Therapeutic potentials and modulatory mechanisms of fatty acids in bone.

Publisher: Published for the Cell Kinetics Society, the European Study Group for Cell Proliferation, and the International Cell Cycle Society by Blackwell Scientific Publications Country of Publication: England NLM ID: 9105195 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2184 (Electronic) Linking ISSN: 09607722 NLM ISO Abbreviation: Cell Prolif Subsets: MEDLINE

Original Publication: [Oxford, England] : Published for the Cell Kinetics Society, the European Study Group for Cell Proliferation, and the International Cell Cycle Society by Blackwell Scientific Publications, 1991-

Bone and Bones/*metabolism ; Fatty Acids/*metabolism; Animals ; Energy Metabolism/physiology ; Humans ; Mesenchymal Stem Cells/metabolism ; Osteoblasts/metabolism ; Osteoclasts/metabolism ; Osteogenesis/physiology

Bone metabolism is a lifelong process that includes bone formation and resorption. Osteoblasts and osteoclasts are the predominant cell types associated with bone metabolism, which is facilitated by other cells such as bone marrow mesenchymal stem cells (BMMSCs), osteocytes and chondrocytes. As an important component in our daily diet, fatty acids are mainly categorized as long-chain fatty acids including polyunsaturated fatty acids (LCPUFAs), monounsaturated fatty acids (LCMUFAs), saturated fatty acids (LCSFAs), medium-/short-chain fatty acids (MCFAs/SCFAs) as well as their metabolites. Fatty acids are closely associated with bone metabolism and associated bone disorders. In this review, we summarized the important roles and potential therapeutic implications of fatty acids in multiple bone disorders, reviewed the diverse range of critical effects displayed by fatty acids on bone metabolism, and elucidated their modulatory roles and mechanisms on specific bone cell types. The evidence supporting close implications of fatty acids in bone metabolism and disorders suggests fatty acids as potential therapeutic and nutritional agents for the treatment and prevention of metabolic bone diseases.
(© 2019 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd.)

