Cellular immune responses to Plasmodium falciparum antigens in Gambian children during and after an acute attack of falciparum malaria.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 0057202 Publication Model: Print Cited Medium: Print ISSN: 0009-9104 (Print) Linking ISSN: 00099104 NLM ISO Abbreviation: Clin Exp Immunol Subsets: MEDLINE
    • Publication Information:
      Publication: 2022- : Oxford : Oxford University Press
      Original Publication: Oxford : Blackwell Scientific Publications
    • Subject Terms:
      Lymphocyte Activation*; Antigens, Protozoan/*immunology ; Malaria/*immunology ; Plasmodium falciparum/*immunology; Acute Disease ; Adolescent ; Animals ; Cell Division ; Child ; Child, Preschool ; Female ; Humans ; Immunity, Cellular ; Infant ; Interferon-gamma/biosynthesis ; Lymphocytes/pathology ; Malaria/blood ; Male
    • Abstract:
      Peripheral blood mononuclear cells from 63 Gambian children with acute Plasmodium falciparum malaria were examined for lymphoproliferation and interferon-gamma (IFN) production in response to stimulation by mitogens, malaria antigens and other soluble antigens. Mitogen or Candida-induced proliferation was not depressed during acute infection but was enhanced 2 to 4 weeks after treatment. Responses to partially purified soluble P. falciparum antigens were minimal or absent in all children in the acute phase but approximately 50% of the children responded by proliferation or IFN-gamma production during the 2 to 8 week convalescent period. These proliferative responses were severely depressed in the presence of the patient's own serum. Nine children with significant convalescent phase proliferative responses were re-examined several months after acute infection. Of these, four remained responsive for at least 8 months in the probable absence of reinfection.
    • References:
      Lancet. 1969 Jul 26;2(7613):201-5. (PMID: 4183149)
      Lancet. 1972 Jan 22;1(7743):169-72. (PMID: 4109547)
      Clin Exp Immunol. 1974 Aug;17(4):647-56. (PMID: 4219844)
      Clin Exp Immunol. 1976 Mar;23(3):471-6. (PMID: 780013)
      Clin Exp Immunol. 1977 Sep;29(3):401-7. (PMID: 73436)
      Clin Exp Immunol. 1979 Feb;35(2):202-9. (PMID: 373935)
      Immunology. 1980 Oct;41(2):421-30. (PMID: 7439934)
      Acta Pathol Microbiol Scand C. 1980 Oct;88(5):263-70. (PMID: 6781221)
      Infect Immun. 1980 Dec;30(3):781-5. (PMID: 6453096)
      Acta Pathol Microbiol Scand C. 1981 Apr;89(2):99-103. (PMID: 7027738)
      J Immunol. 1981 Nov;127(5):1889-93. (PMID: 7028864)
      Trans R Soc Trop Med Hyg. 1982;76(3):422-3. (PMID: 6180528)
      Clin Immunol Immunopathol. 1983 Apr;27(1):38-50. (PMID: 6347486)
      Clin Exp Immunol. 1983 Aug;53(2):335-44. (PMID: 6349879)
      Clin Exp Immunol. 1983 Aug;53(2):345-53. (PMID: 6192953)
      Infect Immun. 1984 Feb;43(2):664-9. (PMID: 6363296)
      J Immunol. 1984 Sep;133(3):1601-8. (PMID: 6431003)
      Clin Exp Immunol. 1984 Nov;58(2):380-7. (PMID: 6209042)
      Trans R Soc Trop Med Hyg. 1985;79(4):497-9. (PMID: 2417392)
      J Infect Dis. 1986 Apr;153(4):763-71. (PMID: 2936834)
      Parasite Immunol. 1986 Jan;8(1):57-68. (PMID: 2421226)
      Scand J Immunol. 1986 Jul;24(1):73-81. (PMID: 2425416)
      Parasite Immunol. 1986 Nov;8(6):551-64. (PMID: 3543809)
      Clin Exp Immunol. 1987 Apr;68(1):65-77. (PMID: 3498567)
      Acta Pathol Microbiol Immunol Scand C. 1987 Dec;95(6):257-63. (PMID: 3327360)
      Clin Exp Immunol. 1988 Mar;71(3):377-82. (PMID: 3133141)
      J Immunol. 1985 Nov;135(5):3498-504. (PMID: 3930605)
    • Accession Number:
      0 (Antigens, Protozoan)
      82115-62-6 (Interferon-gamma)
    • Publication Date:
      Date Created: 19880701 Date Completed: 19881117 Latest Revision: 20181113
    • Publication Date:
      20240104
    • Accession Number:
      PMC1541481
    • Accession Number:
      3139343