The impact of SLE on health-related quality of life assessed with SF-36: a systemic review and meta-analysis.

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  • Additional Information
    • Source:
      Publisher: SAGE Publications Country of Publication: England NLM ID: 9204265 Publication Model: Print Cited Medium: Internet ISSN: 1477-0962 (Electronic) Linking ISSN: 09612033 NLM ISO Abbreviation: Lupus Subsets: MEDLINE
    • Publication Information:
      Publication: London : SAGE Publications
      Original Publication: Houndmills, Basingstoke, Hampshire, UK : Scientific & Medical Division, Macmillan Press Ltd., c1991-
    • Subject Terms:
      Quality of Life* ; Surveys and Questionnaires*; Lupus Erythematosus, Systemic/*psychology; Case-Control Studies ; Cross-Sectional Studies ; Female ; Humans ; Longitudinal Studies ; Male ; Severity of Illness Index
    • Abstract:
      Objective: To evaluate the impact of systemic lupus erythematosus (SLE) on health-related quality of life (HRQoL) assessed with SF-36 and explore factors associated with HRQoL in SLE patients.
      Methods: A random-effect meta-analysis was performed to calculate extracted data. Sensitivity and subgroup analyses were performed to distinguish sources of heterogeneity.
      Results: A total of 36 articles were finally included in this meta-analysis, including 6510 patients. The pooled mean scores of SF-36 physical component summary and mental component summary were 46.10 (95% confidence interval (CI): 43.09-49.10) and 50.37 (95% CI: 47.78-52.87), respectively. Spearman's correlation analysis found that mean age, proportion of female participants, and publication decades were negatively associated with some of the SF-36 domains. Sample size and SLEDAI were positively associated with some of the SF-36 domains. Patients with SLE have lower HRQoL in comparison to the general population.
      Conclusions: SLE has a significant impact on HRQoL, which proves that the necessity of improving HRQoL in SLE patients cannot be ignored. Measuring HRQoL should be considered as an indispensable part of the overall evaluation of health conditions of SLE patients.
    • Contributed Indexing:
      Keywords: Meta-analysis; SF-36; health-related quality of life; systemic lupus erythematosus
    • Publication Date:
      Date Created: 20190301 Date Completed: 20190715 Latest Revision: 20190715
    • Publication Date:
      20240105
    • Accession Number:
      10.1177/0961203319828519
    • Accession Number:
      30813871