Asymmetric Insular Connectomics Revealed by Diffusion Magnetic Resonance Imaging Analysis of Healthy Brain Development.

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  • Additional Information
    • Source:
      Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101550313 Publication Model: Print Cited Medium: Internet ISSN: 2158-0022 (Electronic) Linking ISSN: 21580014 NLM ISO Abbreviation: Brain Connect Subsets: MEDLINE
    • Publication Information:
      Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc.
    • Subject Terms:
    • Abstract:
      The insula has been implicated in playing important roles in various brain functions including consciousness, homeostasis, perception, self-awareness, language processing, and interpersonal experience. Abnormalities of the insula have been observed in patients suffering from addiction, deteriorating language function, anorexia, and emotional dysregulation. We analyzed typical development of insular connections in a large-scale pediatric population using 642 magnetic resonance imaging examinations. Interpreting large quantities of acquired data is one of the major challenges in connectomics. This article focuses its analysis on the connectivity observed between the insula and many other regions throughout the brain and performs a hemispheric asymmetry analysis comparing localized connectome measurements. Results demonstrate asymmetries in the pathways connecting the insula to the superior temporal region, pars opercularis, etc. that may be representative of language lateralization in the brain. Results also demonstrate multiple fiber pathways that exhibit hemispheric dominance in tract length and an inverted hemispheric dominance in tract counts, implying the presence of asymmetric lateralization of some of the brain's insular pathways. This study illustrates the investigative potential of performing connectomics-style analyses in a clinical context across a large population of children as part of routine imaging, demonstrating the feasibility of using current technologies to perform regionally focused clinical connectivity studies.
    • References:
      Front Neurosci. 2017 Jul 11;11:348. (PMID: 28744187)
      Neuroimage. 2002 Mar;15(3):596-603. (PMID: 11848702)
      Schizophr Res. 2008 Dec;106(2-3):115-24. (PMID: 18804959)
      Neuroimage. 2010 Apr 1;50(2):709-16. (PMID: 20045470)
      PLoS One. 2012;7(4):e35589. (PMID: 22536413)
      Sci Rep. 2015 Mar 11;5:8933. (PMID: 25757374)
      Med Image Anal. 2001 Jun;5(2):143-56. (PMID: 11516708)
      Nat Neurosci. 2010 Nov;13(11):1428-32. (PMID: 20890293)
      Cereb Cortex. 2007 May;17(5):1139-46. (PMID: 16855007)
      PLoS One. 2014 Nov 18;9(11):e112842. (PMID: 25405994)
      J Pain. 2013 Oct;14(10):1217-26. (PMID: 23871603)
      Dev Neuropsychol. 2007;31(2):217-38. (PMID: 17488217)
      Brain Lang. 2014 Aug;135:96-103. (PMID: 25016092)
      Neuroimage. 2004 Nov;23(3):1176-85. (PMID: 15528117)
      Brain Struct Funct. 2017 Dec;222(9):3991-4004. (PMID: 28585051)
      Neuroimage. 2014 May 1;91:177-86. (PMID: 24440528)
      Neuron. 2003 Oct 30;40(3):655-64. (PMID: 14642287)
      Brain Topogr. 2012 Jul;25(3):264-71. (PMID: 22002490)
      J Alzheimers Dis. 2009;17(3):571-83. (PMID: 19433891)
      Front Neurosci. 2017 Jul 14;11:389. (PMID: 28769741)
      Neuron. 2003 Dec 4;40(5):885-95. (PMID: 14659088)
      Multimodal Brain Image Anal (2011). 2011;2011:35-43. (PMID: 25346947)
      Cereb Cortex. 2018 Oct 1;28(10):3555-3563. (PMID: 28968767)
      Hum Brain Mapp. 2014 May;35(5):2320-32. (PMID: 23861356)
      J Comp Neurol. 1989 Apr 8;282(2):293-316. (PMID: 2708598)
