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Apoptosis in patients with primary antiphospholipid antibody syndrome.
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- Author(s): Tang KT;Tang KT; Hsieh TY; Hsieh TY; Chao YH; Chao YH; Li JP; Li JP; Li JP; Lan JL; Lan JL; Lan JL; Lan JL; Lin CC; Lin CC; Lin CC; Chen DY; Chen DY; Chen DY; Chen DY
- Source:
International journal of rheumatic diseases [Int J Rheum Dis] 2019 Apr; Vol. 22 (4), pp. 677-685. Date of Electronic Publication: 2019 Feb 06.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Wiley on behalf of the Asia Pacific League of Associations for Rheumatology Country of Publication: England NLM ID: 101474930 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-185X (Electronic) Linking ISSN: 17561841 NLM ISO Abbreviation: Int J Rheum Dis Subsets: MEDLINE
- Publication Information: Original Publication: [Oxford, UK] : Wiley on behalf of the Asia Pacific League of Associations for Rheumatology
- Subject Terms: Apoptosis*; Antiphospholipid Syndrome/*pathology ; Apoptosis Regulatory Proteins/*blood ; Cytokines/*blood ; Lymphocytes/*pathology ; Monocytes/*pathology; Adult ; Antiphospholipid Syndrome/blood ; Antiphospholipid Syndrome/genetics ; Antiphospholipid Syndrome/immunology ; Apoptosis Regulatory Proteins/genetics ; Biomarkers/blood ; Case-Control Studies ; Female ; Humans ; Interleukin-10/blood ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Male ; Middle Aged ; Monocytes/immunology ; Monocytes/metabolism ; Prospective Studies ; TNF-Related Apoptosis-Inducing Ligand/blood ; Tumor Necrosis Factor-alpha/blood
- Abstract: Aim: Dysregulated apoptosis has been implicated in autoimmune diseases. In the present study, we investigated the apoptosis-related cytokines and apoptosis in patients with primary antiphospholipid syndrome (pAPS).
Method: We prospectively recruited 12 pAPS patients, 17 antiphospholipid antibody (APA)-positive systemic lupus erythematosus (SLE) patients without APS manifestations (APA + SLE), 13 SLE patients with secondary APS (APS + SLE) and 10 healthy controls (HCs). Plasma levels of soluble apoptosis-inducing ligands and cytokines, and the expression levels of apoptosis-inducing ligands in peripheral blood mononuclear cells, were determined. In addition, blood lymphocytes/monocytes apoptosis were determined in six pAPS patients and six HCs, using flow cytometric analysis of caspase 3, 8 and 9 activities.
Results: There was a trend toward higher plasma levels of soluble tumor necrosis factor (TNF)-related apoptosis-inducing ligand (sTRAIL), interleukin-10 (IL-10) and TNF-α in pAPS patients when compared with HCs. We also observed higher plasma levels of IL-10 and TNF α in APA + SLE and APS + SLE patients when compared with HCs. However, there was no significant difference in blood lymphocytes/monocytes apoptosis between pAPS patients and HCs.
Conclusion: There was a trend toward elevated plasma levels of sTRAIL, IL-10 and TNF-α, but no evidence for dysregulated apoptosis in pAPS patients.
(© 2019 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.) - Grant Information: TCVGH-NCHU1057611 Taichung Veterans General Hospital and National Chung Hsing University
- Contributed Indexing: Keywords: Fas ligand; antiphospholipid antibody syndrome; apoptosis; caspase; systemic lupus erythematosus; tumor necrosis factor-like weak inducer of apoptosis; tumor necrosis factor-related apoptosis-inducing ligand
- Accession Number: 0 (Apoptosis Regulatory Proteins)
0 (Biomarkers)
0 (Cytokines)
0 (IL10 protein, human)
0 (TNF-Related Apoptosis-Inducing Ligand)
0 (TNFSF10 protein, human)
0 (Tumor Necrosis Factor-alpha)
130068-27-8 (Interleukin-10) - Publication Date: Date Created: 20190208 Date Completed: 20190903 Latest Revision: 20190903
- Publication Date: 20240105
- Accession Number: 10.1111/1756-185X.13468
- Accession Number: 30729698
- Source:
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