Moderate Serum γ-Glutamyl Transferase Level Is Beneficial for Heart Failure After Percutaneous Coronary Intervention.

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  • Additional Information
    • Source:
      Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101150318 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8518 (Electronic) Linking ISSN: 15404196 NLM ISO Abbreviation: Metab Syndr Relat Disord Subsets: MEDLINE
    • Publication Information:
      Original Publication: Larchmont, NY : Mary Ann Liebert, Inc., c2003-
    • Subject Terms:
      Coronary Artery Disease/*therapy ; Heart Failure/*epidemiology ; Percutaneous Coronary Intervention/*adverse effects ; gamma-Glutamyltransferase/*blood; Aged ; Biomarkers/blood ; China/epidemiology ; Coronary Artery Disease/blood ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/epidemiology ; Female ; Heart Failure/blood ; Heart Failure/diagnosis ; Humans ; Incidence ; Male ; Middle Aged ; Predictive Value of Tests ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome ; Up-Regulation
    • Abstract:
      Objective: Previous studies suggested that elevated serum γ-glutamyl transferase (GGT) level is an independent predictor of coronary artery disease (CAD) and heart failure (HF). However, whether serum GGT level has a predictive role for HF after percutaneous coronary intervention (PCI) remains unclear. This study aimed to evaluate the association of GGT with HF after PCI in a Chinese population. Methods: Five thousand six hundred thirty-eight patients were divided into three groups according to GGT tertiles: first tertile (GGT <19.6 U/L; n  = 1875), second tertile (GGT ≥19.6-32.9 U/L; n  = 1880), and third tertile (GGT ≥32.9 U/L; n  = 1883). There were 165 (2.9%) HFs during a long-term follow-up. The average follow-up time was 35.9 ± 22.6 months. Results: The incidence of HF in the first tertile is 62 (3.3%), second tertile is 38 (2.0%), and third tertile is 65 (3.5%). The HF incidence was significantly lower in second tertile compared with that in the first tertile or in the third tertile (both P  < 0.05). A U-shaped curve was observed according to quintiles (Q1:3.4%, Q2: 3.0, Q3:1.6%, Q4: 2.9%, Q5: 3.7%, P  = 0.042). The multivariate Cox proportional hazards model showed after adjustment of confounders, the association remains significant ( P  = 0.046). Conclusions: This study indicated that serum GGT concentration was independently associated with HF after PCI. The baseline serum GGT level less than 19.6 or ≥32.9 increases HF risk in CAD patients who underwent PCI.
    • Contributed Indexing:
      Keywords: coronary artery disease*; heart failure*; percutaneous coronary intervention*; γ-glutamyl transferase*
    • Accession Number:
      0 (Biomarkers)
      EC 2.3.2.2 (gamma-Glutamyltransferase)
      EC 2.3.2.2 (gamma-glutamyltransferase, human)
    • Publication Date:
      Date Created: 20190417 Date Completed: 20200601 Latest Revision: 20200601
    • Publication Date:
      20220301
    • Accession Number:
      10.1089/met.2019.0009
    • Accession Number:
      30990355