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Recombinant Porcine Interferon Alpha Enhances Immune Responses to Killed Porcine Reproductive and Respiratory Syndrome Virus Vaccine in Pigs.
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- Author(s): Yu HY;Yu HY; Qu MS; Qu MS; Qu MS; Zhang JL; Zhang JL; Zhang JL; Gan L; Gan L; Gan L; Zhao Y; Zhao Y; Shan XQ; Shan XQ; Zhou W; Zhou W; Xia BB; Xia BB; Chen J; Chen J; Chen J; Wang ML; Wang ML; Wang ML; Zhao J; Zhao J; Zhao J
- Source:
Viral immunology [Viral Immunol] 2019 Nov; Vol. 32 (9), pp. 383-392.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 8801552 Publication Model: Print Cited Medium: Internet ISSN: 1557-8976 (Electronic) Linking ISSN: 08828245 NLM ISO Abbreviation: Viral Immunol Subsets: MEDLINE
- Publication Information: Original Publication: New York, NY : Mary Ann Liebert, Inc., c1987-
- Subject Terms: Immunogenicity, Vaccine*; Adjuvants, Immunologic/*administration & dosage ; Interferon-alpha/*administration & dosage ; Porcine Reproductive and Respiratory Syndrome/*prevention & control ; Porcine respiratory and reproductive syndrome virus/*immunology ; Viral Vaccines/*immunology; Animals ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Viral/blood ; Antibodies, Viral/isolation & purification ; Interferon-alpha/immunology ; Porcine Reproductive and Respiratory Syndrome/blood ; Porcine Reproductive and Respiratory Syndrome/immunology ; Porcine Reproductive and Respiratory Syndrome/virology ; Porcine respiratory and reproductive syndrome virus/isolation & purification ; Recombinant Proteins/administration & dosage ; Sus scrofa ; Swine ; Vaccination/methods ; Vaccination/veterinary ; Vaccines, Inactivated/administration & dosage ; Vaccines, Inactivated/immunology ; Viral Vaccines/administration & dosage
- Abstract: In this study, the immunoadjuvant effects of recombinant porcine interferon alpha (rPoIFN α ) on the killed virus vaccine (KV) of porcine reproductive and respiratory syndrome virus (PRRSV) in pigs were investigated. The experimental pigs were divided into six groups, including normal control group, rPoIFN α control group, PRRSV KV control group, KV+40,000 U rPoIFN α immunization group, KV+400,000 U rPoIFN α immunization group, and KV+4,000,000 U rPoIFN α immunization group. The experimental pigs were boosted immunized on the 28th day after the initial immunization, and the heparinized blood and serum samples were collected at different time points of these two immunizations to detect and evaluate the immune responses of pigs after immunization by ELISA assay, neutralization assay, flow cytometry, and so on. The results showed that the proportion of the levels of PRRSV-specific antibodies, neutralizing antibodies, stimulation index, IL-4, IFN-γ, and lymphocytes within the groups immunized with KV+rPoIFN α were significantly higher than that group immunized with KV alone. The humoral and cellular immune responses in pigs were markedly enhanced by rPoIFN α after the coadministration with KV vaccine. Therefore, we tentatively think that rPoIFN α is a potential immune promoter with prospects for future applications in the pig industry.
- Contributed Indexing: Keywords: adjuvant; cellular immune response; humoral immune response; killed virus vaccine (KV); porcine reproductive and respiratory syndrome virus (PRRSV); recombinant porcine interferon alpha
- Accession Number: 0 (Adjuvants, Immunologic)
0 (Antibodies, Neutralizing)
0 (Antibodies, Viral)
0 (Interferon-alpha)
0 (Recombinant Proteins)
0 (Vaccines, Inactivated)
0 (Viral Vaccines) - Publication Date: Date Created: 20191107 Date Completed: 20200727 Latest Revision: 20200727
- Publication Date: 20240104
- Accession Number: 10.1089/vim.2019.0092
- Accession Number: 31693458
- Source:
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