Endoplasmic reticulum and the microRNA environment in the cardiovascular system 1 .

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  • Additional Information
    • Source:
      Publisher: Canadian Science Publishing Country of Publication: Canada NLM ID: 0372712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1205-7541 (Electronic) Linking ISSN: 00084212 NLM ISO Abbreviation: Can J Physiol Pharmacol Subsets: MEDLINE
    • Publication Information:
      Publication: 2011- : Ottawa, ON : Canadian Science Publishing
      Original Publication: Ottawa, National Research Council of Canada.
    • Subject Terms:
    • Abstract:
      Stress responses are important to human physiology and pathology, and the inability to adapt to cellular stress leads to cell death. To mitigate cellular stress and re-establish homeostasis, cells, including those in the cardiovascular system, activate stress coping response mechanisms. The endoplasmic reticulum, a component of the cellular reticular network in cardiac cells, mobilizes so-called endoplasmic reticulum stress coping responses, such as the unfolded protein response. MicroRNAs play an important part in the maintenance of cellular and tissue homeostasis, perform a central role in the biology of the cardiac myocyte, and are involved in pathological cardiac function and remodeling. In this paper, we review a link between endoplasmic reticulum homeostasis and microRNA with an emphasis on the impact on stress responses in the cardiovascular system.
    • Contributed Indexing:
      Keywords: ER stress; cœur; endoplasmic reticulum; heart; microRNA; réponse UPR; réticulum endoplasmique; stress du RE; unfolded protein response
    • Accession Number:
      0 (MicroRNAs)
    • Publication Date:
      Date Created: 20190508 Date Completed: 20191104 Latest Revision: 20191104
    • Publication Date:
      20240105
    • Accession Number:
      10.1139/cjpp-2018-0720
    • Accession Number:
      31063413