Fetuin-A is also an adipokine.

Publisher: BioMed Central Country of Publication: England NLM ID: 101147696 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-511X (Electronic) Linking ISSN: 1476511X NLM ISO Abbreviation: Lipids Health Dis

Original Publication: [London] : BioMed Central, 2002-

Diabetes Mellitus/*metabolism ; Metabolic Syndrome/*metabolism ; Obesity/*metabolism ; alpha-2-HS-Glycoprotein/*metabolism; Adipocytes/metabolism ; Adipokines/blood ; Adipokines/metabolism ; Adiponectin/metabolism ; Diabetes Mellitus/blood ; Diabetes Mellitus/genetics ; Diabetes Mellitus/pathology ; Female ; Humans ; Insulin Resistance/genetics ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/genetics ; Metabolic Syndrome/pathology ; Obesity/blood ; Obesity/genetics ; Obesity/pathology ; Subcutaneous Fat/metabolism

Fetuin-A (FetA), which impairs insulin action is considered classically as a hepatokine. In patients with Metabolic Syndrome without the confounding of diabetes or cardiovascular diseases, we showed significant increases in both circulating and subcutaneous adipose tissue secreted Fet-A. Furthermore we showed in mice models increase mRNA and protein following a high fat diet and in a model of metabolic syndrome. This work was recently confirmed by another group of investigators. Hence we propose that Fet-A be considered also as an adipokine.

Nat Rev Endocrinol. 2013 Mar;9(3):144-52. (PMID: 23337953)
Diabetes Metab J. 2015 Feb;39(1):10-5. (PMID: 25729707)
Atherosclerosis. 2015 Jul;241(1):130-7. (PMID: 25978344)
Diabetologia. 2016 Jan;59(1):222-223. (PMID: 26585510)
Endocrine. 2017 Feb;55(2):435-446. (PMID: 27738888)
Lipids Health Dis. 2018 Dec 22;17(1):291. (PMID: 30579336)

0 (Adipokines)
0 (Adiponectin)
0 (alpha-2-HS-Glycoprotein)

Date Created: 20190329 Date Completed: 20190726 Latest Revision: 20200225

20240105

PMC6437840

10.1186/s12944-019-1021-8

30917813