Mycoplasma Genitalium and Mycoplasma Hominis are prevalent and correlated with HIV risk in MSM: a cross-sectional study in Shenyang, China.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis
    • Publication Information:
      Original Publication: London : BioMed Central, [2001-
    • Subject Terms:
      HIV Infections/*epidemiology ; Homosexuality, Male/*statistics & numerical data ; Mycoplasma Infections/*epidemiology ; Mycoplasma genitalium/*isolation & purification ; Mycoplasma hominis/*isolation & purification ; Sexual and Gender Minorities/*statistics & numerical data; AIDS-Related Opportunistic Infections/epidemiology ; AIDS-Related Opportunistic Infections/microbiology ; Adolescent ; Adult ; China/epidemiology ; Cross-Sectional Studies ; HIV ; HIV Infections/microbiology ; Humans ; Male ; Mass Screening ; Mycoplasma Infections/microbiology ; Prevalence ; Risk Factors ; Sexual Partners ; Sexually Transmitted Diseases/classification ; Sexually Transmitted Diseases/epidemiology ; Sexually Transmitted Diseases/microbiology ; Young Adult
    • Abstract:
      Background: A high proportion of men who have sex with men (MSM) use geosocial networking apps (Apps) to seek partners. However, the relationship of app use with HIV risk is unknown. Further, the risks of some sexually transmitted infection (STIs), including Mycoplasma genitalium, have seldom been studied among MSM.
      Methods: MSM were enrolled at a community-based HIV testing site in Shenyang, China. After completing a questionnaire survey, we collected rectal swabs and venous blood specimens. We then simultaneously tested for ten STIs (Chlamydia trachomatis [CT], Neisseria gonorrhea [NG], Ureaplasma urealyticum [Uu], Ureaplasma parvum species [Up1, Up3, Up6, Up14), Mycoplasma hominis [Mh], Mycoplasma genitalium [Mg], and Herpes Simplex Virus Type 2 (HSV-2) using multiple PCR. We also performed blood tests for HIV, Syphilis, Hepatitis C antibody (HCV-Ab), Hepatitis B Surface Antigen (HBsAg), and Hepatitis A-IgM (HAV-IgM), etc. RESULTS: One hundred and eighty-three MSM participated in this study, of which 51.4% reported seeking partners through apps in the past year. The prevalence of HIV was 19.7%, Syphilis 12.0%, HAV 1.1%, rectal Mg 15.3% and Mh 7.1%. Multivariable logistic regression showed that HIV infection was independently correlated with app-using behavior (adjusted odds ratio[aOR] = 2.6), Mg infection (aOR = 3.2), Mh infection (aOR = 4.1) and Syphilis infection (aOR = 3.1) (each P < 0.05).
      Conclusions: App use, Mg, Mh and Syphilis infection were correlated with higher HIV Risk in MSM. Geosocial networking apps should be utilized for HIV interventions targeting MSM. There is a need for more expansive STIs screening, particularly for Mg, Mh and Syphilis in MSM.
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    • Grant Information:
      81872674 National Natural Science Foundation of China; 71573275 National Natural Science Foundation of China
    • Contributed Indexing:
      Keywords: Geosocial networking apps; HIV; Men who have sex with men; Mycoplasma genitalium; Mycoplasma hominis; Sexually transmitted infection; Syphilis
    • Publication Date:
      Date Created: 20190606 Date Completed: 20190731 Latest Revision: 20200225
    • Publication Date:
      20240105
    • Accession Number:
      PMC6549264
    • Accession Number:
      10.1186/s12879-019-4138-5
    • Accession Number:
      31164096