Nature. 2014 Jun 5;510(7503):92-101. (PMID: 24899309)
Front Microbiol. 2018 Jun 15;9:1241. (PMID: 29963020)
Biochem Biophys Res Commun. 2010 Nov 26;402(4):602-7. (PMID: 20971068)
J Biol Chem. 1995 Mar 31;270(13):7420-6. (PMID: 7535770)
Int J Mol Sci. 2017 Apr 14;18(4):. (PMID: 28420093)
Mol Cell Biol. 2015 Jun 1;35(11):1979-91. (PMID: 25802278)
J Exp Med. 2005 Mar 7;201(5):713-22. (PMID: 15753205)
Bone. 2003 Jul;33(1):28-37. (PMID: 12919697)
Cell Signal. 2011 Oct;23(10):1633-9. (PMID: 21664461)
Nat Commun. 2018 Jan 4;9(1):55. (PMID: 29302038)
Curr Opin Cell Biol. 2010 Apr;22(2):140-9. (PMID: 20097051)
Gut Microbes. 2018 Jan 2;9(1):84-92. (PMID: 28961041)
Curr Pharm Des. 2009;15(36):4157-64. (PMID: 20041817)
Prog Lipid Res. 2010 Oct;49(4):438-49. (PMID: 20600307)
Sci Rep. 2017 Apr 18;7:46457. (PMID: 28418007)
Molecules. 2013 Nov 15;18(11):14203-27. (PMID: 24248147)
Endocrinology. 2012 Nov;153(11):5275-84. (PMID: 22968644)
Nutrients. 2017 Feb 22;9(2):. (PMID: 28241421)
Ann Rheum Dis. 2015 Jan;74(1):303-10. (PMID: 24285492)
Bone. 2010 Feb;46(2):504-13. (PMID: 19833242)
J Rheumatol. 1999 Apr;26(4):791-9. (PMID: 10229398)
J Biol Chem. 2002 Sep 27;277(39):36024-31. (PMID: 12130649)
Osteoporos Int. 2007 Oct;18(10):1319-28. (PMID: 17566815)
Purinergic Signal. 2010 Sep;6(3):307-15. (PMID: 21103214)
Cancer Metastasis Rev. 2010 Mar;29(1):143-9. (PMID: 20111893)
Front Immunol. 2017 Dec 14;8:1682. (PMID: 29312286)
Biochem Biophys Res Commun. 1997 Apr 17;233(2):336-42. (PMID: 9144535)
Bone. 2000 Nov;27(5):575-84. (PMID: 11062342)
Stem Cells. 2013 Oct;31(10):2183-92. (PMID: 23766271)
PLoS One. 2015 Mar 13;10(3):e0120257. (PMID: 25768019)
Nutrition. 2018 Jan;45:114-124.e4. (PMID: 28965775)
Mol Aspects Med. 2017 Dec;58:57-64. (PMID: 28456616)
J Clin Invest. 2013 Aug;123(8):3409-19. (PMID: 23867625)
Lipids Health Dis. 2017 Oct 10;16(1):197. (PMID: 29017507)
Nutrition. 2018 Oct;54:144-152. (PMID: 29852453)
Joint Bone Spine. 2019 Jul;86(4):451-458. (PMID: 30081198)
Semin Plast Surg. 2009 May;23(2):148-54. (PMID: 20567737)
Aust Dent J. 2019 Jun;64(2):122-134. (PMID: 30811605)
Ann N Y Acad Sci. 2006 Apr;1068:225-33. (PMID: 16831922)
J Exp Clin Cancer Res. 2019 Jan 8;38(1):12. (PMID: 30621730)
Biomed Res Int. 2014;2014:762695. (PMID: 25054145)
J Biol Chem. 2006 Aug 11;281(32):22847-54. (PMID: 16757471)
Br J Nutr. 2015 Sep 28;114(6):885-90. (PMID: 26283657)
Endocrinology. 2008 Sep;149(9):4519-26. (PMID: 18499755)
Arthritis Res Ther. 2005;7(3):R503-12. (PMID: 15899037)
Am J Clin Nutr. 2007 Mar;85(3):803-7. (PMID: 17344503)
Curr Osteoporos Rep. 2015 Apr;13(2):125-30. (PMID: 25616772)
Endocrinology. 2000 Jun;141(6):2054-61. (PMID: 10830290)
Bone Res. 2016 Apr 26;4:16009. (PMID: 27563484)
Inflamm Res. 2016 Aug;65(8):635-45. (PMID: 27056390)
Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1045-50. (PMID: 14722361)
J Periodontal Res. 2009 Apr;44(2):211-6. (PMID: 19210341)
