Estimates of the Global Burden of Ambient [Formula: see text], Ozone, and [Formula: see text] on Asthma Incidence and Emergency Room Visits.

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  • Additional Information
    • Source:
      Publisher: National Institute of Environmental Health Sciences Country of Publication: United States NLM ID: 0330411 Publication Model: Print Cited Medium: Internet ISSN: 1552-9924 (Electronic) Linking ISSN: 00916765 NLM ISO Abbreviation: Environ Health Perspect Subsets: MEDLINE
    • Publication Information:
      Original Publication: Research Triangle Park, N. C. National Institute of Environmental Health Sciences.
    • Subject Terms:
      Air Pollution/*adverse effects ; Asthma/*epidemiology ; Nitrogen Dioxide/*adverse effects ; Ozone/*adverse effects ; Particulate Matter/*adverse effects; Emergency Service, Hospital/statistics & numerical data ; Environmental Exposure/adverse effects ; Humans ; Incidence ; Ozone/chemistry ; Particle Size ; Risk Factors
    • Abstract:
      Background: Asthma is the most prevalent chronic respiratory disease worldwide, affecting 358 million people in 2015. Ambient air pollution exacerbates asthma among populations around the world and may also contribute to new-onset asthma.
      Objectives: We aimed to estimate the number of asthma emergency room visits and new onset asthma cases globally attributable to fine particulate matter ([Formula: see text]), ozone, and nitrogen dioxide ([Formula: see text]) concentrations.
      Methods: We used epidemiological health impact functions combined with data describing population, baseline asthma incidence and prevalence, and pollutant concentrations. We constructed a new dataset of national and regional emergency room visit rates among people with asthma using published survey data.
      Results: We estimated that 9–23 million and 5–10 million annual asthma emergency room visits globally in 2015 could be attributable to ozone and [Formula: see text], respectively, representing 8–20% and 4–9% of the annual number of global visits, respectively. The range reflects the application of central risk estimates from different epidemiological meta-analyses. Anthropogenic emissions were responsible for [Formula: see text] and 73% of ozone and [Formula: see text] impacts, respectively. Remaining impacts were attributable to naturally occurring ozone precursor emissions (e.g., from vegetation, lightning) and [Formula: see text] (e.g., dust, sea salt), though several of these sources are also influenced by humans. The largest impacts were estimated in China and India.
      Conclusions: These findings estimate the magnitude of the global asthma burden that could be avoided by reducing ambient air pollution. We also identified key uncertainties and data limitations to be addressed to enable refined estimation. https://doi.org/10.1289/EHP3766.
    • Comments:
      Comment in: Environ Health Perspect. 2019 Jul;127(7):74001. (PMID: 31313937)
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    • Accession Number:
      0 (Particulate Matter)
      66H7ZZK23N (Ozone)
      S7G510RUBH (Nitrogen Dioxide)
    • Publication Date:
      Date Created: 20181106 Date Completed: 20190408 Latest Revision: 20231229
    • Publication Date:
      20231229
    • Accession Number:
      PMC6371661
    • Accession Number:
      10.1289/EHP3766
    • Accession Number:
      30392403