Cerebrospinal fluid and optic nerve sheath compartment syndrome: A common pathophysiological mechanism in five different cases?

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Pub. Asia Country of Publication: Australia NLM ID: 100896531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1442-9071 (Electronic) Linking ISSN: 14426404 NLM ISO Abbreviation: Clin Exp Ophthalmol Subsets: MEDLINE
    • Publication Information:
      Publication: Carlton, Vic. : Wiley-Blackwell Pub. Asia
      Original Publication: Carlton, Vic. : Blackwell Science Asia, c2000-
    • Subject Terms:
    • Abstract:
      Importance: Optic nerve (ON) dysfunction is a common feature of different diseases. The pathophysiology is not yet fully understood.
      Background: This study describes five patients with ON sheath (ONS) compartment syndrome (ONSCS) and contributes to the hypothesis that impaired cerebrospinal fluid (CSF) flow can play a role in the development of ON dysfunction.
      Design: Retrospective case series.
      Participants: Five patients with ONSCS were included in the study.
      Methods: Elaboration of medical histories and clinical and diagnostic findings over a long time period was carried out by analysing medical records and by a detailed medical consultation.
      Main Outcome Measures: The main outcome measures include clinical history; visual acuity; field, intraocular and CSF pressures; and contrast-loaded computed tomographic (CT) cisternography.
      Results: Compartmentation of the ONS demonstrated by contrast-loaded CT cisternography was the consistent finding in all five patients who demonstrated findings of ON dysfunction. The aetiologies varied and included meningitis, papilloedema, sphenoid wing meningioma, disc herniation and normal-tension glaucoma.
      Conclusion and Relevance: Compartmentation of the ONS with consecutively impaired CSF dynamics within the ON subarachnoid space can lead to ON dysfunction. Different aetiologies can cause the development of ONSCS.
      (© 2019 Royal Australian and New Zealand College of Ophthalmologists.)
    • Comments:
      Comment in: Clin Exp Ophthalmol. 2020 Mar;48(2):271-272. (PMID: 31850613)
      Comment in: Clin Exp Ophthalmol. 2020 Mar;48(2):272-273. (PMID: 31850617)
    • References:
      Raper D, Louveau A, Kipnis J. How do meningeal lymphatic vessels drain the CNS? Trends Neurosci. 2016;39(9):581-586.
      Benveniste H, Liu X, Koundal S, Sanggaard S, Lee H, Wardlaw J. The glymphatic system and waste clearance with brain aging: a review. Gerontology. 2019;65(2):106-119.
      Hladky SB, Barrand MA. Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood-brain barrier. Fluids Barriers CNS. 2018;15(1):30.
      Louveau A, Smirnov I, Keyes TJ, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523(7560):337-341.
      Alvermann S, Hennig C, Stuve O, Wiendl H, Stangel M. Immunophenotyping of cerebrospinal fluid cells in multiple sclerosis: in search of biomarkers. JAMA Neurol. 2014;71(7):905-912.
      Killer HE, Laeng HR, Flammer J, Groscurth P. Architecture of arachnoid trabeculae, pillars, and septa in the subarachnoid space of the human optic nerve: anatomy and clinical considerations. Br J Ophthalmol. 2003;87(6):777-781.
      Killer HE, Miller NR, Flammer J, et al. Cerebrospinal fluid exchange in the optic nerve in normal-tension glaucoma. Br J Ophthalmol. 2012;96(4):544-548.
      Pircher A, Montali M, Pircher J, Berberat J, Remonda L, Killer HE. Perioptic cerebrospinal fluid dynamics in idiopathic intracranial hypertension. Front Neurol. 2018;9:506.
      Pircher A, Montali M, Wostyn P, et al. Impaired cerebrospinal fluid dynamics along the entire optic nerve in normal-tension glaucoma. Acta Ophthalmol. 2018;96(5):e562-e569.
      Killer HE, Jaggi GP, Flammer J, Miller NR, Huber AR. The optic nerve: a new window into cerebrospinal fluid composition? Brain. 2006;129(pt 4):1027-1030.
      Xin X, Huber A, Meyer P, et al. L-PGDS (betatrace protein) inhibits astrocyte proliferation and mitochondrial ATP production in vitro. J Mol Neurosci. 2009;39(3):366-371.
      Maesaka JK, Sodam B, Palaia T, et al. Prostaglandin D2 synthase: apoptotic factor in Alzheimer plasma, inducer of reactive oxygen species, inflammatory cytokines and dialysis dementia. J Nephropathol. 2013;2(3):166-180.
      Killer HE, Subramanian PS. Compartmentalized cerebrospinal fluid. Int Ophthalmol Clin. 2014;54(1):95-102.
      Killer HE, Jaggi GP, Miller NR, et al. Cerebrospinal fluid dynamics between the basal cisterns and the subarachnoid space of the optic nerve in patients with papilloedema. Br J Ophthalmol. 2011;95(6):822-827.
      Hayreh SS. Pathogenesis of optic disc edema in raised intracranial pressure. Prog Retin Eye Res. 2016;50:108-144.
