Pulmonary microvascular metastases in cervical carcinoma: A case series.

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  • Additional Information
    • Source:
      Publisher: Medknow Publications Country of Publication: India NLM ID: 2985196R Publication Model: Print Cited Medium: Internet ISSN: 0972-2823 (Electronic) Linking ISSN: 00223859 NLM ISO Abbreviation: J Postgrad Med Subsets: MEDLINE
    • Publication Information:
      Publication: Mumbai : Medknow Publications
      Original Publication: Bombay, India.
    • Subject Terms:
      Adenocarcinoma/*secondary ; Lung/*blood supply ; Lung Neoplasms/*secondary ; Neoplastic Cells, Circulating/*pathology ; Thrombotic Microangiopathies/*pathology ; Uterine Cervical Neoplasms/*pathology; Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Aged ; Autopsy ; Biomarkers, Tumor/metabolism ; Female ; Humans ; Lung/pathology ; Lung Neoplasms/blood supply ; Lung Neoplasms/pathology ; Middle Aged ; Neoplasm Metastasis ; Pulmonary Artery/pathology ; Thrombotic Microangiopathies/mortality ; Uterine Cervical Neoplasms/mortality
    • Abstract:
      Pulmonary microvascular tumor embolism (PMTE), pulmonary tumor thrombotic microangiopathy (PTTM), and lymphangitis carcinomatosis (LC) have an intricate pathophysiology and usually occur with cancers of breast, stomach, and lung. Microvascular pulmonary metastases attributable to cervical cancer are a rarity. Clinical presentation and autopsy findings of patients with microvascular pulmonary metastases in cervical cancers were studied with a review of literature. Four patients (mean age of 55.5 years) with carcinoma cervix showed microvascular metastases. Three of whom presented with respiratory symptoms, and the fourth case was unresponsive on presentation. Each patient succumbed to their illness shortly after admission. Autopsy examination performed on each patient depicted varying combination of PMTE, PTTM, and LC, all with squamous histology. This case series highlights the rare association of carcinoma cervix with the aforementioned microvascular phenomena. Besides, it underscores the sequential mechanism of occurrence of microvascular pulmonary metastasis and the associated guarded prognosis.
      Competing Interests: None
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    • Contributed Indexing:
      Keywords: cervical carcinoma; lymphangitis carcinomatosis; pulmonary microvascular tumor embolism; pulmonary tumor thrombotic microangiopathy
    • Accession Number:
      0 (Biomarkers, Tumor)
    • Publication Date:
      Date Created: 20200718 Date Completed: 20201116 Latest Revision: 20201116
    • Publication Date:
      20240105
    • Accession Number:
      PMC7542055
    • Accession Number:
      10.4103/jpgm.JPGM_243_20
    • Accession Number:
      32675452