Associations Between the Triglyceride to High-Density Lipoprotein Cholesterol Ratio and Metabolic Syndrome, Insulin Resistance, and Lifestyle Habits in Healthy Japanese.

Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101150318 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8518 (Electronic) Linking ISSN: 15404196 NLM ISO Abbreviation: Metab Syndr Relat Disord Subsets: MEDLINE

Original Publication: Larchmont, NY : Mary Ann Liebert, Inc., c2003-

Habits* ; Healthy Lifestyle* ; Insulin Resistance*; Cholesterol, HDL/*blood ; Metabolic Syndrome/*blood ; Triglycerides/*blood; Adult ; Aged ; Biomarkers/blood ; Cross-Sectional Studies ; Exercise ; Female ; Health Surveys ; Humans ; Japan/epidemiology ; Male ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/epidemiology ; Middle Aged ; Risk Assessment ; Risk Factors ; Sedentary Behavior ; Smoking/adverse effects ; Smoking/epidemiology

Background: The triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio is related to insulin resistance (IR). However, little information is available on whether TG/HDL-C is associated with IR and components of metabolic syndrome (MetS) and how lifestyle habits affect TG/HDL-C in the healthy Japanese population. Methods: In total, 1068 Japanese subjects who had undergone an annual health examination and who were not receiving medication were recruited. Determinants for TG/HDL-C ratio were investigated using multiple regression analyses. The subjects were divided into three groups by lifestyle habits ( i.e. , smoking, exercise, and physical activity), homeostasis model assessment of IR (HOMA-IR), and fasting plasma glucose, four groups by alcohol intake, and five groups by numbers of MetS components to compare TG/HDL-C values. All analyses were done separately by sex. Results: Multiple regression analyses revealed that waist circumference and smoking were positively associated with TG/HDL-C in both men and women, whereas physical activity was negatively associated with TG/HDL-C ratio in women. TG/HDL-C increased with increasing number of MetS in both men and women. TG/HDL-C increased as HOMA-IR increased in both men and women, when subjects were stratified according to HOMA-IR. TG/HDL-C values were lower in both men and women who exercised regularly, had high physical activity, or were nonsmokers. Independent of exercise and physical activity, TG/HDL-C was higher in smokers than in nonsmokers for both men and women. The relationship between TG/HDL-C and alcohol intake was not statistically significant in both men and women. Conclusions: The TG/HDL-C ratio is associated with IR, components of MetS, exercise, physical activity, and smoking, but not alcohol intake, in healthy Japanese subjects.

Keywords: annual health examination; insulin resistance; lifestyle habit; metabolic syndrome; triglyceride to high-density lipoprotein cholesterol ratio

0 (Biomarkers)
0 (Cholesterol, HDL)
0 (Triglycerides)

Date Created: 20200320 Date Completed: 20210824 Latest Revision: 20210824

20240105

10.1089/met.2019.0123

32191558