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Modelling exposure heterogeneity and density dependence in onchocerciasis using a novel individual-based transmission model, EPIONCHO-IBM: Implications for elimination and data needs.
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- Author(s): Hamley JID;Hamley JID;Hamley JID; Milton P; Milton P; Milton P; Walker M; Walker M; Walker M; Basáñez MG; Basáñez MG; Basáñez MG
- Source:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2019 Dec 05; Vol. 13 (12), pp. e0007557. Date of Electronic Publication: 2019 Dec 05 (Print Publication: 2019).- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE
- Publication Information: Original Publication: San Francisco, CA : Public Library of Science
- Subject Terms: Disease Transmission, Infectious* ; Environmental Exposure* ; Models, Statistical*; Onchocerciasis/*epidemiology ; Onchocerciasis/*transmission ; Simuliidae/*growth & development; Animals ; Burkina Faso/epidemiology ; Cameroon/epidemiology ; Cote d'Ivoire/epidemiology ; Female ; Humans ; Male ; Prevalence
- Abstract: Background: Density dependence in helminth establishment and heterogeneity in exposure to infection are known to drive resilience to interventions based on mass drug administration (MDA). However, the interaction between these processes is poorly understood. We developed a novel individual-based model for onchocerciasis transmission, EPIONCHO-IBM, which accounts for both processes. We fit the model to pre-intervention epidemiological data and explore parasite dynamics during MDA with ivermectin.
Methodology/principal Findings: Density dependence and heterogeneity in exposure to blackfly (vector) bites were estimated by fitting the model to matched pre-intervention microfilarial prevalence, microfilarial intensity and vector biting rate data from savannah areas of Cameroon and Côte d'Ivoire/Burkina Faso using Latin hypercube sampling. Transmission dynamics during 25 years of annual and biannual ivermectin MDA were investigated. Density dependence in parasite establishment within humans was estimated for different levels of (fixed) exposure heterogeneity to understand how parametric uncertainty may influence treatment dynamics. Stronger overdispersion in exposure to blackfly bites results in the estimation of stronger density-dependent parasite establishment within humans, consequently increasing resilience to MDA. For all levels of exposure heterogeneity tested, the model predicts a departure from the functional forms for density dependence assumed in the deterministic version of the model.
Conclusions/significance: This is the first, stochastic model of onchocerciasis, that accounts for and estimates density-dependent parasite establishment in humans alongside exposure heterogeneity. Capturing the interaction between these processes is fundamental to our understanding of resilience to MDA interventions. Given that uncertainty in these processes results in very different treatment dynamics, collecting data on exposure heterogeneity would be essential for improving model predictions during MDA. We discuss possible ways in which such data may be collected as well as the importance of better understanding the effects of immunological responses on establishing parasites prior to and during ivermectin treatment.
Competing Interests: The authors have no competing interests. - References: Bull World Health Organ. 1986;64(5):667-81. (PMID: 3492300)
J Med Entomol. 1997 Jan;34(1):64-7. (PMID: 9086713)
Parasit Vectors. 2016 Jun 13;9(1):338. (PMID: 27296630)
Parasitology. 1991 Dec;103 Pt 3:363-70. (PMID: 1780173)
Adv Parasitol. 2009;68:263-313. (PMID: 19289198)
Trends Parasitol. 2005 Feb;21(2):88-96. (PMID: 15664532)
Infect Immun. 2002 Jun;70(6):2796-804. (PMID: 12010965)
Trans R Soc Trop Med Hyg. 2007 Mar;101(3):256-69. (PMID: 17112556)
PLoS Negl Trop Dis. 2017 Jul 26;11(7):e0005816. (PMID: 28746337)
Int J Parasitol. 2010 May;40(6):641-50. (PMID: 19941867)
Adv Parasitol. 2016;94:247-341. (PMID: 27756456)