Biochem Biophys Res Commun. 2012 Feb 10;418(2):296-300. (PMID: 22266313)
Oncotarget. 2013 Nov;4(11):2108-23. (PMID: 24240026)
J Nutr Biochem. 2014 Dec;25(12):1254-62. (PMID: 25277647)
Osteoarthritis Cartilage. 2016 May;24(5):942-5. (PMID: 26687823)
Sci Adv. 2017 Nov 08;3(11):eaao1193. (PMID: 29134198)
Mol Cell. 2010 Oct 22;40(2):310-22. (PMID: 20965424)
JPEN J Parenter Enteral Nutr. 2010 Mar-Apr;34(2):151-5. (PMID: 20375422)
Lipids. 2017 Apr;52(4):327-333. (PMID: 28324248)
J Cell Physiol. 2008 Jan;214(1):201-9. (PMID: 17929247)
Semin Plast Surg. 2009 May;23(2):59-72. (PMID: 20567728)
J Signal Transduct. 2011;2011:792639. (PMID: 21637379)
Front Endocrinol (Lausanne). 2016 Jun 17;7:67. (PMID: 27379019)
IUBMB Life. 2012 Oct;64(10):825-34. (PMID: 22941947)
J Cell Biochem. 2016 Oct;117(10):2370-6. (PMID: 27416518)
Int J Endocrinol. 2014;2014:235060. (PMID: 25147565)
J Dent Res. 2016 Feb;95(2):223-9. (PMID: 26450512)
Nutrition. 2017 Jul - Aug;39-40:57-66. (PMID: 28606571)
Endocr Res. 2018 Feb;43(1):29-38. (PMID: 28972408)
Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11924-8. (PMID: 8265649)
Nutr Rev. 2007 Dec;65(12 Pt 2):S147-51. (PMID: 18240539)
Osteoarthritis Cartilage. 2008 Oct;16(10):1267-74. (PMID: 18417374)
ScientificWorldJournal. 2014 Jan 22;2014:595962. (PMID: 24587733)
Ann Rheum Dis. 2015 Nov;74(11):2076-83. (PMID: 25015373)
Braz Dent J. 2018 Mar-Apr;29(2):173-178. (PMID: 29898064)
Bone. 2019 Aug;125:112-121. (PMID: 31100533)
Cancer Lett. 2014 Nov 1;354(1):189-99. (PMID: 25128071)
J Endocrinol Invest. 2010;33(7 Suppl):9-12. (PMID: 20938219)
Sci Rep. 2015 Sep 14;5:14080. (PMID: 26365922)
Osteoporos Int. 2012 Nov;23(11):2615-24. (PMID: 22270860)
Biosci Rep. 2019 Feb 15;39(2):. (PMID: 30674641)
J Clin Invest. 2004 Mar;113(6):846-55. (PMID: 15067317)
PLoS One. 2013 Jun 18;8(6):e66425. (PMID: 23824448)
Cell Death Dis. 2016 May 26;7:e2235. (PMID: 27228350)
Int J Mol Sci. 2017 Jun 29;18(7):. (PMID: 28661441)
Rheumatology (Oxford). 2016 Apr;55(4):607-14. (PMID: 26374913)
Cell Physiol Biochem. 2018;51(1):228-243. (PMID: 30448827)
FASEB J. 2001 Dec;15(14):2556-64. (PMID: 11726530)
J Bone Miner Res. 1998 Jan;13(1):96-106. (PMID: 9443795)
J Clin Invest. 2004 Dec;114(12):1704-13. (PMID: 15599395)
Eur J Immunol. 1998 May;28(5):1689-700. (PMID: 9603476)
Acta Pharmacol Sin. 2016 Jun;37(6):753-62. (PMID: 27157092)
Am J Clin Nutr. 2007 Mar;85(3):647-8. (PMID: 17344483)
Exp Biol Med (Maywood). 2007 Nov;232(10):1275-88. (PMID: 17959840)
Ann Rheum Dis. 2017 Jan;76(1):147-152. (PMID: 27190099)
Nutrients. 2016 Feb 25;8(3):113. (PMID: 26927165)
Nutrients. 2014 Jul 09;6(7):2584-601. (PMID: 25010555)
Int Immunopharmacol. 2010 Jul;10(7):760-8. (PMID: 20399909)
Lab Invest. 2017 Jun;97(6):737-745. (PMID: 28218738)
J Clin Invest. 2006 Nov;116(11):3015-25. (PMID: 17053832)
Biochim Biophys Acta. 2014 Apr;1845(2):248-54. (PMID: 24508774)
