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Role of Vitamin D Receptor Gene Polymorphisms on the Susceptibility to Periodontitis: A Meta-Analysis of a Controversial Issue.
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- Author(s): Wan QS;Wan QS; Li L; Li L; Yang SK; Yang SK; Liu ZL; Liu ZL; Song N; Song N
- Source:
Genetic testing and molecular biomarkers [Genet Test Mol Biomarkers] 2019 Sep; Vol. 23 (9), pp. 618-633. Date of Electronic Publication: 2019 Aug 26.- Publication Type:
Journal Article; Meta-Analysis- Language:
English - Source:
- Additional Information
- Source: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101494210 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-0257 (Electronic) Linking ISSN: 19450257 NLM ISO Abbreviation: Genet Test Mol Biomarkers Subsets: MEDLINE
- Publication Information: Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc.
- Subject Terms:
- Abstract: Background: To assess whether vitamin D receptor ( VDR ) gene polymorphisms influence the susceptibility to periodontitis. Methods: We retrieved 34 relevant studies, comprising a total of 3848 subjects suffering from periodontitis and 3470 controls for this meta-analysis. The pooled data were analyzed using STATA software. Results: Among all ethnic groups examined, the VDR Bsm I polymorphism was associated with periodontitis under the recessive model (odds ratio [OR] = 0.722, 95% confidence interval [CI]: 0.532-0.980, p = 0.037). There was also a link between the VDR Fok I polymorphism and periodontitis in the overall population (dominant model: OR = 1.459, 95% CI: 1.050-2.028, p = 0.025 and allelic model: OR = 1.386, 95% CI: 1.026-1.874, p = 0.034) and in Chinese participants (dominant model: OR = 1.813, 95% CI: 1.185-2.774, p = 0.006; allelic model: OR = 1.602, 95% CI: 1.044-2.459, p = 0.031) when stratified by race. The Fok I variant was also correlated with aggressive periodontitis (AP) (dominant model: OR = 2.204, 95% CI: 1.148-4.231, p = 0.018; allelic model: OR = 2.017, 95% CI: 1.365-2.980, p = 0.000; and recessive model: OR = 2.903, 95% CI: 1.520-5.542, p = 0.001). We also showed a correlation between the VDR Taq I variant and periodontitis susceptibility in Caucasian populations (dominant model: OR = 0.525, 95% CI: 0.318-0.866, p = 0.012). The results revealed that there was no relationship between the VDR Apa I gene polymorphism and periodontitis. Conclusions: There was a link between the VDR Bsm I and Fok I gene polymorphisms and periodontitis in the overall population. In addition, the Fok I polymorphism was correlated with AP. There was a link between the Taq I polymorphism and periodontitis in the Caucasian population. The VDR Apal variant, however, was not correlated with periodontitis.
- Contributed Indexing: Keywords: gene polymorphism; periodontitis; pooled analysis; vitamin D receptor
- Accession Number: 0 (Receptors, Calcitriol)
- Publication Date: Date Created: 20190827 Date Completed: 20200206 Latest Revision: 20221207
- Publication Date: 20240105
- Accession Number: 10.1089/gtmb.2019.0021
- Accession Number: 31448964
- Source:
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