Dietary patterns and risk of systemic lupus erythematosus in women.

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  • Additional Information
    • Source:
      Publisher: SAGE Publications Country of Publication: England NLM ID: 9204265 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0962 (Electronic) Linking ISSN: 09612033 NLM ISO Abbreviation: Lupus Subsets: MEDLINE
    • Publication Information:
      Publication: London : SAGE Publications
      Original Publication: Houndmills, Basingstoke, Hampshire, UK : Scientific & Medical Division, Macmillan Press Ltd., c1991-
    • Subject Terms:
      Diet, Healthy* ; Diet, Western*; Lupus Erythematosus, Systemic/*etiology; Adult ; Antibodies, Antinuclear/blood ; Diet Records ; Female ; Humans ; Lupus Erythematosus, Systemic/epidemiology ; Middle Aged ; Proportional Hazards Models ; Prospective Studies ; Risk Factors ; Surveys and Questionnaires
    • Abstract:
      Objective: Dietary intake is a complex exposure and a potential risk factor for systemic lupus erythematosus (SLE) due to its impact on lipid and glucose metabolism, oxidative stress, and the intestinal microbiome. We aimed to test whether a prudent dietary pattern is associated with a lower risk of SLE, and whether a Western dietary pattern is associated with a higher risk of SLE.
      Methods: We prospectively investigated two dietary patterns and SLE risk among women in the Nurses' Health Study (NHS, 1984-2014) and Nurses' Health Study II (NHSII, 1991-2015). Food frequency questionnaires were completed every four years. Congruent with prior work in NHS and NHSII, we derived two separate dietary patterns (prudent and Western) using principal component analysis within each cohort. Incident SLE was confirmed by the American College of Rheumatology's 1997 criteria. We estimated hazard ratios (HR) and 95% confidence intervals ( CI ) for SLE by dietary pattern quartiles using Cox models adjusted for time-varying covariates. Models were performed separately in each cohort and results were meta-analyzed. Stratified analyses tested the association of dietary patterns with anti-dsDNA positive SLE and anti-dsDNA negative SLE.
      Results: We confirmed 82 NHS incident SLE cases and 98 NHSII SLE cases during 3,833,054 person-years of follow-up. A higher (healthier) prudent dietary pattern score was not associated with SLE risk (meta-analyzed HR Q4 versus Q1 0.84 [95% CI 0.51, 1.38]). Women with higher (less healthy) Western dietary pattern scores did not have a significantly increased risk for SLE (meta-analyzed HR Q4 versus Q1 1.35 [95% CI 0.77, 2.35]). Results were similar after further adjustment for body mass index. Incident anti-dsDNA positive SLE and anti-dsDNA negative SLE were not associated with either dietary pattern.
      Conclusion: We did not observe a relationship between prudent or Western dietary pattern score and risk of SLE.
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    • Grant Information:
      R01 AR071326 United States AR NIAMS NIH HHS; K23 AR075070 United States AR NIAMS NIH HHS; UM1 CA176726 United States CA NCI NIH HHS; R01 AR057327 United States AR NIAMS NIH HHS; K23 AR069688 United States AR NIAMS NIH HHS; R01 AR049880 United States AR NIAMS NIH HHS; L30 AR070514 United States AR NIAMS NIH HHS; K24 AR066109 United States AR NIAMS NIH HHS; R01 AR059073 United States AR NIAMS NIH HHS; L30 AR066953 United States AR NIAMS NIH HHS; UM1 CA186107 United States CA NCI NIH HHS
    • Contributed Indexing:
      Keywords: Anti-DNA antibodies; musculoskeletal; systemic lupus erythematosus
    • Accession Number:
      0 (Antibodies, Antinuclear)
    • Publication Date:
      Date Created: 20191114 Date Completed: 20200601 Latest Revision: 20211001
    • Publication Date:
      20240105
    • Accession Number:
      PMC6923577
    • Accession Number:
      10.1177/0961203319888791
    • Accession Number:
      31718449