In Vitro Cell Dev Biol Anim. 2019 Jan;55(1):45-51. (PMID: 30397855)
Nutrients. 2017 Apr 28;9(5):. (PMID: 28452958)
Int J Mol Med. 2016 Jun;37(6):1542-50. (PMID: 27082436)
Glia. 2007 Jun;55(8):790-800. (PMID: 17390309)
Arch Oral Biol. 2008 Oct;53(10):903-9. (PMID: 18406397)
Front Cell Dev Biol. 2019 Jan 07;6:170. (PMID: 30666305)
Lipids. 2006 Jan;41(1):29-34. (PMID: 16555468)
JCI Insight. 2016 Apr 21;1(5):e85922. (PMID: 27158677)
Prostaglandins Leukot Essent Fatty Acids. 2003 Mar;68(3):213-8. (PMID: 12591005)
NPJ Biofilms Microbiomes. 2015 Sep 23;1:15017. (PMID: 28721234)
FASEB J. 2004 Aug;18(11):1282-4. (PMID: 15208271)
Br J Cancer. 2010 Jan 19;102(2):403-13. (PMID: 19997104)
Asian Pac J Cancer Prev. 2014;15(3):1397-401. (PMID: 24606472)
J Biol Chem. 2013 Mar 1;288(9):6542-51. (PMID: 23335512)
Curr Pharm Des. 2016;22(15):2216-37. (PMID: 26881443)
Eur J Biochem. 1988 Aug 1;175(2):325-9. (PMID: 3402459)
Ann N Y Acad Sci. 2019 Mar;1440(1):36-53. (PMID: 30648276)
Eksp Klin Farmakol. 2016;79(7):16-20. (PMID: 29782740)
Genes Dev. 2007 Nov 15;21(22):2861-73. (PMID: 18006683)
J Biol Chem. 2000 Feb 11;275(6):4453-9. (PMID: 10660618)
J Biol Chem. 2015 Nov 20;290(47):28321-8. (PMID: 26442583)
Exp Ther Med. 2010 Jul;1(4):603-610. (PMID: 22993583)
Clin Lab. 2006;52(9-10):499-509. (PMID: 17078477)
Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7554-E7563. (PMID: 27821775)
Blood Cells Mol Dis. 2001 May-Jun;27(3):677-90. (PMID: 11482883)
FEBS Lett. 2010 Aug 4;584(15):3242-9. (PMID: 20542036)
J Cell Physiol. 2018 May;233(5):3929-3944. (PMID: 28834576)
J Biol Chem. 2000 Mar 17;275(11):8126-32. (PMID: 10713135)
Exp Cell Res. 2007 Jan 1;313(1):168-78. (PMID: 17084841)
Jpn Dent Sci Rev. 2019 Nov;55(1):12-19. (PMID: 30733840)
J Immunol. 2013 Oct 15;191(8):4337-47. (PMID: 24043885)
Physiology (Bethesda). 2015 Jan;30(1):17-29. (PMID: 25559152)
Biochemistry. 2006 Mar 14;45(10):3325-36. (PMID: 16519527)
Mol Nutr Food Res. 2017 Feb;61(2):. (PMID: 27611773)
Glob J Health Sci. 2015 Nov 03;8(7):18-25. (PMID: 26925896)
Nutrition. 1997 Nov-Dec;13(11-12):1002-4. (PMID: 9433724)
J Leukoc Biol. 2010 May;87(5):869-75. (PMID: 20103767)
Nutr Res. 2013 Jul;33(7):521-33. (PMID: 23827126)
Drug Des Devel Ther. 2013 Aug 22;7:849-60. (PMID: 24009413)
Osteoporos Int. 2014 Mar;25(3):1033-41. (PMID: 24121998)
Drug Des Devel Ther. 2013 Jun 28;7:545-52. (PMID: 23843691)
Sci Rep. 2015 Jul 31;5:12724. (PMID: 26226833)
J Immunol. 2013 Jan 15;190(2):689-94. (PMID: 23241890)
Rheumatology (Oxford). 2008 May;47(5):665-9. (PMID: 18362100)
J Nutr Metab. 2012;2012:539426. (PMID: 22570770)
Endocrinology. 2008 Nov;149(11):5688-95. (PMID: 18617622)
Br J Nutr. 2000 Aug;84(2):175-84. (PMID: 11029968)
Arthritis Rheumatol. 2014 Jul;66(7):1779-88. (PMID: 24591481)
Am J Transl Res. 2015 Dec 15;7(12):2527-35. (PMID: 26885254)
J Lipid Res. 2012 Sep;53(9):2002-13. (PMID: 22766885)
Mol Cell. 2005 Apr 15;18(2):143-5. (PMID: 15837416)
