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Protecting HaCaT cells from ionizing radiation using persimmon tannin- Aloe gel composite.
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- Author(s): Qian X;Qian X; Wang Z; Wang Z; Ning J; Ning J; Qin C; Qin C; Gao L; Gao L; He N; He N; Lin D; Lin D; Zhou Z; Zhou Z; Li G; Li G
- Source:
Pharmaceutical biology [Pharm Biol] 2020 Dec; Vol. 58 (1), pp. 510-517.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9812552 Publication Model: Print Cited Medium: Internet ISSN: 1744-5116 (Electronic) Linking ISSN: 13880209 NLM ISO Abbreviation: Pharm Biol Subsets: MEDLINE
- Publication Information: Publication: [London] : Taylor & Francis
Original Publication: Lisse, the Netherlands : Swets & Zeitlinger, c1998- - Subject Terms: Aloe* ; Diospyros* ; Radiation, Ionizing*; Cytoprotection/*drug effects ; Plant Extracts/*pharmacology ; Tannins/*pharmacology; Cell Survival/drug effects ; Cell Survival/physiology ; Cell Survival/radiation effects ; Cytoprotection/physiology ; Cytoprotection/radiation effects ; Dose-Response Relationship, Drug ; Gels ; HaCaT Cells ; Humans ; Plant Extracts/isolation & purification ; Tannins/isolation & purification
- Abstract: Context: Persimmon tannin (extract of Diospyros kaki L.f [Ebenaceae]) and Aloe gel ( extract of Aloe vera (L.) Burm.f. [Asphodelaceae]) are known as anti-radiation agents. However, radiation resistance of the persimmon tannin- Aloe gel composite remains inconclusive. Objective: To investigate the capacity of the persimmon tannin- Aloe gel composite to protect against ionising radiation at the cellular level. Materials and methods: HaCaT (human epidermal keratinocytes) cells were pre-treated with PT-A-1 (the mass ratio of persimmon tannin and Aloe gel was 2:1) or the single component (persimmon tannin or Aloe gel) at various concentrations (0, 50, 100, 200, 400, 800 μg/mL. Control group: medium with no HaCaT cells), and then radiated with X-rays (radiation dose: 4, 8, 12, 16, and 20 Gy). Cell viability, cell apoptosis, and radiation-induced intracellular reactive oxygen species (ROS) generation were analysed by CCK-8, Hoechst 33258 staining/flow cytometry, and 2',7'-dichlorfluorescein diacetate (DCFH-DA) assay, respectively, for 12 or 24 h incubation after radiation. Results: The optimal radiation dose and post-radiation incubation period were determined to be 8 Gy and 12 h. CCK-8 activity detection showed that the cell activity was 77.85% ( p < 0.05, IC
50 = 55.67 μg/mL). The apoptotic rate was the lowest (4.32%) at 200 μg/mL of PT-A-1 towards HaCaT cells. ROS production was the most effectively suppressed by 200 μg/mL PT-A-1 towards HaCaT cells. Discussion and conclusions: The persimmon tannin- Aloe gel composite has good radioprotective effect, and which will facilitate its clinic application as a potential natural anti-radiation agent in future. - References: Biomed Pharmacother. 2019 Mar;111:151-161. (PMID: 30579254)
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Acta Crystallogr D Biol Crystallogr. 2000 Mar;56(Pt 3):328-41. (PMID: 10713520) - Contributed Indexing: Keywords: Human epidermal keratinocytes cells; Radiation resistance; X-rays
- Accession Number: 0 (Gels)
0 (Plant Extracts)
0 (Tannins) - Publication Date: Date Created: 20200602 Date Completed: 20210326 Latest Revision: 20211205
- Publication Date: 20240104
- Accession Number: PMC8641672
- Accession Number: 10.1080/13880209.2020.1767158
- Accession Number: 32476533
- Source:
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