Interstitial-resident memory CD8 + T cells sustain frontline epithelial memory in the lung.

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  • Additional Information
    • Source:
      Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, NY : Rockefeller University Press
    • Subject Terms:
      Immunologic Memory*; Alveolar Epithelial Cells/*immunology ; CD8-Positive T-Lymphocytes/*immunology ; Parenchymal Tissue/*immunology; Animals ; CD8-Positive T-Lymphocytes/metabolism ; Immunophenotyping ; Lung/immunology ; Lung/metabolism ; Lymphocyte Activation/immunology ; Mice ; Models, Biological ; Parenchymal Tissue/metabolism ; Receptors, CXCR6/metabolism ; Respiratory Mucosa/immunology ; Respiratory Mucosa/metabolism
    • Abstract:
      Populations of CD8 + lung-resident memory T (T RM ) cells persist in the interstitium and epithelium (airways) following recovery from respiratory virus infections. While it is clear that CD8 + T RM cells in the airways are dynamically maintained via the continuous recruitment of new cells, there is a vigorous debate about whether tissue-circulating effector memory T (T EM ) cells are the source of these newly recruited cells. Here we definitively demonstrate that CD8 + T RM cells in the lung airways are not derived from T EM cells in the circulation, but are seeded continuously by T RM cells from the lung interstitium. This process is driven by CXCR6 that is expressed uniquely on T RM cells but not T EM cells. We further demonstrate that the lung interstitium CD8 + T RM cell population is also maintained independently of T EM cells via a homeostatic proliferation mechanism. Taken together, these data show that lung memory CD8 + T RM cells in the lung interstitium and airways are compartmentally separated from T EM cells and clarify the mechanisms underlying their maintenance.
      (© 2019 Takamura et al.)
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    • Accession Number:
      0 (Cxcr6 protein, mouse)
      0 (Receptors, CXCR6)
    • Publication Date:
      Date Created: 20190928 Date Completed: 20200615 Latest Revision: 20200615
    • Publication Date:
      20240105
    • Accession Number:
      PMC6888985
    • Accession Number:
      10.1084/jem.20190557
    • Accession Number:
      31558614