Practical example of multiple antibody screening for evaluation of malaria control strategies.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, [2002-
    • Subject Terms:
      Antibodies, Protozoan/*blood ; Antigens, Protozoan/*immunology ; Malaria, Falciparum/*diagnosis ; Malaria, Falciparum/*prevention & control; Adolescent ; Adult ; Aged ; Antibodies, Protozoan/immunology ; Antigens, Protozoan/classification ; Asymptomatic Infections/epidemiology ; Biomarkers/blood ; Child ; Child, Preschool ; Cote d'Ivoire/epidemiology ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Infant ; Longitudinal Studies ; Malaria, Falciparum/epidemiology ; Mass Screening/statistics & numerical data ; Middle Aged ; Retrospective Studies ; Seroepidemiologic Studies ; Young Adult
    • Abstract:
      Background: Ongoing efforts to fight Plasmodium falciparum malaria has reduced malaria in many areas, but new tools are needed to monitor further progress, including indicators of decreasing exposure to parasite infection. Sero-surveillance is considered promising to monitor exposure, transmission and immunity.
      Methods: IgG responses to three antigen biomarkers were evaluated in a retrospective study involving: (i) surveys of 798 asymptomatic villagers from 2 Senegalese endemic settings conducted before 2002 and after the 2013 intensification of control measures, and (ii) in 105 symptomatic individuals from different settings in Côte d'Ivoire. Response to up to eight P. falciparum antigens, including recombinant MSP1p9 antigen and LSA1 41 peptide, were analysed using multiplex technology and responses to whole P. falciparum schizont extract (SE, local strain adapted to culture) were measured by ELISA.
      Results: MSP1p9 and LSA1 41 IgG responses were shown to be relevant indicators monitoring immune status in the different study sites both from Côte d'Ivoire and Senegal. Between 2002 and 2013, individuals participating in both studies showed higher decline of sero-positivity in young (< 15 years: range 12% to 50%) than older (> 15 years: no decline to 15%) individuals from Dielmo and Ndiop. A mathematical sero-catalytic model from the complete Dielmo/Ndiop survey was used to reconstruct declining levels of sero-positivity in more detail, demonstrating that anti-SE seroprevalence levels most accurately reflected malaria exposure in the two villages.
      Conclusion: For standard screening of population immune status at sites envisaging elimination, the use of ELISA-based assays targeting selected antigens can contribute to provide important epidemiologic surveillance data to aid malaria control programmes.
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    • Contributed Indexing:
      Keywords: Asymptomatic carriage; Biomarkers; ELISA; IgG; Ivory Coast; MAGPIX; Malaria; Multiple antigens; Multiplex; Plasmodium falciparum; Symptomatic malaria
    • Accession Number:
      0 (Antibodies, Protozoan)
      0 (Antigens, Protozoan)
      0 (Biomarkers)
      0 (Immunoglobulin G)
    • Publication Date:
      Date Created: 20200321 Date Completed: 20201105 Latest Revision: 20201105
    • Publication Date:
      20240105
    • Accession Number:
      PMC7082935
    • Accession Number:
      10.1186/s12936-020-03186-9
    • Accession Number:
      32192514