date Completed: 20190805 Latest Revision: 20190805
- Publication Date: 20240104
- Accession Number: 10.1111/aor.13369
- Accession Number: 30311249
- Source:
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