Lancet. 2018 Oct 6;392(10154):1207-1216. (PMID: 29361335)
Epidemics. 2017 Mar;18:4-15. (PMID: 28279455)
Parasit Vectors. 2015 Oct 22;8:547. (PMID: 26489753)
Tropenmed Parasitol. 1975 Jun;26(2):143-54. (PMID: 1172308)
PLoS One. 2014 Dec 29;9(12):e115886. (PMID: 25545677)
Tropenmed Parasitol. 1978 Sep;29(3):346-54. (PMID: 214908)
Parasit Vectors. 2016 Nov 14;9(1):581. (PMID: 27842567)
Parasitol Today. 1986 Oct;2(10):284-6. (PMID: 15462735)
Parasitology. 1995 May;110 ( Pt 4):409-27. (PMID: 7753582)
Parasitology. 2011 Mar;138(3):322-32. (PMID: 20946694)
Am J Trop Med Hyg. 2002 Dec;67(6):669-79. (PMID: 12518860)
Parasit Vectors. 2018 Jan 4;11(1):7. (PMID: 29301571)
Clin Infect Dis. 2018 Jun 1;66(suppl_4):S267-S274. (PMID: 29860291)
Parasit Vectors. 2016 Aug 05;9(1):432. (PMID: 27494934)
Comput Methods Programs Biomed. 1990 Jan;31(1):43-56. (PMID: 2311368)
Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):272-286. (PMID: 27693536)
Am J Trop Med Hyg. 2015 Jun;92(6):1245-52. (PMID: 25870427)
Am J Trop Med Hyg. 2013 Aug;89(2):293-300. (PMID: 23690555)
Parasitology. 2006 Jun;132(Pt 6):843-54. (PMID: 16469200)
Infect Dis Poverty. 2018 Mar 28;7(1):21. (PMID: 29587844)
Trans R Soc Trop Med Hyg. 2005 Mar;99(3):178-95. (PMID: 15653120)
Parasit Vectors. 2015 Oct 22;8:552. (PMID: 26489937)
Am J Trop Med Hyg. 2011 Dec;85(6):1041-9. (PMID: 22144441)
Infect Immun. 2000 Apr;68(4):1905-11. (PMID: 10722581)
J Anim Ecol. 2014 Nov;83(6):1379-86. (PMID: 24702134)
Ann Trop Med Parasitol. 1990 Dec;84(6):599-605. (PMID: 2076038)
Adv Parasitol. 1985;24:1-101. (PMID: 3904343)
Int J Parasitol. 2004 Mar 29;34(4):463-73. (PMID: 15013736)
Parasit Vectors. 2018 May 29;11(1):316. (PMID: 29843770)
Parasitology. 1996 Oct;113 ( Pt 4):331-55. (PMID: 8873475)
Int J Parasitol. 2004 Aug;34(9):1069-74. (PMID: 15313133)
J R Soc Interface. 2013 Jul 17;10(86):20121018. (PMID: 23864497)
J Infect Dis. 1995 Jul;172(1):204-10. (PMID: 7797912)
Lancet Infect Dis. 2008 May;8(5):310-22. (PMID: 18471776)
PLoS Negl Trop Dis. 2016 Jan 15;10(1):e0004328. (PMID: 26771545)
Epidemics. 2018 Dec;25:80-88. (PMID: 29884470)
Ann Trop Med Parasitol. 1987 Jun;81(3):215-28. (PMID: 3662664)
PLoS Negl Trop Dis. 2016 Feb 29;10(2):e0004392. (PMID: 26926855)
Proc Biol Sci. 2018 Jan 31;285(1871):. (PMID: 29386362)
Clin Exp Immunol. 1994 May;96(2):238-44. (PMID: 8187332)
J Infect Dis. 1991 Sep;164(3):581-7. (PMID: 1822959)
BMC Med. 2007 May 23;5:9. (PMID: 17521449)
PLoS Negl Trop Dis. 2008 Apr 30;2(4):e217. (PMID: 18446236)
Bull World Health Organ. 1968;39(2):137-46. (PMID: 4881066)
J Anim Ecol. 2006 Nov;75(6):1313-20. (PMID: 17032363)
Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15265-70. (PMID: 16217028)
Elife. 2018 Jan 23;7:. (PMID: 29357976)
PLoS Negl Trop Dis. 2016 Mar 04;10(3):e0004425. (PMID: 26942912)
Epidemics. 2017 Mar;18:56-66. (PMID: 28279457)
Acta Trop. 1987 Dec;44(4):445-57. (PMID: 2894134)
Bull World Health Organ. 2002;80(5):384-91. (PMID: 12077614)
Parasitol Today. 1988 Apr;4(4):91-7. (PMID: 15463054)
Parasit Vectors. 2016 Jan 27;9:40. (PMID: 26813296)
Parasitology. 2005 Jul;131(Pt 1):121-32. (PMID: 16038403)
Trans R Soc Trop Med Hyg. 1986;80(1):69-77. (PMID: 3727001)
Parasit Vectors. 2010 Jun 18;3:53. (PMID: 20565835)
Acta Trop. 1991 Feb;48(4):271-84. (PMID: 1674401)
Clin Infect Dis. 2015 Apr 15;60(8):1199-207. (PMID: 25537873)
Ann Trop Med Parasitol. 1987 Jun;81(3):253-62. (PMID: 3662667)
N Engl J Med. 2017 Nov 23;377(21):2044-2052. (PMID: 29116890)
Philos Trans R Soc Lond B Biol Sci. 1999 Apr 29;354(1384):809-26. (PMID: 10365406)
J Parasitol Res. 2013;2013:420928. (PMID: 23691275)
Lancet. 1997 Jul 5;350(9070):18-22. (PMID: 9217715)
Int J Parasitol. 2006 Nov;36(13):1367-72. (PMID: 16979644) - Grant Information: MR/R015600/1 United Kingdom MRC_ Medical Research Council
- Publication Date: Date Created: 20191206 Date Completed: 20200225 Latest Revision: 20210110
- Publication Date: 20240104
- Accession Number: PMC7006940
- Accession Number: 10.1371/journal.pntd.0007557
- Accession Number: 31805049
- Source:
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