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Endoplasmic reticulum and the microRNA environment in the cardiovascular system 1 .
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- Author(s): Groenendyk J;Groenendyk J; Fan X; Fan X; Peng Z; Peng Z; Kurgan L; Kurgan L; Kurgan L; Michalak M; Michalak M
- Source:
Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2019 Jun; Vol. 97 (6), pp. 515-527. Date of Electronic Publication: 2019 May 07.- Publication Type:
Journal Article; Review- Language:
English - Source:
- Additional Information
- Source: Publisher: Canadian Science Publishing Country of Publication: Canada NLM ID: 0372712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1205-7541 (Electronic) Linking ISSN: 00084212 NLM ISO Abbreviation: Can J Physiol Pharmacol Subsets: MEDLINE
- Publication Information: Publication: 2011- : Ottawa, ON : Canadian Science Publishing
Original Publication: Ottawa, National Research Council of Canada. - Subject Terms:
- Abstract: Stress responses are important to human physiology and pathology, and the inability to adapt to cellular stress leads to cell death. To mitigate cellular stress and re-establish homeostasis, cells, including those in the cardiovascular system, activate stress coping response mechanisms. The endoplasmic reticulum, a component of the cellular reticular network in cardiac cells, mobilizes so-called endoplasmic reticulum stress coping responses, such as the unfolded protein response. MicroRNAs play an important part in the maintenance of cellular and tissue homeostasis, perform a central role in the biology of the cardiac myocyte, and are involved in pathological cardiac function and remodeling. In this paper, we review a link between endoplasmic reticulum homeostasis and microRNA with an emphasis on the impact on stress responses in the cardiovascular system.
- Contributed Indexing: Keywords: ER stress; cœur; endoplasmic reticulum; heart; microRNA; réponse UPR; réticulum endoplasmique; stress du RE; unfolded protein response
- Accession Number: 0 (MicroRNAs)
- Publication Date: Date Created: 20190508 Date Completed: 20191104 Latest Revision: 20191104
- Publication Date: 20240105
- Accession Number: 10.1139/cjpp-2018-0720
- Accession Number: 31063413
- Source:
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