GAS5, a FoxO1-actived long noncoding RNA, promotes propofol-induced oral squamous cell carcinoma apoptosis by regulating the miR-1297-GSK3β axis.

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  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 101594777 Publication Model: Print Cited Medium: Internet ISSN: 2169-141X (Electronic) Linking ISSN: 21691401 NLM ISO Abbreviation: Artif Cells Nanomed Biotechnol Subsets: MEDLINE
    • Publication Information:
      Publication: 2015- : Abingdon, Oxford : Taylor & Francis
      Original Publication: London : Informa Healthcare, [2013]-
    • Subject Terms:
      Apoptosis/*genetics ; Carcinoma, Squamous Cell/*pathology ; Glycogen Synthase Kinase 3 beta/*metabolism ; MicroRNAs/*genetics ; Mouth Neoplasms/*pathology ; Propofol/*pharmacology ; RNA, Long Noncoding/*genetics; Antineoplastic Agents/pharmacology ; Base Sequence ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Forkhead Box Protein O1/metabolism ; Humans ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Up-Regulation/drug effects ; Up-Regulation/genetics
    • Abstract:
      Propofol, an intravenous anaesthetic agent, has been found to exhibit antitumour effects in various kinds of cancer cells. However, the potential roles and regulatory mechanisms of propofol in oral squamous cell carcinoma (OSCC) remain unknown. Herein, we found that propofol inhibits OSCC cell growth and promotes cell apoptosis in a dose- and time-dependent manner. Further mechanistic studies revealed that the long noncoding RNA GAS5 is induced by propofol in OSCC cells. Elevated GAS5 acts as a competing endogenous RNA for miR-1297 and attenuates its inhibitory effect on GSK3β, leading to GSK3β increase and Mcl1 decrease. Additionally, we found that FoxO1 binds to the promoter of GAS5, facilitating its transcription in response to propofol treatment. Thus, these results suggest that propofol exhibits antitumour effects in OSCC cells and that the FoxO1-GAS5-miR-1297-GSK3β axis plays an important role in propofol-induced OSCC cell apoptosis.
    • Contributed Indexing:
      Keywords: GAS5; LncRNAs; OSCC; apoptosis
    • Accession Number:
      0 (Antineoplastic Agents)
      0 (Forkhead Box Protein O1)
      0 (GAS5 long non-coding RNA, human)
      0 (MIRN1297 microRNA, human)
      0 (MicroRNAs)
      0 (RNA, Long Noncoding)
      EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
      YI7VU623SF (Propofol)
    • Publication Date:
      Date Created: 20191005 Date Completed: 20200218 Latest Revision: 20200218
    • Publication Date:
      20240104
    • Accession Number:
      10.1080/21691401.2019.1670189
    • Accession Number:
      31583913