Arthritis Rheum. 1988 Jun;31(6):784-8. (PMID: 3260102)
Arthritis Rheum. 1997 Feb;40(2):270-6. (PMID: 9041938)
Osteoporos Int. 2018 Dec;29(12):2611-2621. (PMID: 30194467)
J Biol Chem. 2007 Jul 13;282(28):20715-27. (PMID: 17491024)
Open Biol. 2016 Nov;6(11):. (PMID: 27881737)
FEBS Lett. 2012 Feb 17;586(4):368-72. (PMID: 22245676)
Rheumatology (Oxford). 2016 Feb;55(2):367-76. (PMID: 26370400)
Front Immunol. 2018 Jun 12;9:1300. (PMID: 29946319)
Endocr Rev. 2017 Jun 1;38(3):255-266. (PMID: 28472361)
J Am Coll Cardiol. 2011 Nov 8;58(20):2047-67. (PMID: 22051327)
Br J Nutr. 2012 Jun;107 Suppl 2:S171-84. (PMID: 22591891)
Cell Signal. 2017 Jan;29:226-232. (PMID: 27836739)
Genome Res. 1996 Nov;6(11):1050-5. (PMID: 8938428)
Endocrinology. 2016 Jul;157(7):2621-35. (PMID: 27145004)
Cell. 2002 Jul 26;110(2):163-75. (PMID: 12150925)
Cell Metab. 2010 Feb 3;11(2):136-46. (PMID: 20142101)
Nat Rev Genet. 2012 Jul 18;13(8):576-88. (PMID: 22805710)
Infect Immun. 2016 Mar 24;84(4):1205-1213. (PMID: 26857576)
J Periodontal Implant Sci. 2014 Feb;44(1):25-32. (PMID: 24616831)
J Orthop Res. 2015 Mar;33(3):359-65. (PMID: 25469820)
Osteoarthritis Cartilage. 2011 Sep;19(9):1150-7. (PMID: 21723952)
Am J Clin Nutr. 1999 Jul;70(1):85-90. (PMID: 10393143)
Nutr Cancer. 2014;66(1):68-76. (PMID: 24274259)
Biochemistry (Mosc). 2017 Jul;82(7):826-833. (PMID: 28918747)
Bone. 2007 Jan;40(1):149-59. (PMID: 17010686)
Science. 2000 Sep 1;289(5484):1504-8. (PMID: 10968780)
Osteoarthritis Cartilage. 2017 Sep;25(9):1516-1521. (PMID: 28545881)
Clin Exp Metastasis. 2018 Dec;35(8):797-818. (PMID: 30327985)
J Dent Res. 2014 Aug;93(8):767-73. (PMID: 24970858)
Bone Res. 2017 Oct 04;5:17046. (PMID: 28983411)
Lipids Health Dis. 2003 Nov 17;2:10. (PMID: 14622442)
Nat Rev Endocrinol. 2011 Sep 06;8(2):81-91. (PMID: 21894214)
Physiol Res. 2015;64(4):439-45. (PMID: 25470522)
Biochem Biophys Res Commun. 2014 Jul 18;450(1):777-81. (PMID: 24955854)
Mol Cells. 2014 Aug;37(8):598-604. (PMID: 25134536)
Leuk Res. 2015 Apr;39(4):400-5. (PMID: 25666255)
Curr Top Dev Biol. 2019;133:281-307. (PMID: 30902256)
J Bone Miner Res. 2014;29(5):1183-95. (PMID: 24272998)
Endocrinology. 2015 Nov;156(11):4081-93. (PMID: 26327577)
Exp Cell Res. 2013 Nov 15;319(19):3035-41. (PMID: 23973666)
J Dent Res. 2015 Feb;94(2):362-70. (PMID: 25503900)
Curr Osteoporos Rep. 2019 Jun;17(3):122-128. (PMID: 30905007)
J Biol Chem. 2003 Mar 28;278(13):11303-11. (PMID: 12496284)
Science. 2011 Nov 25;334(6059):1081-6. (PMID: 22116877)
Cell Prolif. 2020 Feb;53(2):e12735. (PMID: 31797479)
Br J Nutr. 2006 Mar;95(3):462-8. (PMID: 16512931)
Biomed Pharmacother. 2018 Jun;102:1099-1104. (PMID: 29710527)
Exp Mol Med. 2012 Feb 29;44(2):73-80. (PMID: 22257882)
Bone. 2019 Oct;127:353-359. (PMID: 31226530)
Biomed Pharmacother. 2019 Mar;111:1228-1233. (PMID: 30841436)
Biochem Pharmacol. 2019 Jul;165:24-32. (PMID: 30825432)
Mol Endocrinol. 2008 Jan;22(1):176-85. (PMID: 17885208)
