Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensis.

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  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
    • Abstract:
      Diffuse cutaneous leishmaniasis (DCL) is a rare form of leishmaniasis where parasites grow uncontrolled in diffuse lesions across the skin. Meta-transcriptomic analysis of biopsies from DCL patients infected with Leishmania amazonensis demonstrated an infiltration of atypical B cells producing a surprising preponderance of the IgG4 isotype. DCL lesions contained minimal CD8+ T cell transcripts and no evidence of persistent TH2 responses. Whereas localized disease exhibited activated (so-called M1) macrophage presence, transcripts in DCL suggested a regulatory macrophage (R-Mϕ) phenotype with higher levels of ABCB5, DCSTAMP, SPP1, SLAMF9, PPARG, MMPs, and TM4SF19. The high levels of parasite transcripts in DCL and the remarkable uniformity among patients afforded a unique opportunity to study parasite gene expression in this disease. Patterns of parasite gene expression in DCL more closely resembled in vitro parasite growth in resting macrophages, in the absence of T cells. In contrast, parasite gene expression in LCL revealed 336 parasite genes that were differently upregulated, relative to DCL and in vitro macrophage growth, and these transcripts may represent transcripts that are produced by the parasite in response to host immune pressure.
    • Accession Number:
      0 (Antigens, Protozoan)
      0 (Immunoglobulin G)
    • Publication Date:
      Date Created: 20190308 Date Completed: 20190425 Latest Revision: 20190425
    • Publication Date:
      20190426
    • Accession Number:
      10.1371/journal.pntd.0007152
    • Accession Number:
      30845223
  • Citations
    • ABNT:
      CHRISTENSEN, S. M. et al. Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensis. Plos Neglected Tropical Diseases, [s. l.], v. 13, n. 3, p. e0007152, 2019. DOI 10.1371/journal.pntd.0007152. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=30845223. Acesso em: 11 dez. 2019.
    • AMA:
      Christensen SM, Belew AT, El-Sayed NM, Tafuri WL, Silveira FT, Mosser DM. Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensis. Plos Neglected Tropical Diseases. 2019;13(3):e0007152. doi:10.1371/journal.pntd.0007152.
    • APA:
      Christensen, S. M., Belew, A. T., El-Sayed, N. M., Tafuri, W. L., Silveira, F. T., & Mosser, D. M. (2019). Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensis. Plos Neglected Tropical Diseases, 13(3), e0007152. https://doi.org/10.1371/journal.pntd.0007152
    • Chicago/Turabian: Author-Date:
      Christensen, Stephen M, Ashton T Belew, Najib M El-Sayed, Wagner L Tafuri, Fernando T Silveira, and David M Mosser. 2019. “Host and Parasite Responses in Human Diffuse Cutaneous Leishmaniasis Caused by L. Amazonensis.” Plos Neglected Tropical Diseases 13 (3): e0007152. doi:10.1371/journal.pntd.0007152.
    • Harvard:
      Christensen, S. M. et al. (2019) ‘Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensis’, Plos Neglected Tropical Diseases, 13(3), p. e0007152. doi: 10.1371/journal.pntd.0007152.
    • Harvard: Australian:
      Christensen, SM, Belew, AT, El-Sayed, NM, Tafuri, WL, Silveira, FT & Mosser, DM 2019, ‘Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensis’, Plos Neglected Tropical Diseases, vol. 13, no. 3, p. e0007152, viewed 11 December 2019, .
    • MLA:
      Christensen, Stephen M., et al. “Host and Parasite Responses in Human Diffuse Cutaneous Leishmaniasis Caused by L. Amazonensis.” Plos Neglected Tropical Diseases, vol. 13, no. 3, Mar. 2019, p. e0007152. EBSCOhost, doi:10.1371/journal.pntd.0007152.
    • Chicago/Turabian: Humanities:
      Christensen, Stephen M, Ashton T Belew, Najib M El-Sayed, Wagner L Tafuri, Fernando T Silveira, and David M Mosser. “Host and Parasite Responses in Human Diffuse Cutaneous Leishmaniasis Caused by L. Amazonensis.” Plos Neglected Tropical Diseases 13, no. 3 (March 7, 2019): e0007152. doi:10.1371/journal.pntd.0007152.
    • Vancouver/ICMJE:
      Christensen SM, Belew AT, El-Sayed NM, Tafuri WL, Silveira FT, Mosser DM. Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensis. Plos Neglected Tropical Diseases [Internet]. 2019 Mar 7 [cited 2019 Dec 11];13(3):e0007152. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=30845223