      Jaggi GP, Harlev M, Ziegler U, Dotan S, Miller NR, Killer HE. Cerebrospinal fluid segregation optic neuropathy: an experimental model and a hypothesis. Br J Ophthalmol. 2010;94(8):1088-1093.
      Xin X, Fan B, Flammer J, et al. Meningothelial cells react to elevated pressure and oxidative stress. PLoS One. 2011;6(5):e20142.
      Shaw PJ. Toxicity of CSF in motor neurone disease: a potential route to neuroprotection. Brain. 2002;125(pt 4):693-694.
      Killer HE, Jaggi GP, Flammer J, Miller NR. Is open-angle glaucoma caused by impaired cerebrospinal fluid circulation: around the optic nerve? Clin Experiment Ophthalmol. 2008;36(4):308-311.
      Brisby H, Olmarker K, Larsson K, Nutu M, Rydevik B. Proinflammatory cytokines in cerebrospinal fluid and serum in patients with disc herniation and sciatica. Eur Spine J. 2002;11(1):62-66.
      Bershad EM, Urfy MZ, Calvillo E, et al. Marked olfactory impairment in idiopathic intracranial hypertension. J Neurol Neurosurg Psychiatry. 2014;85(9):959-964.
      Kotecha AM, Correa ADC, Fisher KM, Rushworth JV. Olfactory dysfunction as a global biomarker for sniffing out Alzheimer's disease: a meta-analysis. Biosensors (Basel). 2018;8(2):41.
      Silva MME, Mercer PBS, Witt MCZ, Pessoa RR. Olfactory dysfunction in Alzheimer's disease systematic review and meta-analysis. Dement Neuropsychol. 2018;12(2):123-132.
      Woodward MR, Dwyer MG, Bergsland N, et al. Olfactory identification deficit predicts white matter tract impairment in Alzheimer's disease. Psychiatry Res Neuroimaging. 2017;266:90-95.
      Gugleta K, Kochkorov A, Katamay R, et al. Olfactory function in primary open-angle glaucoma patients. Klin Monbl Augenheilkd. 2010;227(4):277-279.
      Wesson DW, Levy E, Nixon RA, Wilson DA. Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model. J Neurosci. 2010;30(2):505-514.
      Yi HA, Moller C, Dieleman N, et al. Relation between subcortical grey matter atrophy and conversion from mild cognitive impairment to Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2016;87(4):425-432.
      Giorgio A, Zhang J, Costantino F, De Stefano N. Diffuse brain damage in normal tension glaucoma. Hum Brain Mapp. 2018;39(1):532-541.
      Mancino R, Martucci A, Cesareo M, et al. Glaucoma and Alzheimer disease: one age-related neurodegenerative disease of the brain. Curr Neuropharmacol. 2018;16(7):971-977.
      Wostyn P, Van Dam D, De Deyn PP. Alzheimer's disease and glaucoma: look-alike neurodegenerative diseases. Alzheimers Dement. 2019;15(4):600-601.
      Wostyn P, De Groot V, Van Dam D, Audenaert K, Killer HE, De Deyn PP. Glaucoma considered as an imbalance between production and clearance of neurotoxins. Invest Ophthalmol Vis Sci. 2014;55(8):5351-5352.
      Yang D, Fu J, Hou R, et al. Glaucoma considered as an imbalance between production and clearance of neurotoxins. Invest Ophthalmol Vis Sci. 2014;55(8):5353.
      Jungen MJ, Ter Meulen BC, van Osch T, Weinstein HC, Ostelo R. Inflammatory biomarkers in patients with sciatica: a systematic review. BMC Musculoskelet Disord. 2019;20(1):156.
      Skouen JS, Larsen JL, Vollset E, Gronning M. Elevated cerebrospinal fluid proteins in sciatica caused by disc herniation. Eur Spine J. 1994;3(2):107-111.
      Fan B, Bordigari G, Flammer J, Killer HE, Meyer P, Neutzner A. Meningothelial cells participate in immunological processes in the cerebrospinal fluid. J Neuroimmunol. 2012;244(1-2):45-50.
      Li J, Fang L, Killer HE, Flammer J, Meyer P, Neutzner A. Meningothelial cells as part of the central nervous system host defence. Biol Cell. 2013;105(7):304-315.
      Li J, Fang L, Meyer P, Killer HE, Flammer J, Neutzner A. Anti-inflammatory response following uptake of apoptotic bodies by meningothelial cells. J Neuroinflammation. 2014;11:35.
      Pache M, Meyer P. Morphological changes of the retrobulbar optic nerve and its meningeal sheaths in glaucoma. Ophthalmologica. 2006;220(6):393-396.
      Jaggi GP, Miller NR, Flammer J, Weinreb RN, Remonda L, Killer HE. Optic nerve sheath diameter in normal-tension glaucoma patients. Br J Ophthalmol. 2012;96(1):53-56.
    • Contributed Indexing:
      Keywords: cerebrospinal fluid; cisternography; normal-tension glaucoma and papilloedema; optic nerve sheath compartment syndrome
    • Publication Date:
      Date Created: 20191025 Date Completed: 20210528 Latest Revision: 20210528
    • Publication Date:
      20240104
    • Accession Number:
      10.1111/ceo.13663
    • Accession Number:
      31648390