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Cost-effectiveness of QuantiFERON-TB Gold In-Tube versus tuberculin skin test for diagnosis and treatment of Latent Tuberculosis Infection in primary health care workers in Brazil.
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- Author(s): Loureiro RB;Loureiro RB;Loureiro RB; Maciel ELN; Maciel ELN; Maciel ELN; Caetano R; Caetano R; Peres RL; Peres RL; Peres RL; Fregona G; Fregona G; Golub JE; Golub JE; Braga JU; Braga JU
- Source:
PloS one [PLoS One] 2019 Nov 14; Vol. 14 (11), pp. e0225197. Date of Electronic Publication: 2019 Nov 14 (Print Publication: 2019).- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
- Publication Information: Original Publication: San Francisco, CA : Public Library of Science
- Subject Terms: Cost-Benefit Analysis* ; Health Personnel* ; Primary Health Care*; Latent Tuberculosis/*epidemiology ; Tuberculin Test/*methods; Adult ; Aged ; Clinical Decision-Making ; Decision Trees ; Female ; Humans ; Latent Tuberculosis/diagnosis ; Latent Tuberculosis/therapy ; Male ; Mass Screening/economics ; Mass Screening/methods ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity ; Tuberculin Test/economics ; Tuberculin Test/standards ; Young Adult
- Abstract: Objectives: The goal of this study was to perform a cost-effectiveness analysis from the public health system perspective, comparing five strategies for Latent Tuberculosis Infection (LTBI) diagnosis in primary health care workers in Brazil.
Design: Analytical model for decision making, characterized by cost-effectiveness analysis.
Setting: Primary Care Level, considering primary health care workers in Brazil.
Participants: An analytical model for decision making, characterized by a tree of probabilities of events, was developed considering a hypothetical cohort of 10,000 primary health care workers, using the software TreeAge Pro™ 2013 to simulate the clinical and economic impacts of new diagnostic technology (QuantiFERON®-TB Gold in-Tube) versus the traditional tuberculin skin test.
Methods: This model simulated five diagnostic strategies for LTBI in primary health care workers (HCW) in Brazil: tuberculin skin testing using ≥5 mm cut-off, tuberculin skin testing ≥10 mm cut-off, QuantiFERON®-TB Gold in-Tube, tuberculin skin testing using ≥5 mm cut-off confirmed by QuantiFERON®-TB Gold In-Tube if TST positive, tuberculin skin testing using ≥10 mm cut-off confirmed by QuantiFERON®-TB Gold In-Tube if TST positive.
Primary and Secondary Outcome Measures: The outcome measures are the number of individuals correctly classified by the test and the number of Tuberculosis cases avoided.
Results: The most cost-effective strategy was the tuberculin skin test considering ≥10mm cut-off. The isolated use of the QuantiFERON®-TB Gold In-Tube revealed the strategy of lower efficiency with incremental cost-effectiveness ratio (ICER) of US$ 146.05 for each HCW correctly classified by the test.
Conclusions: The tuberculin skin test using ≥10 mm cut-off was the most cost-effective strategy in the diagnosis of Latent Tuberculosis Infection in primary health care works in Brazil.
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Chest. 2010 Feb;137(2):401-9. (PMID: 19793865) - Publication Date: Date Created: 20191115 Date Completed: 20200324 Latest Revision: 20200324
- Publication Date: 20240105
- Accession Number: PMC6855475
- Accession Number: 10.1371/journal.pone.0225197
- Accession Number: 31725786
- Source:
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