Genome wide analysis of gene expression changes in skin from patients with type 2 diabetes.

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  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
      Gene Expression* ; Genome, Human*; Diabetes Mellitus, Type 2/*genetics ; Skin/*pathology; Adult ; Aged ; Aged, 80 and over ; Calcium Signaling/genetics ; Diabetes Mellitus, Type 2/pathology ; Female ; Gene Expression Regulation ; Humans ; Inflammation/genetics ; Male ; Middle Aged ; Pseudogenes/genetics ; RNA, Long Noncoding/genetics ; Sequence Analysis, RNA ; Ulcer ; Wound Healing ; Young Adult
    • Abstract:
      Non-healing chronic ulcers are a serious complication of diabetes and are a major healthcare problem. While a host of treatments have been explored to heal or prevent these ulcers from forming, these treatments have not been found to be consistently effective in clinical trials. An understanding of the changes in gene expression in the skin of diabetic patients may provide insight into the processes and mechanisms that precede the formation of non-healing ulcers. In this study, we investigated genome wide changes in gene expression in skin between patients with type 2 diabetes and non-diabetic patients using next generation sequencing. We compared the gene expression in skin samples taken from 27 patients (13 with type 2 diabetes and 14 non-diabetic). This information may be useful in identifying the causal factors and potential therapeutic targets for the prevention and treatment of diabetic related diseases.
      Competing Interests: The authors have declared that no competing interests exist.
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    • Grant Information:
      R01 HL141761 United States HL NHLBI NIH HHS; R21 EB023551 United States EB NIBIB NIH HHS; R21 EB024147 United States EB NIBIB NIH HHS
    • Accession Number:
      0 (RNA, Long Noncoding)
    • Publication Date:
      Date Created: 20200222 Date Completed: 20200505 Latest Revision: 20210206
    • Publication Date:
      20240105
    • Accession Number:
      PMC7034863
    • Accession Number:
      10.1371/journal.pone.0225267
    • Accession Number:
      32084158