Prostaglandins Other Lipid Mediat. 2009 Jun;89(1-2):20-5. (PMID: 19464663)
Trends Endocrinol Metab. 2013 Jun;24(6):290-300. (PMID: 23499155)
Crit Rev Immunol. 2014;34(4):347-57. (PMID: 24941160)
Biol Open. 2013 Dec 15;2(12):1382-9. (PMID: 24285710)
World J Hepatol. 2014 Nov 27;6(11):776-82. (PMID: 25429315)
PLoS One. 2015 Apr 13;10(4):e0125145. (PMID: 25867515)
PLoS One. 2013 Sep 16;8(9):e74234. (PMID: 24066124)
Adv Nutr. 2016 Mar 15;7(2):299-312. (PMID: 26980813)
Int J Mol Sci. 2013 Oct 16;14(10):20793-808. (PMID: 24135873)
J Bone Miner Res. 2005 Jan;20(1):15-22. (PMID: 15619665)
Int J Mol Sci. 2016 Jul 25;17(8):. (PMID: 27463711)
J Lipid Res. 2010 May;51(5):892-9. (PMID: 20388920)
Mar Drugs. 2013 Nov 13;11(11):4544-57. (PMID: 24232668)
Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35. (PMID: 21157483)
J Biol Chem. 2004 Apr 23;279(17):16971-9. (PMID: 14966134)
Sci Rep. 2015 Aug 14;5:13092. (PMID: 26271607)
Exp Cell Res. 2017 Mar 15;352(2):293-303. (PMID: 28209487)
Leuk Res. 2015 Jun;39(6):638-45. (PMID: 25846050)
Prostaglandins Leukot Essent Fatty Acids. 2006 Aug;75(2):81-90. (PMID: 16890416)
Odontology. 2005 Sep;93(1):7-15. (PMID: 16170470)
J Immunol. 2016 Sep 15;197(6):2362-8. (PMID: 27534559)
Arch Oral Biol. 2014 Aug;59(8):800-7. (PMID: 24859767)
Arthritis Res Ther. 2018 Aug 3;20(1):163. (PMID: 30075737)
Endocrinology. 2016 Nov;157(11):4094-4103. (PMID: 27689415)
Exp Cell Res. 2004 Oct 15;300(1):159-69. (PMID: 15383323)
J Periodontal Res. 2011 Apr;46(2):261-8. (PMID: 21261621)
J Bone Miner Res. 2005 Jan;20(1):23-9. (PMID: 15619666)
J Periodontal Res. 2014 Apr;49(2):268-74. (PMID: 23721647)
Endocrinology. 1996 Oct;137(10):4189-95. (PMID: 8828476)
J Biol Chem. 2007 Nov 30;282(48):35279-92. (PMID: 17916553)
J Periodontal Res. 2014 Oct;49(5):574-83. (PMID: 25340203)
J Nutr Biochem. 2015 Jul;26(7):713-20. (PMID: 25910895)
J Electron Microsc (Tokyo). 2003;52(6):551-8. (PMID: 14756243)
J Immunol. 2007 Mar 15;178(6):3912-7. (PMID: 17339491)
Arthritis Res Ther. 2010;12(6):R207. (PMID: 21059244)
Osteoporos Int. 2013 May;24(5):1647-61. (PMID: 23104199)
J Bone Miner Metab. 2007;25(1):36-45. (PMID: 17187192)
Am J Clin Nutr. 2005 Apr;81(4):934-8. (PMID: 15817874)
Biosci Rep. 2015 Apr 25;35(3):. (PMID: 26182366)
Stem Cells Dev. 2015 Mar 15;24(6):781-90. (PMID: 25314926)
Intern Med. 2014;53(17):1895-903. (PMID: 25175120)
Cancer Res. 2006 May 1;66(9):4888-94. (PMID: 16651445)
Pol Arch Med Wewn. 2008 Oct;118(10):538-40. (PMID: 19112812)
Nat Clin Pract Rheumatol. 2006 Jan;2(1):35-43. (PMID: 16932650)
Bone. 2016 May;86:119-30. (PMID: 26946132)
Crit Rev Food Sci Nutr. 2019;59(8):1320-1333. (PMID: 29244536)
J Cell Mol Med. 2009 Aug;13(8B):1833-44. (PMID: 20141608)
Bone. 2008 May;42(5):914-20. (PMID: 18316259)
PLoS One. 2011;6(11):e27739. (PMID: 22110749)
J Biomed Mater Res A. 2017 Jul;105(7):2075-2089. (PMID: 28281321)
