Tailoring synthetic polymeric biomaterials towards nerve tissue engineering: a review.

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  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 101594777 Publication Model: Print Cited Medium: Internet ISSN: 2169-141X (Electronic) Linking ISSN: 21691401 NLM ISO Abbreviation: Artif Cells Nanomed Biotechnol Subsets: MEDLINE
    • Publication Information:
      Publication: 2015- : Abingdon, Oxford : Taylor & Francis
      Original Publication: London : Informa Healthcare, [2013]-
    • Subject Terms:
      Biocompatible Materials/*chemistry ; Biocompatible Materials/*pharmacology ; Nerve Tissue/*cytology ; Nerve Tissue/*drug effects ; Polymers/*chemistry ; Polymers/*pharmacology ; Tissue Engineering/*methods; Animals ; Biocompatible Materials/chemical synthesis ; Humans ; Polymers/chemical synthesis
    • Abstract:
      The nervous system is known as a crucial part of the body and derangement in this system can cause potentially lethal consequences or serious side effects. Unfortunately, the nervous system is unable to rehabilitate damaged regions following seriously debilitating disorders such as stroke, spinal cord injury and brain trauma which, in turn, lead to the reduction of quality of life for the patient. Major challenges in restoring the damaged nervous system are low regenerative capacity and the complexity of physiology system. Synthetic polymeric biomaterials with outstanding properties such as excellent biocompatibility and non-immunogenicity find a wide range of applications in biomedical fields especially neural implants and nerve tissue engineering scaffolds. Despite these advancements, tailoring polymeric biomaterials for design of a desired scaffold is fundamental issue that needs tremendous attention to promote the therapeutic benefits and minimize adverse effects. This review aims to (i) describe the nervous system and related injuries. Then, (ii) nerve tissue engineering strategies are discussed and (iii) physiochemical properties of synthetic polymeric biomaterials systematically highlighted. Moreover, tailoring synthetic polymeric biomaterials for nerve tissue engineering is reviewed.
    • Contributed Indexing:
      Keywords: Synthetic polymeric biomaterials; nerve tissue engineering; physiochemical properties
    • Accession Number:
      0 (Biocompatible Materials)
      0 (Polymers)
    • Publication Date:
      Date Created: 20190823 Date Completed: 20200113 Latest Revision: 20200113
    • Publication Date:
      20240105
    • Accession Number:
      10.1080/21691401.2019.1639723
    • Accession Number:
      31437011