Anti-apoptotic proteins in the autophagic world: an update on functions of XIAP, Survivin, and BRUCE.

Publisher: BioMed Central Country of Publication: England NLM ID: 9421567 Publication Model: Electronic Cited Medium: Internet ISSN: 1423-0127 (Electronic) Linking ISSN: 10217770 NLM ISO Abbreviation: J Biomed Sci Subsets: MEDLINE

Publication: 2009- : London : BioMed Central
Original Publication: Basel ; New York : S. Karger Medical and Scientific Publishers, c1994-

Apoptosis/*genetics ; Inhibitor of Apoptosis Proteins/*physiology ; Survivin/*physiology ; X-Linked Inhibitor of Apoptosis Protein/*physiology; Autophagy ; Humans ; Inhibitor of Apoptosis Proteins/genetics ; Survivin/genetics ; Tumor Cells, Cultured ; X-Linked Inhibitor of Apoptosis Protein/genetics

X-linked inhibitor of apoptosis protein (XIAP), survivin, and BRUCE are members of the inhibitor-of-apoptosis protein (IAP) family known for their inhibitory effects on caspase activity and dysregulation of these molecules has widely been shown to cause embryonic defects and to promote tumorigenesis in human. Besides the anti-apoptotic functions, recent discoveries have revealed that XIAP, survivin, and BRUCE also exhibit regulatory functions for autophagy in cells. As the role of autophagy in human diseases has already been discussed extensively in different reviews; in this review, we will discuss the emerging autophagic role of XIAP, survivin, and BRUCE in cancer cells. We also provide an update on the anti-apoptotic functions and the roles in maintaining DNA integrity of these molecules. Second mitochondria-derived activator of caspases (Smac) is a pro-apoptotic protein and IAPs are the molecular targets of various Smac mimetics currently under clinical trials. Better understanding on the functions of XIAP, survivin, and BRUCE can enable us to predict possible side effects of these drugs and to design a more "patient-specific" clinical trial for Smac mimetics in the future.

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MOST 108-2320-B-006-024 Ministry of Science and Technology, Taiwan

Keywords: Apoptosis; Autophagy; BRUCE; IAP; Smac; Survivin; XIAP

0 (BIRC5 protein, human)
0 (BIRC6 protein, human)
0 (Inhibitor of Apoptosis Proteins)
0 (Survivin)
0 (X-Linked Inhibitor of Apoptosis Protein)
0 (XIAP protein, human)

Date Created: 20200206 Date Completed: 20200715 Latest Revision: 20200715

20240105

PMC7001279

10.1186/s12929-020-0627-5

32019552