MicroRNAs As Master Regulators of Atherosclerosis: From Pathogenesis to Novel Therapeutic Options.

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  • Additional Information
    • Source:
      Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 100888899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7716 (Electronic) Linking ISSN: 15230864 NLM ISO Abbreviation: Antioxid Redox Signal Subsets: MEDLINE
    • Publication Information:
      Original Publication: Larchmont, NY : Mary Ann Liebert, Inc., 1999-
    • Subject Terms:
      Biomarkers* ; Gene Expression Regulation*; Atherosclerosis/*etiology ; MicroRNAs/*genetics; Animals ; Atherosclerosis/diagnosis ; Atherosclerosis/therapy ; Disease Management ; Disease Susceptibility ; Genetic Therapy ; Humans ; Liquid Biopsy/methods ; Molecular Diagnostic Techniques ; Risk Factors
    • Abstract:
      Significance: Cardiovascular disease (CVD) remains the major cause of morbidity and mortality worldwide. Accumulating evidence indicates that atherosclerosis and its sequelae, coronary artery disease, contribute to the majority of cardiovascular deaths. Atherosclerosis is a chronic inflammatory disease of the arteries in which atherosclerotic plaques form within the vessel wall. Epidemiological studies have identified various risk factors for atherosclerosis, such as diabetes, hyperlipidemia, smoking, genetic predisposition, and sedentary lifestyle. Recent Advances: Through the advancement of genetic manipulation techniques and their use in cardiovascular biology, it was shown that small RNAs, especially microRNAs (miRNAs), are dynamic regulators of disease pathogenesis. They are considered to be central during the regulation of gene expression through numerous mechanisms and provide a means to develop biomarkers and therapeutic tools for the diagnosis and therapy of atherosclerosis. Circulating miRNAs encapsulated within membrane-surrounded vesicles, which originate from diverse subcellular compartments, are now emerging as novel regulators of intercellular communication. The miRNAs, in both freely circulating and vesicle-bound forms, represent a valuable tool for diagnosing and monitoring CVD, recently termed as "liquid biopsy." Critical Issues: However, despite the recent advancements in miRNA-based diagnostics and therapeutics, understanding how miRNAs can regulate atherosclerosis is still crucial to achieving an effective intervention and reducing the disease burden. Future Directions: We provide a landscape of the current developmental progression of RNA therapeutics as a holistic approach for treating CVD in different animal models and clinical trials. Future interrogations are warranted for the development of miRNA-based therapeutics to overcome challenges for the treatment of the disease.
    • Contributed Indexing:
      Keywords: biomarker; cardiovascular disease; exosomes; microRNAs; microvesicles; therapeutics
    • Accession Number:
      0 (Biomarkers)
      0 (MicroRNAs)
    • Publication Date:
      Date Created: 20200516 Date Completed: 20210819 Latest Revision: 20210819
    • Publication Date:
      20240105
    • Accession Number:
      10.1089/ars.2020.8107
    • Accession Number:
      32408755