Bone. 2009 Jun;44(6):1177-85. (PMID: 19233324)
Breast Cancer Res Treat. 2013 Oct;141(3):341-52. (PMID: 24062211)
BMC Nephrol. 2015 Feb 10;16:13. (PMID: 25886405)
Arch Biochem Biophys. 2008 May 15;473(2):132-8. (PMID: 18424258)
Eur J Pharmacol. 2015 Dec 5;768:189-98. (PMID: 26528796)
Prostaglandins Leukot Essent Fatty Acids. 2003 Jun;68(6):387-98. (PMID: 12798659)
Med Sci Monit. 2017 Oct 24;23:5056-5069. (PMID: 29061958)
PLoS One. 2012;7(12):e52583. (PMID: 23300710)
J Clin Invest. 2010 Jan;120(1):357-68. (PMID: 20038793)
J Biol Chem. 2006 Nov 10;281(45):34457-64. (PMID: 16966319)
Bone Res. 2018 Apr 27;6:15. (PMID: 29736302)
Br J Nutr. 2011 Apr;105(8):1145-9. (PMID: 21129235)
Nutr J. 2007 Jan 16;6:2. (PMID: 17227589)
Am J Clin Nutr. 2006 Jun;83(6 Suppl):1505S-1519S. (PMID: 16841861)
Nutr Metab (Lond). 2005 Oct 10;2:26. (PMID: 16216119)
J Immunol. 2004 Feb 15;172(4):2504-10. (PMID: 14764723)
Clin Sci (Lond). 2012 Mar;122(5):203-14. (PMID: 22070434)
Cell. 2010 Sep 3;142(5):687-98. (PMID: 20813258)
Eur J Clin Nutr. 2004 Jun;58(6):839-45. (PMID: 15164103)
J Bone Miner Metab. 2007;25(6):337-44. (PMID: 17968485)
J Periodontol. 2010 Nov;81(11):1635-43. (PMID: 20572767)
Int J Obes (Lond). 2013 Aug;37(8):1079-87. (PMID: 23164698)
Life Sci. 2018 Apr 1;198:1-7. (PMID: 29432759)
Bone Res. 2013 Dec 31;1(4):336-45. (PMID: 26273511)
Pediatr Res. 2002 Mar;51(3):282-9. (PMID: 11861931)
Front Pharmacol. 2019 May 31;10:533. (PMID: 31214021)
Nat Rev Drug Discov. 2012 Aug;11(8):603-19. (PMID: 22790105)
Prog Lipid Res. 2015 Apr;58:121-45. (PMID: 25835096)
Exp Biol Med (Maywood). 2017 Dec;242(18):1765-1771. (PMID: 28893084)
Med Sci Monit. 2008 Mar;14(3):RA37-44. (PMID: 18301367)
Nutr Res Pract. 2014 Aug;8(4):360-7. (PMID: 25110554)
J Periodontal Res. 2017 Aug;52(4):695-703. (PMID: 28177133)
Biochem Biophys Res Commun. 2013 Jan 11;430(2):793-7. (PMID: 23206696)
J Healthc Eng. 2017;2017:3571267. (PMID: 29065587)
J Bone Miner Res. 2013 Mar;28(3):639-48. (PMID: 23044841)
Leuk Res. 2014 Oct;38(10):1260-5. (PMID: 25192858)
Radiol Med. 1994 Jun;87(6):741-6. (PMID: 8041925)
Front Endocrinol (Lausanne). 2014 Dec 09;5:208. (PMID: 25538684)
PLoS One. 2018 Jan 5;13(1):e0190539. (PMID: 29304057)
Stem Cells Int. 2016;2016:3753581. (PMID: 27298623)
J Bone Miner Res. 2003 Jul;18(7):1206-16. (PMID: 12854830)
JBMR Plus. 2019 Jan 15;3(3):e10126. (PMID: 30918918)
Calcif Tissue Int. 2019 May;104(5):544-553. (PMID: 30456556)
J Periodontal Res. 2012 Dec;47(6):740-9. (PMID: 22594616)

81825005 National Natural Science Foundation of China for Distinguished Young Scholars; 2018JY0568 Science & Technology Department of Sichuan Province; 81903033 National Natural Science Foundation of China

Keywords: bone diseases; bone homeostasis; bone metabolism; fatty acids

0 (Fatty Acids)

Date Created: 20191205 Date Completed: 20200305 Latest Revision: 20210110

20240104

PMC7046483

10.1111/cpr.12735

31797479