      Nat Neurosci. 2004 Feb;7(2):189-95. (PMID: 14730305)
      Neuroimage. 2009 Oct 1;47(4):1992-2004. (PMID: 19497376)
      NMR Biomed. 2012 Nov;25(11):1224-33. (PMID: 22438202)
      Brain Struct Funct. 2010 Jun;214(5-6):519-34. (PMID: 20512376)
      Brain Lang. 1998 Oct 1;64(3):282-96. (PMID: 9743543)
      Hum Brain Mapp. 2017 Dec;38(12):5931-5942. (PMID: 28898497)
      Nat Neurosci. 2000 Feb;3(2):184-90. (PMID: 10649575)
      Cereb Cortex. 2001 Sep;11(9):868-77. (PMID: 11532891)
      Front Psychiatry. 2014 Jan 09;4:186. (PMID: 24409158)
      Science. 2003 Jun 13;300(5626):1755-8. (PMID: 12805551)
      Dev Neurosci. 2015;37(2):182-94. (PMID: 25791575)
      Neuroimage. 2008 Feb 15;39(4):1877-85. (PMID: 18083565)
      Brain Lang. 2013 Aug;126(2):109-22. (PMID: 23681069)
      Arch Neurol. 1977 Jun;34(6):346-8. (PMID: 860936)
      AJNR Am J Neuroradiol. 2013 Jul;34(7):1443-9. (PMID: 23370472)
      Magn Reson Med. 2002 Jun;47(6):1083-99. (PMID: 12111955)
      Biomed Res Int. 2014;2014:860658. (PMID: 24724105)
      Science. 2002 Nov 8;298(5596):1191-4. (PMID: 12424363)
      Neuroimage Clin. 2014 Feb 19;4:604-14. (PMID: 24936411)
      Nat Rev Neurosci. 2009 Jan;10(1):59-70. (PMID: 19096369)
      Int J Dev Neurosci. 2016 May;50:26-38. (PMID: 26948153)
      Neuroimage. 2002 Oct;17(2):825-41. (PMID: 12377157)
      Hum Brain Mapp. 2005 Jun;25(2):259-65. (PMID: 15849712)
      BMC Psychiatry. 2012 May 20;12:45. (PMID: 22607202)
      Cereb Cortex. 2003 Feb;13(2):170-7. (PMID: 12507948)
      Sci Rep. 2015 Dec 22;5:18883. (PMID: 26689815)
      Conscious Cogn. 2003 Dec;12(4):717-31. (PMID: 14656513)
      Brain Res. 2014 Nov 7;1588:73-80. (PMID: 25239477)
      Psychiatry Res. 2012 Oct 30;204(1):32-9. (PMID: 23142193)
      Hum Brain Mapp. 2003 Oct;20(2):82-90. (PMID: 14505334)
      NMR Biomed. 2013 Dec;26(12):1775-86. (PMID: 24038308)
      Cereb Cortex. 2012 Feb;22(2):455-64. (PMID: 21670100)
      Amyotroph Lateral Scler Frontotemporal Degener. 2013 Dec;14(7-8):553-61. (PMID: 23586325)
      J Neurosurg. 1999 Apr;90(4):720-33. (PMID: 10193618)
      Hum Brain Mapp. 2009 Oct;30(10):3172-87. (PMID: 19241418)
      Biol Mood Anxiety Disord. 2011 Sep 27;1(1):3. (PMID: 22738088)
      Neuroimage. 2007 May 1;35(4):1459-72. (PMID: 17379540)
      Eur J Neurosci. 2015 May;41(11):1438-47. (PMID: 25858359)
      Brain Res Brain Res Rev. 2003 May;42(2):143-54. (PMID: 12738055)
      Nature. 1996 Nov 14;384(6605):159-61. (PMID: 8906789)
      J Neurosci. 1997 Dec 15;17(24):9686-705. (PMID: 9391023)
      Trends Neurosci. 2017 Apr;40(4):200-207. (PMID: 28314446)
      Brain Res Brain Res Rev. 1996 Oct;22(3):229-44. (PMID: 8957561)
      J Hum Evol. 2013 Apr;64(4):263-79. (PMID: 23466178)
      Nat Rev Neurosci. 2002 Aug;3(8):655-66. (PMID: 12154366)
      Neuroimage. 2012 Aug 15;62(2):774-81. (PMID: 22248573)
      J Comp Neurol. 1986 Oct 15;252(3):323-47. (PMID: 3793980)
      Brain. 2014 Aug;137(Pt 8):2143-54. (PMID: 24736308)
      Biol Psychiatry. 2007 Apr 15;61(8):1007-10. (PMID: 17123478)
    • Grant Information:
      R01 HD078561 United States HD NICHD NIH HHS; R03 NS091587 United States NS NINDS NIH HHS; R21 MH118739 United States MH NIMH NIH HHS
    • Contributed Indexing:
      Keywords: asymmetry; connectomics; diffusion; healthy development; insula; magnetic resonance imaging
    • Publication Date:
      Date Created: 20181204 Date Completed: 20190829 Latest Revision: 20200309
    • Publication Date:
      20240105
    • Accession Number:
      PMC6390666
    • Accession Number:
      10.1089/brain.2018.0582
    • Accession Number:
      30501515