Global, Survival, and Apoptotic Transcriptome during Mouse and Human Early Embryonic Development.

Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE

Original Publication: New York, NY : Hindawi Pub. Co.

Apoptosis/*genetics ; Caspases/*genetics ; Embryonic Development/*genetics ; Transcriptome/*genetics; Animals ; Apoptosis Inducing Factor/genetics ; Blastocyst/metabolism ; Embryo, Mammalian ; Gene Expression Regulation, Developmental ; Genome/genetics ; Humans ; Mice ; Oligonucleotide Array Sequence Analysis ; Oocytes/growth & development ; Oocytes/metabolism ; Signal Transduction/genetics

Survival and cell death signals are crucial for mammalian embryo preimplantation development. However, the knowledge on the molecular mechanisms underlying their regulation is still limited. Mouse studies are widely used to understand preimplantation embryo development, but extrapolation of these results to humans is questionable. Therefore, we wanted to analyse the global expression profiles during early mouse and human development with a special focus on genes involved in the regulation of the apoptotic and survival pathways. We used DNA microarray technology to analyse the global gene expression profiles of preimplantation human and mouse embryos (metaphase II oocytes, embryos at the embryonic genome activation stage, and blastocysts). Components of the major apoptotic and survival signalling pathways were expressed during early human and mouse embryonic development; however, most expression profiles were species-specific. Particularly, the expression of genes encoding components and regulators of the apoptotic machinery were extremely stable in mouse embryos at all analysed stages, while it was more stage-specific in human embryos. CASP3 , CASP9 , and AIF were the only apoptosis-related genes expressed in both species and at all studied stages. Moreover, numerous transcripts related to the apoptotic and survival pathway were reported for the first time such as CASP6 and IL1RAPL1 that were specific to MII oocytes; CASP2 , ENDOG , and GFER to blastocysts in human. These findings open new perspectives for the characterization and understanding of the survival and apoptotic signalling pathways that control early human and mouse embryonic development.

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0 (AIFM1 protein, human)
0 (Apoptosis Inducing Factor)
EC 3.4.22.- (Caspases)

Date Created: 20181206 Date Completed: 20190319 Latest Revision: 20190319

20240105

PMC6236930

10.1155/2018/5895628

30515407